LncRNA LINC01772 promotes metastasis and EMT process in cervical cancer by sponging miR-3611 to relieve ZEB1

Ma, Tong; Wang, Fafen; Wang, Xiaohui

doi:10.32604/biocell.2019.06989

Cited by 6 publications

(3 citation statements)

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“…Epithelial-mesenchymal transition (EMT) has been recognized as a vital process in the development of multiple tumors, including COAD. [28][29][30] Therefore, we examined the expression of epithelial marker E-cadherin, mesenchymal markers N-cadherin and vimentin, and EMT-inducing transcription factor snail. We observed that OSR1 overexpression markedly increased E-cadherin expression and reduced N-cadherin, vimentin, and snail expression, while OSR1 knockdown yielded opposite results.…”

Section: Discussionmentioning

confidence: 99%

<p>Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling</p>

Zhang¹,

Jiang²

2020

OTT

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Introduction: Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods: OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockdown were analyzed by in vitro CCK-8, transwell and flow cytometry assays, and by in vivo xenograft model. Results: OSR1 expression was downregulated in COAD and low expression level of OSR1 was positively correlated with tumor stage and lymph node metastasis. Furthermore, low OSR1 expression was significantly associated with poor overall survival (OS) and distant metastasis-free survival (DMFS). Lentivirus-mediated restoration of OSR1 expressioninhibited proliferation, invasion and migration while induced cell cycle arrest and apoptosis in COAD cells in vitro, and inhibited tumor growth in vivo. In contrast, OSR1 knockdown promoted proliferation, invasion and migration in COAD cells in vitro. Mechanistically, OSR1 exerted anticancer effects by inhibiting FAK-mediated activation of Akt and MAPK pathways. Conclusion: Our findings suggest that OSR1 functions as a tumor suppressor in COAD by suppressing FAK-mediated activation of Akt and MAPK pathways.

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Section: Discussionmentioning

confidence: 99%

<p>Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling</p>

Zhang¹,

Jiang²

2020

OTT

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“…Researches have revealed that circRNAs can regulate various cell biology through interacting with couples of microRNAs (miRNAs), that has been named as a competing endogenous RNA (ceRNA) mechanism [ 6 – 9 , 16 , 17 ]. miRNAs may regulate various functions through binding with the 3′ untranslated regions (UTR) of downstream target genes in HCC [ 18 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Elevated Circ_0067835 Could Accelerate Cell Proliferation and Metastasis via miR-1236-3p/Twist2 Axis in Hepatocellular Carcinoma

Chen

2022

BioMed Research International

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Hepatocellular carcinoma (HCC) is a malignant cancer with leading mortality worldwide. Circ_0067835 is a circRNA which plays an important role in various kinds of tumor, while the potential functions of circ_0067835 in HCC remains unclear. In this study, our results of microarray and real-time PCR (RT-PCR) showed that it was obviously elevated in human HCC tumor tissues and HCC cell lines. Inhibition of circ_0067835 restrained cell proliferation and migration in vitro. Furthermore, miR-1236-3p was decreased in tumor samples, and it was indicated to be a target of circ_0067835. Moreover, Twist2 was established to be elevated in HCC tissues, and we identified it as the direct target of miR-1236-3p. Finally, we found that knockdown of miR-1236-3p could reverse the circ_0067835 inhibition effects in HCC cells. In conclusion, our study demonstrated that circ_0067835 contributed to promoting hepatocellular carcinoma cell proliferation and metastasis through downregulating miR-1236-3p expression and then elevating Twist2 expression, which might provide a new vision for HCC patients.

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“…LncRNAs refer to long nonprotein-coded transcripts with lengths of >200 bp. Increasing evidence suggests that LncRNAs are associated with the development and progression of a variety of cancers [21]. LncRNAs have been reported to be involved in the development of PDAC [22].…”

Section: Introductionmentioning

confidence: 99%

Emerging Role of Exosomal-Derived Long Noncoding RNAs in Human PDAC

Di¹,

Tian²,

Yang³

2021

Visc Med

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Background: The incidence and mortality of pancreatic ductal adenocarcinoma (PDAC) are increasing recently. Most patients with PDAC are diagnosed at advanced stage because of the high invasiveness of cancer cells and the lack of typical early symptoms. Therefore, early diagnosis of PDAC is very important to improve the prognosis. Exosomes play crucial role in intercellular communication and deliver the contents to recipient cells to regulate their biological behaviors. Recent evidence suggests emerging role of exosomes in the carcinogenesis of a variety of cancers including PDAC. Long noncoding RNAs (LncRNAs) have been reported to be involved in the development of PDAC. It has been proved that LncRNAs have the potential to be biomarkers and therapeutic targets for PDAC. Moreover, increasing number of studies focus on the role of exosomal LncRNAs in PDAC. Summary: In this review, we summarize the current status on our understanding of the role of exosomal-derived LncRNAs in the progression and metastasis of PDAC. Key Messages: We focus on challenges in the potential of exosomal-derived LncRNAs as novel diagnostic and prognostic markers and therapeutic targets of PDAC. In addition, we provide an overview about the demonstrated important role of exosomal LncRNAs in the progression of PDAC.

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LncRNA LINC01772 promotes metastasis and EMT process in cervical cancer by sponging miR-3611 to relieve ZEB1

Cited by 6 publications

References 0 publications

<p>Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling</p>

<p>Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling</p>

The Elevated Circ_0067835 Could Accelerate Cell Proliferation and Metastasis via miR-1236-3p/Twist2 Axis in Hepatocellular Carcinoma

Emerging Role of Exosomal-Derived Long Noncoding RNAs in Human PDAC

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