&lt;p&gt;Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling&lt;/p&gt;

Zhang, Fang; Jiang, Zheng

doi:10.2147/ott.s242386

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…Odd-skipped related 1 (OSR1) is an odd-skipped family zincfinger protein (So and Danielian, 1999). OSR1 plays a vital role in heart and urogenital development, such as of kidneys and colon (Wang et al, 2005;Zhang and Jiang, 2020). In our study, it was found to play an important role in VV, suggesting that it can be a novel target for further studies.…”

Section: Discussionmentioning

confidence: 76%

Comprehensive bioinformatics analysis reveals biomarkers of DNA methylation-related genes in varicose veins

Liu²,

Liu³

et al. 2022

Front. Genet.

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Background: Patients with Varicose veins (VV) show no obvious symptoms in the early stages, and it is a common and frequent clinical condition. DNA methylation plays a key role in VV by regulating gene expression. However, the molecular mechanism underlying methylation regulation in VV remains unclear.Methods: The mRNA and methylation data of VV and normal samples were obtained from the Gene Expression Omnibus (GEO) database. Methylation-Regulated Genes (MRGs) between VV and normal samples were crossed with VV-associated genes (VVGs) obtained by weighted gene co-expression network analysis (WGCNA) to obtain VV-associated MRGs (VV-MRGs). Their ability to predict disease was assessed using receiver operating characteristic (ROC) curves. Biomarkers were then screened using a random forest model (RF), support vector machine model (SVM), and generalized linear model (GLM). Next, gene set enrichment analysis (GSEA) was performed to explore the functions of biomarkers. Furthermore, we also predicted their drug targets, and constructed a competing endogenous RNAs (ceRNA) network and a drug target network. Finally, we verified their mRNA expression using quantitative real-time polymerase chain reaction (qRT-PCR).Results: Total three VV-MRGs, namely Wnt1-inducible signaling pathway protein 2 (WISP2), Cysteine-rich intestinal protein 1 (CRIP1), and Odd-skipped related 1 (OSR1) were identified by VVGs and MRGs overlapping. The area under the curves (AUCs) of the ROC curves for these three VV-MRGs were greater than 0.8. RF was confirmed as the optimal diagnostic model, and WISP2, CRIP1, and OSR1 were regarded as biomarkers. GSEA showed that WISP2, CRIP1, and OSR1 were associated with oxidative phosphorylation, extracellular matrix (ECM), and respiratory system functions. Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR-21-5p and that PAX2 might treat VV by targeting OSR1. Finally, qRT-PCR results showed that the mRNA expression of the three genes was consistent with the results of the datasets.Conclusion: This study identified WISP2, CRIP1, and OSR1 as biomarkers of VV through comprehensive bioinformatics analysis, and preliminary explored the DNA methylation-related molecular mechanism in VV, which might be important for VV diagnosis and exploration of potential molecular mechanisms.

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Section: Discussionmentioning

confidence: 76%

Comprehensive bioinformatics analysis reveals biomarkers of DNA methylation-related genes in varicose veins

Liu²,

Liu³

et al. 2022

Front. Genet.

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“…[20][21][22] For example, Zhang and Jiang showed that odd-skipped related transcription factor 1 (OSR1) affected HCC progression and induced apoptosis by inhibiting MAPK pathways. 23 They also mentioned that SN38 could induce the activation of the MAPK pathway and promote autophagy, thereby reducing the chemoresistance of tumor cells. 24 Hepatocellular carcinoma exhibited an elevated mutational burden compared to normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of cell death genes in hepatocellular carcinoma based on multi-omics data

et al. 2023

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Background. Hepatocellular carcinoma (HCC) is a common tumor of the digestive system. Cell death is an essential process in normal tissue that consists of 3 classical pathways: apoptosis, necrosis and autophagy.Objectives. To perform a comprehensive analysis of the impact of cell death on liver cancer. Materials and methods.The Kyoto Encyclopedia of Genes and Genomes (KEGG) database and the Cancer Genome Atlas (TCGA) datasets were used to analyze the relationships between mutations in cell death-related genes and clinical variables of HCC. Then, we applied the DESeq2 package to identify aberrantly expressed genes in HCC and their related biological functions through a Pearson correlation analysis. Finally, a cell death-related signature of HCC was constructed using the single-factor Cox regression.Results. We identified the genes involved in apoptosis, necrosis and autophagy, of which TP53 and SPTA1 had the highest frequency of mutations. The results revealed that cell death-related tumor mutational burden (TMB) was significant for the pathologic stage and had a strong relationship with the prognosis. Moreover, 53 cell death-related genes that are differentially expressed in HCC were screened, and 3 of them were correlated with HCC prognosis. Harvey rat sarcoma viral oncogene homolog (HRAS) affected the infiltration of immune cells and was closely correlated with ferroptosis. Peptidylprolyl isomerase A (PPIA) played a significant role in mitochondrial pathways. At last, we constructed a cell death-related signature of HCC using 10 prognosis-related genes and a nomogram based on 3 variables (expression, group and stage).Conclusions. This study provided a comprehensive analysis of cell death-related genes in HCC based on multi-omics data, identified the contribution of each variable to clinical outcome and predicted the survival probability of HCC patients more directly.

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“…Colon adenocarcinoma (COAD), as the most common type of colon cancer, ranks fourth most common cancer by incidence and the second leading cause of cancer-related deaths worldwide (18,19). Although the diagnosis and treatment of COAD patients are much improved, the survival rate of these patients remains unsatisfactory, mostly due to the latediagnosis (20,21). Increasing data has indicated the correlation of the immune cell infiltration in colon cancer with the patients' clinical outcomes (22).…”

Section: Introductionmentioning

confidence: 99%

ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19

Ahmadi

Pashangzadeh

Mousavi

et al. 2021

International Immunopharmacology

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<p>Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling</p>

Cited by 9 publications

References 31 publications

Comprehensive bioinformatics analysis reveals biomarkers of DNA methylation-related genes in varicose veins

Comprehensive bioinformatics analysis reveals biomarkers of DNA methylation-related genes in varicose veins

Comprehensive analysis of cell death genes in hepatocellular carcinoma based on multi-omics data

ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19

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