LncRNA MAFG-AS1-induced acute myeloid leukemia development via modulating miR-147b/HOXA9

Long non-coding RNAs: emerging functional players in the pathobiology and progression of myeloid leukemia

“…Overexpression of the protooncogene lncRNA Frontiers in RNA Research frontiersin.org MALAT1 was reported to contribute to cancer phenotypes and IM sensitivity of CML cells via miR-328 targeting (Wen et al, 2018). The lncRNA ADORA2A-AS1 was also found to be overexpressed in CML; using the loss of function study, this lncRNA was shown to exert tumor-promoting activities and reduce IM sensitivity via sponging miR-665 and thereby regulating TGFBR1 and ABCC2 (Liu Y. et al, 2022). The lncRNA PLIN2 was found to promote CML progression via regulation of the GSK3 and Wnt/β-catenin signaling pathways both in vitro and in vivo; high levels of PLIN2 were shown to be the result of regulation by CEBPA, which is also upregulated in CML (Sun et al, 2017).…”

“…CCAT1 represses monocytic differentiation and promotes cell growth via miR-155 while markedly increasing the viability and metastasis of AML cells via the CCAT1/miR-490-3p/ MAPK1/c-Myc positive feedback loop (Chen et al, 2016;Wang C. et al, 2020). Very recently, elevated levels of the lncRNA MAFG-AS1 were shown to induce cell growth and epithelial-mesenchymal transitions (EMTs) in AML cells via sponging miR-147b and promoting the expression of HOXA9 indirectly (Yao et al, 2022). Given its repressed expression in AML, the lncRNA TP73-AS1 was revealed to sponge miR-21 and hence upregulate its downstream target PTEN to affect cellular proliferation in AML (Yuan et al, 2021).…”

“…The lncRNA CCAT2 was found to be highly expressed in CML patients and was linked to IM resistance, suggesting that it is a reliable molecular marker for predicting IM responses in CML patients in the CP (Shehata et al, 2022). Liu J. et al (2022) have shown that the lncRNA HOTTIP, which is highly expressed in IM-resistant patients and cell lines, recruits EZH2 to suppress the expression of the PTEN gene contributing to IM resistance. A recent report highlighted that autophagy is associated with drug resistance in CML cells; the study revealed that the lncRNA OIP5-AS1 promotes autophagy-related IM resistance in CML by sponging miR-30e-5p and modulating ATG12 levels (Dai et al, 2021).…”