2021
DOI: 10.3892/mmr.2021.12142
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lncRNA NEAT1 regulates gastric carcinoma cell proliferation, invasion and apoptosis via the miR‑500a‑3p/XBP‑1 axis

Abstract: Gastric cancer is a serious malignant tumor. Despite progression in gastric cancer research in recent years, the specific molecular mechanism underlying the pathogenesis of the disease is not completely understood. Long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) affects the proliferation and metastasis of multiple types of tumor cells in colorectal cancer and breast cancer but its specific role in gastric cancer requires further investigation. The aim of the present study was to … Show more

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Cited by 18 publications
(10 citation statements)
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“…The inhibition of glycolysis by miR-500a-3p was only partially restored by CDK6 overexpression, indicating other targets might also be involved in miR-500a-3pmediated regulation of glycolysis. Some reported targets of miR-500a-3p, such as XBP1 and FBXW7, may regulate glycolysis directly or indirectly [11,[27][28][29]. Further studies may be needed to validate the mechanistic link of miR-500a-3p and these targets in modulating glycolysis in CRC.…”
Section: Discussionmentioning
confidence: 99%
“…The inhibition of glycolysis by miR-500a-3p was only partially restored by CDK6 overexpression, indicating other targets might also be involved in miR-500a-3pmediated regulation of glycolysis. Some reported targets of miR-500a-3p, such as XBP1 and FBXW7, may regulate glycolysis directly or indirectly [11,[27][28][29]. Further studies may be needed to validate the mechanistic link of miR-500a-3p and these targets in modulating glycolysis in CRC.…”
Section: Discussionmentioning
confidence: 99%
“…Others assessed the correlation between ER stress or cell death and the relative quantity of NEAT1 RNA in gastric cancer tissues. While NEAT1 expression was reduced, levels of ER stress and apoptosis marker proteins were elevated [ 55 ]. Taken together, the striking finding here and elsewhere is the described effects of NEAT1 silencing or TGFβ1, TNFα, TG, or TM stimulation on migration, proliferation, and cell size (and NEAT1 expression for the later), respectively, supporting the role of NEAT1 as relevant factor for various regulatory mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies suggested that NEAT1 promotes tumor development by downregulating target miRNAs. Zhou et al [ 54 ] reported that NEAT1 targets and downregulates miR-500a-3p, promoting gastric cancer cell proliferation and invasion; Huang et al [ 55 ] suggested that NEAT1 promotes pancreatic cancer progression by negatively regulating miR-506-3p; whereas Zhang et al [ 56 ] showed that upregulation of NEAT1 is involved in the proliferation of glioma cells by negatively regulating miR-324-5p. However, the role of NEAT1 in CAC has rarely been reported.…”
Section: Discussionmentioning
confidence: 99%