LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values

Li, Qingyong; Li, Panrong; Su, Jinling; Liu, Suping; Yang, Xiaoman; Yang, Yuejin; Niu, Suocheng

doi:10.3892/etm.2019.7671

Cited by 14 publications

(20 citation statements)

References 21 publications

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“…A study by Li et al in 2019 27 demonstrated that lncRNA NKILA was specifically upregulated in patients with T2DM who later developed diabetic-related complications such as cardiomyopathy, suggesting that overexpression of the lncRNA NKILA may contribute to cardiomyocyte apoptosis and its involvement in the progression of diabetic cardiomyopathy (DC). It was suggested that suppressing expression of the lncRNA NKILA may inhibit the development of DC.…”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that suppressing expression of the lncRNA NKILA may inhibit the development of DC. 27 …”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that suppressing expression of the lncRNA NKILA may inhibit the development of DC. 27 The apoptosis of cardiomyocytes under high-glucose conditions contributes to the pathogenesis of DC, 28 overexpression, as well as knockdown of the lncRNA NKILA accelerated and inhibited apoptotic cell death, respectively. 27 Compared with healthy subjects, patients with T2DM showed a more than fivefold increase in expression of the lncRNA NEAT1.…”

Section: Discussionmentioning

confidence: 99%

“…27 The apoptosis of cardiomyocytes under high-glucose conditions contributes to the pathogenesis of DC, 28 overexpression, as well as knockdown of the lncRNA NKILA accelerated and inhibited apoptotic cell death, respectively. 27 Compared with healthy subjects, patients with T2DM showed a more than fivefold increase in expression of the lncRNA NEAT1. Patients with T2DM with weight loss and fatigue showed higher lncRNA NEAT1 expression compared with their counterparts; patients with T2DM with wound healing showed higher expression of the lncRNA NEAT1 compared with those with slow wound healing.…”

Section: Discussionmentioning

confidence: 99%

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Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus

Alfaifi

Alshahrani

Ahmad

et al. 2021

BMJ Open Diab Res Care

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BackgroundType 2 diabetes mellitus (T2DM) is a multifactorial disorder that leads to alterations in gene regulation. Long non-coding RNAs (lncRNAs) have become a major research topic as they are involved in metabolic disorders.MethodsThis study included a total of 400 study subjects; 200 were subjects with T2DM and 200 were healthy subjects. Extracted RNA was used to synthesize cDNA by quantitative real time. Serum analysis was carried out to determine differences in biochemical parameters. Recorded data were used to evaluate associations with expression of lncRNAs NF-kappaB interacting lncRNA (NKILA), nuclear enriched abundant transcript 1 (NEAT1), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and myocardial infarction-associated transcript (MIAT) in T2DM cases.ResultsCompared with healthy controls, patients with T2DM showed an overall increase in expression of lncRNAs NKILA, NEAT, MALAT1, and MIAT by 3.94-fold, 5.28-fold, 4.46-fold, and 6.35-fold, respectively. Among patients with T2DM, higher expression of lncRNA NKILA was associated with hypertension (p=0.001), smoking (p<0.0001), and alcoholism (p<0.0001). Altered NEAT1 expression was significantly associated with weight loss (p=0.04), fatigue (p=0.01), slow wound healing (p=0.002), blurred vision (p=0.008), loss of appetite (p=0.007), smoking (p<0.0001), and alcoholism (p<0.0001). Higher expression of lncRNA MALAT1 was significantly linked with weight loss (p=0.003), blurred vision (p=0.01), smoking (p<0.0001), and alcoholism (p<0.0001). Expression of lncRNA MIAT was associated with only blurred vision (p<0.0001), smoking (p<0.0001), and alcoholism (p<0.0001). Positive correlations of lncRNA NKILA with lncRNAs NEAT1 (r=0.42, p<0.0001), MALAT (r=0.36, p<0.0001) and MIAT (r=0.42, p<0.0001) were observed among patients with T2DM. Significant positive correlations of lncRNA NEAT with lncRNAs MALAT and MIAT were observed among patients with T2DM. A positive correlation between lncRNAs MALAT and MIAT was also observed among patients with T2DM.ConclusionIncreased circulating NKILA, NEAT1, MALAT, and MIAT expression in patients with T2DM, which is linked with poor patient outcomes and significantly linked with alcoholism and smoking, may influence the degree and severity of disease among patients with T2DM. These lncRNAs may contribute to the progression of T2DM disease or other related diabetes-related complications.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It was suggested that suppressing expression of the lncRNA NKILA may inhibit the development of DC. 27 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus

Alfaifi

Alshahrani

Ahmad

et al. 2021

BMJ Open Diab Res Care

View full text Add to dashboard Cite

show abstract

“…Although the specific intrinsic mechanism had not been fully elucidated, studies have confirmed that NKILA played an important role in inflammation. For instance, Li et al presented NKILA was up-regulated in diabetic cardiomyopathy and could restrain cell apoptosis [25]. Zhu et al presented NKILA played a proinflammatory response role in endothelium inflammation [26].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation

Wang

Zhang

Sun

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Background: Infantile pneumonia (IP) seriously affects the health of children. This article mainly discussed the protective effect of long non-coding RNA NKILA (lnc NKILA) on IP by detecting cell viability, apoptosis and inflammatory response of MRC5 cells. Methods: Cell counting kit-8 (CCK-8) was used to detect cell viability, while flow cytometry was used to detect cell apoptosis. The expression of apoptosis-associated factors (Bcl-2, Bax, PARP and Cleaved-PARP) and NF-jB and JNK pathway-related factors (t-IjBa, p-IjBa, t-p65, p-p65, b-actin, t-JNK and p-JNK) were tested by western blot. Otherwise, productions of inflammatory factors interleukin (IL)-1b and IL-6 were tested by enzyme-linked immunosorbent assay (ELISA) and western blot. Furthermore, RNA levels were respectively tested and changed by RT-qPCR and cell transfection. Results: Tumour necrosis factor-a (TNF-a) treatment reduced cell viability, induced cell apoptosis and promoted inflammatory factors expression. NKILA overexpression remitted TNF-a-induced injury. Moreover, NKILA positively regulated miR-21. miR-21 inhibition could weaken the functions of NKILA overexpression on TNF-a-induced injury. At last, NKILA and miR-21 were involved in the regulation of JNK and NF-jB pathways. Conclusions: NKILA overexpression remitted TNF-a-induced MRC5 cell injury by up-regulation of miR-21 and via inactivation of JNK and NF-jB signaling pathways. ARTICLE HISTORY

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LncRNA HCG18 affects diabetic cardiomyopathy and its association with miR-9-5p/IGF2R axis

Luo,

Jiang,

Zhong

et al. 2024

Heliyon

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LncRNA NKILA was upregulated in diabetic cardiomyopathy with early prediction values

Cited by 14 publications

References 21 publications

Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus

Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus

Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation

LncRNA HCG18 affects diabetic cardiomyopathy and its association with miR-9-5p/IGF2R axis

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