LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5

Yu, Lei; Zhang, Wei; Wang, Peng; Zhang, Qi; Cong, Aihua; Yang, Xiuyuan; Sang, Kai

doi:10.3892/etm.2021.10324

Cited by 20 publications

(11 citation statements)

References 32 publications

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“…Snhg11 has been proposed to act as a microRNA (miRNA) sponge [44,45]. In line with this role, the genes that are downregulated upon Snhg11 knockdown are highly enriched in targets of miRNAs predicted to bind Snhg11.…”

Section: Aso-mediated Knockdown Of Snhg11 In Vivo Leads To Trisomic-l...mentioning

confidence: 99%

The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse models

Sierra

Sabariego

Fernández-Blanco

et al. 2022

Preprint

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Down syndrome (DS) is the most common genetic cause of intellectual disability. Even though advances in the last decades have allowed better delineation of its pathogenetic mechanisms, its cellular and molecular bases are still poorly understood. Here, single-nuclei transcriptional profiles of the hippocampus of a DS mouse model revealed that the trisomy results in a highly cell-type specific alteration of the transcriptome. Strikingly, we observe a major transcriptomic shift in trisomic granule cells from the dentate gyrus (DG), without important changes in other hippocampal regions. We identified the small nucleolar RNA host gene 11, Snhg11, specifically downregulated in the trisomic DG, as the main contributor to the observed shift. Knockdown of Snhg11 in the DG of wild-type mice impairs synaptic function and adult neurogenesis and recapitulates trisomic hippocampal-dependent cognitive phenotypes. Our work highlights the importance of this long non-coding RNA in intellectual disability and reveals its functional involvement in the DG. These findings suggest the DG as a main region for the memory deficits observed in DS and indicate the relevance of new players such as long non-coding RNAs in its etiology.

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Section: Aso-mediated Knockdown Of Snhg11 In Vivo Leads To Trisomic-l...mentioning

confidence: 99%

The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse models

Sierra

Sabariego

Fernández-Blanco

et al. 2022

Preprint

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show abstract

“…CBX5 silencing can inhibit cell proliferation and metastasis, while overexpression promotes the proliferation and metastasis of TNBC cells, and can be regulated by miR-2335-5p/lncRNA SNHG11 signaling pathway. 33 These results together indicate that CBX5 plays a carcinogenic role in many cancers including BC.…”

Section: Discussionmentioning

confidence: 80%

Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer

Mao¹,

Zheng²,

Lin³

et al. 2021

IJGM

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Introduction: Breast cancer (BC) has become the malignant tumor with the highest incidence worldwide. As a critical components of epigenetic regulation complexes, chromobox (CBX) family members inhibit the transcription of target genes through chromatin modification, leading to the progression of various human diseases and cancers. So far, little is known about the role of different CBX members in BC, especially their association with immune cells. Methods: We conducted the analysis of differential expression of CBXs using Oncomine and GEPIA, prognostic value of CBXs using GEPIA and Kaplan-Meier, genetic interaction of CBXs using cBioPortal and GeneMANIA, and immune cell infiltration of CBXs in BC patients using TIMER. Results: The CBX2/3/4/8 expression levels were increased significantly, while the CBX6/7 expression levels were decreased. We found that CBX3 was significantly correlated with clinicopathological staging and short DFS in BC patients. High CBX3/5 expression was correlated with short OS in BC patients, while high expression of CBX4 was correlated with long OS in BC patients. In addition, the functions of CBXs family members mainly focus on methylated histone residue binding and chromatin organization. The CBXs expressions were closely related to the infiltration level of a variety of immune cells, including CD4/8+ T cells, B cells, neutrophils, macrophages and dendritic cells in BC cancers. The correlation between CBXs and immune cell infiltration was more common in Luminal BC than in Basal and Her-2 type. Conclusion:This study may provide a new understanding for selection of molecular typing, therapeutic and prognostic biomarkers of CBX family in BC.

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“…XIST enhanced the chemoresistance and tumorigenesis of CRC by adsorbing miR-125b-2-3p and elevating WEE1 [24]. Previous studies reported that SNHG11 acted as a contributor in triple-negative breast cancer [25], hepatocellular carcinoma [26] and pancreatic carcinoma [27] through different pathways. Moreover, SNHG11 was able to exacerbate CRC malignancy [28,29].…”

Section: Discussionmentioning

confidence: 99%

LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis

et al. 2022

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Long noncoding RNAs (lncRNAs) have been reported to serve as vital regulators in the chemoresistance of human cancers, including colorectal cancer (CRC). In this study, we aimed to explore the functions of lncRNA small nucleolar RNA host gene 11 (SNHG11) in the resistance of CRC to bevacizumab. Quantitative real-time PCR, western blot assay or immunohistochemistry assay were performed to examine the expression of SNHG11, microRNA-1207-5p (miR-1207-5p), ATP binding cassette subfamily C member 1 (ABCC1) and Ki67. Cell Counting Kit-8 assay was conducted to evaluate bevacizumab resistance and cell viability. 5′-ethynyl-2′-deoxyuridine analysis, flow cytometry analysis and wound-healing assay were conducted for cell proliferation, apoptosis and migration, respectively. Dual-luciferase reporter assay and RNA immunoprecipitation assay were employed to analyze the relations among SNHG11, miR-1207-5p and ABCC1. Murine xenograft model assay was employed to analyze bevacizumab resistance in vivo. The exosomes were observed under transmission electron microscopy. SNHG11 was overexpressed in bevacizumab-resistant CRC tissues and cells. Knockdown of SNHG11 restrained bevacizumab resistance, repressed cell proliferation and migration, and promoted apoptosis in bevacizumab-resistant CRC cells. MiR-1207-5p served as the target of SNHG11 and SNHG11 regulated bevacizumab resistance by targeting miR-1207-5p. ABCC1 was the target gene of miR-1207-5p. Overexpression of miR-1207-5p inhibited bevacizumab resistance and cell progression in bevacizumab-resistant CRC cells, with ABCC1 elevation abrogated the impacts. SNHG11 silencing repressed bevacizumab resistance in vivo. In addition, exosomal SNHG11 was upregulated in bevacizumab-resistant CRC cells. SNHG11 contributes to bevacizumab resistance in CRC depending on the modulation of miR-1207-5p and ABCC1.

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LncRNA SNHG11 aggravates cell proliferation and migration in triple‑negative breast cancer via sponging miR‑2355‑5p and targeting CBX5

Cited by 20 publications

References 32 publications

The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse models

The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse models

Bioinformatic Analysis of Prognostic Value, Genetic Interaction, and Immune Infiltration of Chromobox Family Proteins in Breast Cancer

LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis

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