LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers

Xiao, Yuhang; Xiao, Ta; Ou, Wei; Wu, Zhining; Wu, Jie; Tang, Jinming; Tian, Bo; Zhou, Yong; Su, Min; Wang, Wenxiang

doi:10.1186/s40364-020-00221-4

Cited by 32 publications

(23 citation statements)

References 68 publications

(131 reference statements)

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“…In recent years, scientists have focused on molecular biomarkers in the development of a reliable prognostic biomarker in cancer [16]. The long noncoding RNA (lncRNA) is a type of noncoding RNA with transcripts of >200 nucleotides in length without any protein-coding capacity [17], but it plays important roles in the regulation of mRNA transcription and protein translation [18].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Nine-Redox-Related Long Noncoding RNA Signature in Renal Clear Cell Carcinoma

Xia

Yang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Redox plays an essential role in the pathogeneses and progression of tumors, which could be regulated by long noncoding RNA (lncRNA). We aimed to develop and verify a novel redox-related lncRNA-based prognostic signature for clear cell renal cell carcinoma (ccRCC). Materials and Methods. A total of 530 ccRCC patients from The Cancer Genome Atlas (TCGA) were included in this study. All the samples were randomly split into training and test group at a 1 : 1 ratio. Then, we screened differentially expressed redox-related lncRNAs and constructed a novel prognostic signature from the training group using the least absolute shrinkage and selection operation (LASSO) and COX regression. Next, to verify the accuracy of the signature, we conducted risk and survival analysis, as well as the construction of ROC curve, nomogram, and calibration curves in the training group, test group, and all samples. Finally, the redox gene-redox-related lncRNA interaction network was constructed, and gene set enrichment analysis (GSEA) was performed to investigate the status of redox-related functions between high/low-risk groups. Results. A nine-redox-related lncRNA signature consisted of AC025580.3, COLCA1, AC027601.2, DLEU2, AC004918.3, AP006621.2, AL031670.1, SPINT1-AS1, and LAMA5-AS1 was significantly associated with overall survival in ccRCC patients. The signature proved efficient, and thus, a nomogram was successfully assembled. In addition, the GSEA results demonstrated that two major redox-related functions were enhanced in the high-risk group ccRCC patients. Conclusions. Our findings robustly demonstrate that the nine-redox-related lncRNA signature could serve as an efficient prognostic indicator for ccRCC.

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Section: Introductionmentioning

confidence: 99%

Development and Validation of a Nine-Redox-Related Long Noncoding RNA Signature in Renal Clear Cell Carcinoma

Xia

Yang

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Currently, lncRNA-based therapies are being developed mainly in the cancer and cardiovascular fields [ 106 – 111 ]. Two main approaches are used: knockdown of lncRNAs from natural antisense transcript (NAT) subclasses and interference with lncRNA/PRC2 interactions [ 112 ].…”

Section: The Role and Function Of Lncrnas In Diabetic Inflammationmentioning

confidence: 99%

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

Huang

2021

International Journal of Endocrinology

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Diabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. This paper presents a brief review of studies on the mechanisms of lncRNAs in diabetic inflammation. The purpose of this article is to determine the role of lncRNAs in the process of diabetic inflammation and to provide new strategies for the use of lncRNAs in the treatments for diabetic inflammation.

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“…They mainly summarized the relationship between SNHG1 and cancer and revealed that SNHG1 may act as a useful biomarker for the diagnosis, prognosis and treatment of human cancer. In addition, SNHG5, SNHG7, SNHG12, and SNHG16 have all been reported to promote the progression of cancers [ 15 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA SNHG4: a novel target in human diseases

Chu

Zheng

et al. 2021

Cancer Cell Int

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Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple studies have been published on the relationship between lncRNA expression and the progression of human diseases. LncRNA small nucleolar RNA host gene 4 (SNHG4), a member of the lncRNA SNHG family, is abnormally expressed in a variety of human diseases, including gastric cancer, renal cell carcinoma, glioblastoma, neuroblastoma, prostate cancer, colorectal cancer, osteosarcoma, cervical cancer, liver cancer, lung cancer, non-small-cell lung cancer, neonatal pneumonia, diabetic retinopathy, neuropathic pain, acute cerebral infarction, acute myeloid leukaemia, and endometriosis. In this paper, the structure of SNHG4 is first introduced, and then studies in humans, animal models and cells are summarized to highlight the expression and function of SNHG4 in the above diseases. In addition, the specific mechanism of SNHG4 as a competing endogenous RNA (ceRNA) is discussed. The findings indicate that SNHG4 can be used as a biomarker for disease prognosis evaluation and as a potential target for disease diagnosis and treatment.

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LncRNA SNHG16 as a potential biomarker and therapeutic target in human cancers

Cited by 32 publications

References 68 publications

Development and Validation of a Nine-Redox-Related Long Noncoding RNA Signature in Renal Clear Cell Carcinoma

Development and Validation of a Nine-Redox-Related Long Noncoding RNA Signature in Renal Clear Cell Carcinoma

Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

Long noncoding RNA SNHG4: a novel target in human diseases

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