LncRNA SNHG17 promotes gastric cancer progression by epigenetically silencing of p15 and p57

Zhang, Guohua; Xü, Ying; Wang, Sijia; Gong, Zhigang; Zou, Chen; Zhang, Heng; Ma, Guansheng; Zhang, Wenbo; Jiang, Pengcheng

doi:10.1002/jcp.27320

Cited by 73 publications

(79 citation statements)

References 43 publications

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“…Aberrant expression of SNHG17 has been reported to play oncogenic role in several cancers by regulating cancer cell proliferation, migration and metastasis [11][12][13]26]. However, the role of SNHG17 in BC is not well known.…”

Section: Discussionmentioning

confidence: 99%

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Long non-coding RNASNHG17 promotes the progression of breast cancer by sponging miR-124-3p

Wei

Hong

et al. 2020

Cancer Cell Int

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Background: Small nucleolar RNA host gene 17 (SNHG17), a novel cancer-related long noncoding RNA (lncRNA), was reported to be responsible for processing and developing in several cancers. Nonetheless, the clinical significance and biological function of SNHG17 in human breast cancer (BC) remain rarely known. Materials and methods: 58 pairs of BC tissues and adjacent non-cancerous tissues were harvested to measure SNHG17 expression levels. SNHG17 was knockdown to study its biological behavior in BC cells. The microRNAs (miR-NAs) that can bind to SNHG17 were predicated using Starbase2.0 and were tested using luciferase reporter activity and RIP assays. A xenograft model was established to investigate the impact of SNHG17 in tumor growth in vivo. Results: An increased SNHG17 was observed in BC samples and cell lines compared with corresponding control. Increased SNHG17 was closely associated with poor prognosis.SNHG17 depletion suppressed cell proliferation, migration and invasion in vitro, as well as inhibited tumor growth in xenograft tumor models. Mechanistically, SNHG17 could function as an endogenous sponge of miR-124-3p in BC cells. Moreover, the repression of cell proliferation, migration and invasion induced by SNHG17 knockdown would reversed by miR-124-3p inhibitor. Conclusion: The present study demonstrated that the lncRNASNHG17 could regulate the progression of BC by sponging miR-124-3p.

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Section: Discussionmentioning

confidence: 99%

“…Small nucleolar RNA Host Gene 17 (SNHG17), an important lncRNA, was proven to play oncogenic role in non-small cell lung cancer [11], gastric cancer [12], colorectal cancer [13] and melanoma [14]. However, the biological function of SNHG17 in the initiation and development of BC remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNASNHG17 promotes the progression of breast cancer by sponging miR-124-3p

Wei

Hong

et al. 2020

Cancer Cell Int

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“…It has been also been reported to that SNHG3-related ceRNAs can be potential research targets to explore the molecular mechanisms of HCC [30]. Moreover, SNHG17 is involved in gastric cancer, non-small-cell lung cancer, or melanoma through regulation of pathways, such as the phosphoinositide 3-kinase (PI3K)-AKT pathway [31][32][33]. However, until, little has been published of these snoRNAs or SNHGs in EC.…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of small nucleolar RNAs (snoRNAs) associated co-expression and ceRNA regulatory networks in esophageal carcinoma

Jiang¹,

Zhuang²,

Yang³

et al. 2020

Preprint

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Background: This study aimed to investigate the role of small nucleolar RNAs (snoRNAs) and their host genes (SNHGs) in tumorigenesis and progression of esophageal carcinoma (EC). Methods: RNA-seq data and clinical information for EC patients were obtained from The Cancer Genome Atlas database. Differentially expressed snoRNAs (DE-snoRNAs) and SNHGs (DE-SNHGs) between EC samples and normal controls were screened with the edgeR package, followed by the trend analysis with STEM. Survival analysis was performed using the Kaplan–Meier method with the log-rank test. Identification of co-expressed genes and functional enrichment analyses were performed with Pearson’s correlation analysis and enrichment analysis, respectively. Lastly, the co-expression and ceRNA networks were constructed. Results: A total of 19 DE-snoRNAs and nine DE-SNHGs were identified between EC samples and normal controls. Moreover, two snoRNA clusters related to the clinic stage were identified through trend analysis. Survival analysis results demonstrated that SNORA70D was significantly associated with the overall survival of EC patients (P=0.034). In addition, a co-regulation network that included six snoRNAs and 29 mRNAs was constructed. A ceRNA network comprised of five SNHGs, 11 mRNAs, and 38 miRNAs was constructed based on the top 50 relationship pairs. KEGG pathway enrichment analysis revealed that SNORA14B, SNORA47, SNORA71C, SNORD12B, and SNORD14E in the co-expression network were mainly enriched in the NOD−like receptor signaling pathway, and neuroactive ligand−receptor interaction pathway. SNHG23, SNHG3, SNHG17, SNHG4, and SNHG8 in the ceRNA regulation network were mainly enriched in calcium signaling pathway, cytokine−cytokine receptor interaction, and the extracellular matrix−receptor interaction pathway. Conclusion: The data revealed a series of snoRNAs, SNHGs, and pathways involved in EC carcinogenesis, which will provide a basis for understanding the underlying molecular mechanism of EC development.

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“…High expression of SNHG17 was significantly associated with tumor invasion, lymph node metastases, and advanced TNM stage. SNHG17 was reported to promote the capability of proliferation, invasion, and migration cells in vitro and inhibited apoptosis via regulating cyclin-dependent protein kinase inhibitors, including p15 and p57 (Zhang et al, 2019).…”

Section: External Data Validationmentioning

confidence: 99%

A prognostic eight‐lncRNA expression signature in predicting recurrence of ER‐positive breast cancer receiving endocrine therapy

Tang

Cui

Zhang

et al. 2019

Journal Cellular Physiology

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Long noncoding RNAs (lncRNAs) have the main role in the tumorigenesis of breast cancer. In the present study, lncRNA expression profiling was collected to identify a lncRNA expression signature from the Gene Expression Omnibus database. An eight-lncRNA signature was established to predict the survival of patients with estrogen receptor (ER)-positive breast cancer receiving endocrine therapy. Patients were separated into a low-risk group and a high-risk group based on this signature. Patients in high-risk group have worse survival compared to those in low-risk group using Kaplan-Meier curve analysis with log-rank test. Receiver operating characteristic analysis suggested good diagnostic efficiency of the eight-lncRNA signature. When adjusting the clinical features, including age, grade, lymph node status, and tumor size, this signature was independently associated with the relapse-free survival. The prognostic value of the lncRNA prognostic model was then validated in validation sets. When validated in a cohort of patients treated with neoadjuvant chemotherapy and endocrine therapy, this signature demonstrated good performance as well. Besides, we have built a nomogram that integrated the conventional clinicopathological features and the eight-lncRNA-based signature. To sum up, our results indicated that the eight-lncRNA prognostic model was a reliable tool to group patients at high and low risk of disease relapse. This signature may have possible implication in prognostic evaluations of patients with ER-positive breast cancer receiving endocrine therapy. K E Y W O R D S breast cancer, lncRNA, nomogram, prognosis

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LncRNA SNHG17 promotes gastric cancer progression by epigenetically silencing of p15 and p57

Cited by 73 publications

References 43 publications

Long non-coding RNASNHG17 promotes the progression of breast cancer by sponging miR-124-3p

Long non-coding RNASNHG17 promotes the progression of breast cancer by sponging miR-124-3p

Identification and analysis of small nucleolar RNAs (snoRNAs) associated co-expression and ceRNA regulatory networks in esophageal carcinoma

A prognostic eight‐lncRNA expression signature in predicting recurrence of ER‐positive breast cancer receiving endocrine therapy

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