lncRNA‑SNHG7‑003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR‑1306‑5p/SIRT7 signaling pathway

lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

“…Given that miR-1306-5p targets SIRT7 gene, we speculated that it regulates progression of OS by binding SIRT7. 10 Indeed, further analyses revealed a strong negative correlation between miR-1306-5p and SIRT7 expression in OS tissue ( Figure 6A ; r = - 0.3177; P < 0.01). Interestingly, we observed a positive correlation between AC007207.2 and SIRT7 expression ( Figure 6B ; r = 0.3366; P < 0.01).…”

“… 14 MiR-1306-5p regulates numerous biological processes under multiple diseases pathologies. 10 , 15 , 16 For instance, Zheng et al revealed that miR-1306-5p regulates proliferation, migration and invasion of vascular smooth muscle cells by targeting lncRNA SNHG7-003. 10 Elsewhere, Genis et al found that the expression of miR-1306-5p was strongly associated with prognosis of patients with cardiovascular complications.…”

“… 10 , 15 , 16 For instance, Zheng et al revealed that miR-1306-5p regulates proliferation, migration and invasion of vascular smooth muscle cells by targeting lncRNA SNHG7-003. 10 Elsewhere, Genis et al found that the expression of miR-1306-5p was strongly associated with prognosis of patients with cardiovascular complications. 17 However, the role of miR-1306-5p in cancer tissues is not well understood.…”

“…Given that miR-1306-5p targets SIRT7 gene, we speculated that it regulates progression of OS by binding SIRT7. 10 Indeed, further analyses revealed a strong negative correlation between miR-1306-5p and SIRT7 expression in…”

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“…Sun et al claimed that inhibition of lncRNA H19 reduced VSMC proliferation and increased apoptosis, which helped slow down atherosclerosis (Sun et al, 2020). Zheng et al found that overexpression of SNHG7 targeted and inhibited miR-1306-5p/Sirtuin7, reducing excessive proliferation, migration and invasion of VSMCs induced by oxidized low-density lipoprotein and alleviating atherosclerosis (Zheng et al, 2021). Some scholars have also stated that LINC00961 is a potential target for the treatment of atherosclerosis.…”