2022
DOI: 10.1186/s12935-021-02418-5
|View full text |Cite
|
Sign up to set email alerts
|

LncRNA TP73‐AS1 promotes nasopharyngeal carcinoma progression through targeting miR-342-3p and M2 polarization via exosomes

Abstract: Background Nasopharyngeal carcinoma (NPC) is a deadly cancer, mainly presenting in southeast and east Asia. Long noncoding RNAs (lncRNAs) play essential roles in cancer progression. Exosomes are critical for intercellular communication. Thus, the aim of this study was to identify the functional lncRNAs in NPC and its relevant mechanisms. Methods Data from public databases were utilized to screen for functional lncRNAs in NPC. Functional and mechani… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
8
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 20 publications
(8 citation statements)
references
References 59 publications
0
8
0
Order By: Relevance
“…During this transfer, the rate of proliferation and production of cytokines in non-exhausted TCD8 + cells decreases, and the levels of inhibitory markers such as PD-1 and TIM-3 increase at their surfaces [76,77]. Because lncRNAs are the main factor in this action, exosomes must integrate with the target cell membrane [78].…”
Section: T Lymphocytes-derived Exosomesmentioning
confidence: 99%
“…During this transfer, the rate of proliferation and production of cytokines in non-exhausted TCD8 + cells decreases, and the levels of inhibitory markers such as PD-1 and TIM-3 increase at their surfaces [76,77]. Because lncRNAs are the main factor in this action, exosomes must integrate with the target cell membrane [78].…”
Section: T Lymphocytes-derived Exosomesmentioning
confidence: 99%
“…As for NPC-lncRNAs, lncRNA-LINC00460 and lncRNA PVT1 have been involved in glucose metabolism and susceptibility to T cell-mediated lysis of NPC cells [66][67][68]. LncRNA TP73-AS1 is carried from NPC cells by extracellular vesicles and is associated with the polarization of macrophage toward the M2 phenotype [69]. TP73-AS1 is associated with a variety of cancers, so presumably, TP73-AS1 may be an NPC potential target [70][71][72].…”
Section: Indirect Interactions Between Cells I Exosomesmentioning
confidence: 99%
“…Mechanistically, HMMR-AS1 interacts with miR-147a to reduce ARID3A degradation after which M2 macrophage polarization and the development of HCC are promoted ( 77 ). In addition, lncRNA TP73-AS1 is highly expressed in nasopharyngeal carcinoma cell-derived EVs, which binds to miR-342-3p, promotes the M2 polarization of macrophages, and reinforces the motility and microtubule formation of macrophages ( 78 ). Furthermore, FGD5-AS1 enriched in pancreatic cancer cell-derived EVs mediates M2 polarization of macrophages by activating STAT3/NF-κB pathway ( 79 ).…”
Section: Macrophagementioning
confidence: 99%