LncRNA UCA1 promoted cisplatin resistance in lung adenocarcinoma with HO1 targets NRF2/HO1 pathway

Shi, Wenjing; Ling, Liqun; Li, Changhong; Wu, Ruihao; Zhang, Meijuan; Shao, Fanggui; Wang, Yumin

doi:10.1007/s00432-022-04152-5

Cited by 9 publications

(3 citation statements)

References 35 publications

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“…Through regulating the miR-495/nrf2 axis, UCA1 has been found to confer cisplatin resistance [ 32 ]. UCA1 was also confirmed to exert DDP resistance in LUAD by modulating Heme oxygenase1 (HO1) targets the UCA1/NRF2-HO1 pathway [ 33 ].…”

Section: Lncrnas and Resistance To Platinum Drugsmentioning

confidence: 99%

Long non-coding RNA and Evolving drug resistance in lung cancer

Wang,

Fu,

Zhong

et al. 2023

Heliyon

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Section: Lncrnas and Resistance To Platinum Drugsmentioning

confidence: 99%

Long non-coding RNA and Evolving drug resistance in lung cancer

Wang,

Fu,

Zhong

et al. 2023

Heliyon

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“…10 In recent times, in-depth research has discovered that lncRNAs have a significant impact on the formation and progression of tumors by engaging with various molecules. [11][12][13][14] Furthermore, lncRNAs play a role in the growth and infiltration of LUAD cells, resistance to chemotherapy, metastasis, and proliferation. 15 This indicate that lncRNAs could potentially function as indicators for predicting, diagnosing, and prognosing lung cancer.…”

Section: Introductionmentioning

confidence: 99%

“…lncRNAs, also known as long noncoding RNAs, consist of over 200 nucleotides and are incapable of being translated into functional proteins 10 . In recent times, in‐depth research has discovered that lncRNAs have a significant impact on the formation and progression of tumors by engaging with various molecules 11–14 . Furthermore, lncRNAs play a role in the growth and infiltration of LUAD cells, resistance to chemotherapy, metastasis, and proliferation 15 .…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of m6A modification patterns and m6A‐related lncRNAs as potential biomarkers in lung adenocarcinoma

Wang,

Gu,

et al. 2023

Environmental Toxicology

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BackgroundN6‐methyladenosine (m6A) methylation is considered to induce tumor cell proliferation, migration, and apoptosis. Understanding the mechanism of m6A‐related lncRNAs in the development of lung adenocarcinoma (LUAD) may help predict prognosis.Methodsm6A‐related lncRNAs related to lung cancer were identified and combined with the MeRIP‐Seq dataset. The consensus clustering method was utilized to divide LUAD patients, and prognostic model was constructed using the Lasso Cox algorithm. The cluster profiler package was used for gene ontology and KEGG enrichment. The proportion of immune infiltration was estimated using the CIBERSORT algorithm. The decision tree was constructed by the rpart package, and nomograms were built by the rms package. The Connectivity Map database was analyzed for the therapeutic effects of small molecule drugs for LUAD. In addition, qPCR, colony formation and transwell assays were performed to validate functions of m6A‐associated lncRNAs.ResultsNineteen m6A‐modified lncRNAs in LUAD were identified. LUAD patients were divided into two categories based on the expression of 19 m6A‐related lncRNAs. Cluster 2 patients had better antigen production and expression, while naive B cells, plasma cells, and activated NK cells were lower in cluster 1. Nine m6A‐related lncRNAs were selected to establish a risk model for evaluating the prognosis of LUAD patients. The high‐risk group had higher tumor mutational burden and lower TIDE scores with more gamma delta T cells and neutrophils. Nomograms showed that the prognostic model had predominant predictive ability for LUAD patients based on the risk score analyzed by the decision tree model. Benzo(a)pyrene and neurodazine might improve the prognosis of LUAD patients. The qRT‐PCR results confirmed the reliability of the analytical results.ConclusionThe establishment of a prognostic model of m6A‐related lncRNAs can independently predict overall survival in LUAD and may help to develop personalized immunotherapy strategies.

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