LncRNA XIST regulates myocardial infarction by targeting miR‐130a‐3p

Zhou, Tao; Qin, Guo‐Wei; Yang, Liehong; Xiang, Dingcheng; Li, Suining

doi:10.1002/jcp.26327

Cited by 76 publications

(58 citation statements)

References 26 publications

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“…Increasing evidences showed that lncRNA Xist was reported as an oncogene in various tumors [39,40]. Moreover, recent studies indicated the involvement of lncRNA Xist in myocardial infarction [41]. In this study, lncRNA Xist serve as a sponge of miR-19a-3p in BMSCs, and lncRNA Xist regulated Hoxa5 expression and BMSCs osteogenic differentiation via targeting miR-19a-3p directly.…”

Section: Discussionmentioning

confidence: 58%

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Chen¹,

Li²,

Zhi³

et al. 2020

Aging and disease

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The switch between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a key role in aging-induced osteoporosis. In this study, miR-19a-3p was obviously downregulated in BMSCs from aged humans and mice. Overexpressed miR-19a-3p evidently reduced aginginduced bone loss in mice and promoted osteogenic differentiation of BMSCs, while silenced miR-19a-3p manifestly increased aging-induced bone loss in mice and repressed osteogenic differentiation of BMSCs. Hoxa5 was significantly downregulated in the BMSCs from aged mice and contribute to miR-19a-3p-induced osteoblast differentiation as a direct target gene of miR-19a-3p. Furthermore, lncRNA Xist was found as a sponge of miR-19a-3p to repress BMSCs osteogenic differentiation. In conclusion, our study reveals the critical role of the lncRNA Xist/miR-19a-3p/Hoxa5 pathway in aging-induced osteogenic differentiation of BMSCs, indicating the potential therapeutic target for osteoporosis.

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Section: Discussionmentioning

confidence: 58%

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Chen¹,

Li²,

Zhi³

et al. 2020

Aging and disease

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“…Recently, Guo et al showed that LINC00528 was one of the most upregulated lncRNA in MI tissues compared to normal tissues [15]. Zhou et al revealed that LINC00528 was one of the most upregulated lncRNA in CHD tissues compared with normal tissues [14]. However, the roles and underlying mechanisms of LINC00528 in MI progression remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…LncRNAs have been highlighted as key factors in the progression of AMI. Recently, studies showed that LINC00528 was one of the most upregulated lncRNA in coronary heart disease [14,15]. However, the roles and underlying mechanisms of LINC00528 in MI remain unclear.…”

Section: Linc00528 Expression In MImentioning

confidence: 99%

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis

2019

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This study is aimed to explore the roles of LINC00528 in myocardial infarction (MI) progression. Quantitative real-time PCR showed that the expression of LINC00528 and COX-2 was upregulated while miR-143-3p expression was down-regulated in post-MI cells. In function assays, LINC00528 suppression promoted post-MI cells proliferation and reduced cell apoptosis in vitro. In mechanism, LINC00528 interacted with miR-143-3p in post-MI cells. COX-2 served as a target of miR-143-3p in post-MI cells. Besides, LINC00528 inhibition on COX-2 expression and post-MI cells progression could be partially abolished by miR-143-3p inhibitors. Therefore, our findings suggested that LINC00528 exerted its regulatory roles in MI via the miR-143-3p/COX-2 axis, which provided a potential therapeutic target for MI patients treatment. ARTICLE HISTORY

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“…Zhou et al demonstrated XIST promoted myocardial infraction by targeting miR-130a-3p [7]. knockdown of lncRNA MIAT was identified to inhibit angiotensin II (Ang-II)-induced cardiac hypertrophy by targeting miR-93/TLR4 axis [8].…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA XR007793 Regulates Proliferation and Migration of Vascular Smooth Muscle Cell via Suppressing miR-23b

Zhang

Cui

et al. 2018

Med Sci Monit

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BackgroundLong noncoding RNAs (lncRNAs) were identified as potential regulatory factor in vascular disease. However, the role of XR007793 in the regulation of neointima formation after vascular injury remains largely unknown.Material/MethodsLncRNA expression levels were detected using real-time polymerase chain reaction (RT-PCR). In vivo and in vitro assay were performed in Sprague-Dawley rats and VSMCs. Cell Counting Kit-8 (CCK-8) assay, Transwell assay, and scratch wound healing assay were performed to detect cell proliferation and migration. Western blotting was used to detect protein expression.ResultsThe results of qRT-PCR indicated that XR007793 expression was significantly increased in the injured carotid artery of Sprague-Dawley rats and platelet-derived growth factor-BB induced rat aortic smooth muscle cells. Knockdown of XR007793 repressed the proliferation and migration of VSMC in vitro. The expression level of miR-23b was reduced in mouse carotid injured tissues and cell line. Bioinformatics analysis and luciferase reporter assay revealed that XR007793 directly bonds to miR-23b. Pearson correlation analysis showed that XR007793a and miR-23b were negatively correlated in carotid samples. Furthermore, bioinformatics analysis and luciferase assay indicated that miR-23b targeted the Forkhead box O 4 (FOXO4) 3′-UTR to inhibit FOXO4 expression. After transfecting miR-23b inhibitor, the expression both of XR007793 and FOXO4 was increased. The effects on expression were reversed after transfected with miR-23b mimics. Rescue experiments results indicated that miR-23b inhibitor reduced the expression of VSMC marker and promoted proliferation and migration of VSMC.ConclusionsThis study shows that XR007793 aggravates the loss of function of VSMCs by negatively regulating miR-23b. It does so by targeting FOXO4, which could serve as a novel therapeutic target in post-angioplasty restenosis.

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LncRNA XIST regulates myocardial infarction by targeting miR‐130a‐3p

Cited by 76 publications

References 26 publications

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis

Long Noncoding RNA XR007793 Regulates Proliferation and Migration of Vascular Smooth Muscle Cell via Suppressing miR-23b

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