lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis

Ni, Wenchang; Li, Zhen; Ai, Kui

doi:10.1080/21655979.2021.2021346

Cited by 8 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional experiments measured cell proliferation, apoptosis, and migration. Additionally, the luciferase assay validated the relation of ZFPM2-AS1, miR-511-3p, and PAX6 [ 43 ]. With the attention to confirm that PAX6 is modulated by miR-708a/miR-148, we firstly compared PAX6 levels in atrial water from HM patients and cataract patients by RT-qPCR and ELISA, which revealed elevated PAX6 in serum of neonatal retinopathy patients relative to healthy participants.…”

Section: Discussionmentioning

confidence: 99%

The Connection between High Myopia Patients and MiR-708a or MiR-148 Expression Levels in Aqueous Studies of Visual Acuity

Shen¹,

Hong²,

Yu³

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Myopia goes far beyond the inconvenience it brings. It is a prevailing and vision-threatening eye disease, especially in Asia. Aberrantly expressed miR-708a and miR-148 are critical for accurate diagnosis, good prognosis, and precise response prediction of myopia. In this paper, we aim to examine the potential contributions of miR-708a, miR-148a, and PAX6 to high myopia (HM). First, aqueous samples were taken from 25 exclusively HM eyes and 25 exclusively cataract eyes. For next-generation sequencing and bioinformatics analysis, RNA from sample 30one was used. Twenty more samples were used for RT-qPCR. 341 miRNAs in total were found in HM eyes; 249 mature miRNAs and 17 new miRNAs showed differential expression. The expression of hsa-miR-127-3p, hsa-let-7i-5p, and hsa-miR-98-5p was identified using RT-qPCR. MiR-708a and miR-148, which may be linked to the development of myopia and serve as possible biomarkers, are notably highly expressed in atrial tissues of HM patients. Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM.

show abstract

Section: Discussionmentioning

confidence: 99%

The Connection between High Myopia Patients and MiR-708a or MiR-148 Expression Levels in Aqueous Studies of Visual Acuity

Shen¹,

Hong²,

Yu³

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…For example, overexpression of miRNA148a inhibited the expression of WNT1 protein in non-small cell lung cancer [ 27 ]; MIR-802 targeted MYLIP to inhibit the growth of cervical cancer cells [ 28 ]; and lncRNA SNHG3 regulated osteosarcoma invasion and migration through miRNA-151a-3p/RAB22A axis [ 29 ]. However, miRNAs are involved in far more cancers than these, including pancreatic cancer [ 30 ], retinoblastoma [ 31 ], melanoma [ 32 ], nasopharyngeal carcinoma [ 33 ], prostate cancer [ 34 ], bladder cancer [ 35 ], and breast cancer [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of key miRNAs and a microRNA-mRNA regulatory network associated with liver cancer

Tang,

Li,

Zhou

et al. 2024

Cell Cycle

View full text Add to dashboard Cite

MiRNAs play crucial regulatory roles in the growth and development of tumor cells by serving as carriers of post-transcriptional regulatory information derived from genes. Investigating the potential function and clinical significance of miRNA-mediated mRNA regulatory networks in liver cancer can offer novel insights and therapeutic strategies for the treatment of this disease. We identified 300 differentially expressed miRNAs, and five miRNAs were identified to be correlated with overall survival and could be used as an independent prognostic. GO enrichment analysis mainly included carboxylic acid biosynthesis, organic acid biosynthesis, peroxisomal membrane, microsomal membrane, DNA binding, C-acyltransferase activity, etc. KEGG enrichment analysis showed that the pathways of target genes related to liver cancer were mainly focused on butyric acid metabolism and partial amino acid metabolism. Eight of the top 10 HUB genes were associated with prognosis, and the expression of four genes was positively correlated with prognosis, of which ABAT, BHMT, and SHMT1 were target genes of hsa-miR-5003-3p. MiR-5003-3p inhibits ABAT/BHMT/SHMT1 expression, thereby promoting liver cancer development. Overall, our study provides new ideas for the treatment of liver cancer, and these five miRNAs may be independent prognostic biomarkers and therapeutic targets for liver cancer patients. And miR-5003-3p may be a critical factor in the mechanism of liver cancer development.

show abstract

“…NRIR , ZFPM2-AS1 , and LINC01215 expression levels were down-regulated in si LGALS1 HEMECs. ZFPM2-AS1 has been shown to play crucial roles in the progression of retinoblastoma, an angiogenesis-associated disease [ 45 ]. The interferon (IFN) family of cytokines serves as pivotal regulators of angiogenesis [ 46 ], while NRIR was found to be a negative Regulator of IFN Response [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Galectin-1-dependent ceRNA network in HRMECs revealed its association with retinal neovascularization

et al. 2023

View full text Add to dashboard Cite

Background Retinal neovascularization (RNV) is a leading cause of blindness worldwide. Long non-coding RNA (lncRNA) and competing endogenous RNA (ceRNA) regulatory networks play vital roles in angiogenesis. The RNA-binding protein galectin-1 (Gal-1) participates in pathological RNV in oxygen-induced retinopathy mouse models. However, the molecular associations between Gal-1 and lncRNAs remain unclear. Herein, we aimed to explore the potential mechanism of action of Gal-1 as an RNA-binding protein. Results A comprehensive network of Gal-1, ceRNAs, and neovascularization-related genes was constructed based on transcriptome chip data and bioinformatics analysis of human retinal microvascular endothelial cells (HRMECs). We also conducted functional enrichment and pathway enrichment analyses. Fourteen lncRNAs, twenty-nine miRNAs, and eleven differentially expressed angiogenic genes were included in the Gal-1/ceRNA network. Additionally, the expression of six lncRNAs and eleven differentially expressed angiogenic genes were validated by qPCR in HRMECs with or without siLGALS1. Several hub genes, such as NRIR, ZFPM2-AS1, LINC0121, apelin, claudin-5, and C-X-C motif chemokine ligand 10, were found to potentially interact with Gal-1 via the ceRNA axis. Furthermore, Gal-1 may be involved in regulating biological processes related to chemotaxis, chemokine-mediated signaling, the immune response, and the inflammatory response. Conclusions The Gal-1/ceRNA axis identified in this study may play a vital role in RNV. This study provides a foundation for the continued exploration of therapeutic targets and biomarkers associated with RNV.

show abstract

lncRNA ZFPM2-AS1 promotes retinoblastoma progression by targeting microRNA miR-511-3p/paired box protein 6 (PAX6) axis

Cited by 8 publications

References 42 publications

The Connection between High Myopia Patients and MiR-708a or MiR-148 Expression Levels in Aqueous Studies of Visual Acuity

The Connection between High Myopia Patients and MiR-708a or MiR-148 Expression Levels in Aqueous Studies of Visual Acuity

Identification and validation of key miRNAs and a microRNA-mRNA regulatory network associated with liver cancer

Galectin-1-dependent ceRNA network in HRMECs revealed its association with retinal neovascularization

Contact Info

Product

Resources

About