LncRNA ZNF674-AS1 Hinders Proliferation and Invasion of Hepatic Carcinoma Cells through the Glycolysis Pathway

Li, Dongliang; Xie, Yan; Sun, Jisan; Zhang, Li; Jiang, Wentao

doi:10.1155/2022/8063382

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Long noncoding RNA (lncRNA), circular RNA (circRNA) and microRNA targeting PKM2 to affect HCC tumorigenesis and development are one of the current research hotspots. [36,45] noncoding RNA can target PKM2's metabolic enzyme function to affect liver cancer cell metabolic reprogramming, [46][47][48] but also target PKM2's non-metabolic enzyme function to affect HCC tumorigenesis and development. [49,50] Wang C et al [49] found that lncRNA HULC can increase CCND1 expression by miR675-autophagy-PKM2 pathway, further affecting pRB and P21 WAF1/CIP1 expression and increasing liver cancer stem cell proliferation.…”

Section: Noncoding Rna Regulates Pkm2 Non-metabolic Enzyme Functionmentioning

confidence: 99%

Section: The Effect Of Regulating Pkm2 Non-metabolic Enzyme Function ...mentioning

confidence: 99%

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Non-metabolic enzyme function of PKM2 in hepatocellular carcinoma: A review

Zhang,

Liao,

et al. 2023

Medicine

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Hepatocellular carcinoma (HCC) is one of the most malignant tumors with the highest incidence and mortality in the world, causing a serious burden on society. Pyruvate kinase M2 (PKM2) is one of the principal metabolic enzymes involved in glycolysis. Studies have shown that PKM2 is highly expressed in HCC and can be translocated to the nucleus, where it interacts with various transcription factors and proteins such as hypoxia-inducible factor-1α, sterol regulatory element-binding protein 1a, signal transducer and activator of transcription 3, nuclear factor erythroid 2-like 2 and histone H3, exerting non-metabolic enzyme functions to regulate the cell cycle, proliferation, apoptosis, immune escape, migration, and invasion, as well as HCC angiogenesis and tumor microenvironment. This review is focused on the recent progress of PKM2 interacting with various transcription factors and proteins affecting the onset and development of HCC, as well as natural drugs and noncoding RNA impacting diverse biological functions of liver cancer cells by regulating PKM2 non-metabolic enzyme functions, thereby providing valuable directions for the prognosis improvement and molecular targeted therapy of HCC in the future.

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Section: Noncoding Rna Regulates Pkm2 Non-metabolic Enzyme Functionmentioning

confidence: 99%

Section: The Effect Of Regulating Pkm2 Non-metabolic Enzyme Function ...mentioning

confidence: 99%

Non-metabolic enzyme function of PKM2 in hepatocellular carcinoma: A review

Zhang,

Liao,

et al. 2023

Medicine

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Characterization of RBM15 protein binding with long noncoding RNAs

Bose,

Mayes,

Ellis

et al. 2023

Preprint

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Long noncoding ribonucleic acids (lncRNAs) are transcripts greater than 500 nucleotides in length that do not encode for protein. Through their sequences and structures, lncRNAs interact with other nucleic acids and proteins to regulate a variety of biological processes, including gene expression. The rate at which lncRNAs have been identified exceeds our ability to study their structures and functions. Within the last decade, several tens of thousands have been discovered throughout the human genome, yet fewer than 50 have been structurally characterized. In an attempt to better understand and map the vast molecular networks that underlie biological activity, several genome-wide studies have been carried out to study RNA structures, identify their cognate protein binding partners, and map sites of protein binding. Every class of RNA is represented in these studies, including lncRNAs. In this study, we mined this data to investigate the propensity of X-inactivation (XCI) escaping lncRNAs to interact with the RNA binding protein (RBP) RBM15. We find that XCI-escaping lncRNAs are intricately structured and, depending on their localization (cytoplasm, nucleoplasm, chromatin), adopt different structures. Bioinformatic and experimental analyses reveal that U-containing sequences are bound by RNA recognition motifs (RRMs) 2 and 3 of RBM15. Collectively, the mining of data, carried out by graduate students of the New York University Spring 2023 Macromolecular Chemistry course, and the experimental validation of those results, carried out by high school summer interns from traditionally excluded groups, demonstrates i) an efficient way to make use of the genome-wide studies that have been carried out to better understand how lncRNAs function and ii) a way to engage students from a variety of backgrounds in biological research.

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Glycolysis-associated lncRNAs in cancer energy metabolism and immune microenvironment: a magic key

Zhang,

Liu

et al. 2024

Front. Immunol.

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The dependence of tumor cells on glycolysis provides essential energy and raw materials for their survival and growth. Recent research findings have indicated that long chain non-coding RNAs (LncRNAs) have a key regulatory function in the tumor glycolytic pathway and offer new opportunities for cancer therapy. LncRNAs are analogous to a regulatory key during glycolysis. In this paper, we review the mechanisms of LncRNA in the tumor glycolytic pathway and their potential therapeutic strategies, including current alterations in cancer-related energy metabolism with lncRNA mediating the expression of key enzymes, lactate production and transport, and the mechanism of interaction with transcription factors, miRNAs, and other molecules. Studies targeting LncRNA-regulated tumor glycolytic pathways also offer the possibility of developing new therapeutic strategies. By regulating LncRNA expression, the metabolic pathways of tumor cells can be interfered with to inhibit tumor growth and metastasis, thus affecting the immune and drug resistance mechanisms of tumor cells. In addition, lncRNAs have the capacity to function as molecular markers and target therapies, thereby contributing novel strategies and approaches to the field of personalized cancer therapy and prognosis evaluation. In conclusion, LncRNA, as key molecules regulating the tumor glycolysis pathway, reveals a new mechanism of abnormal metabolism in cancer cells. Future research will more thoroughly investigate the specific mechanisms of LncRNA glycolysis regulation and develop corresponding therapeutic strategies, thereby fostering new optimism for the realization of precision medicine.

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LncRNA ZNF674-AS1 Hinders Proliferation and Invasion of Hepatic Carcinoma Cells through the Glycolysis Pathway

Cited by 3 publications

References 36 publications

Non-metabolic enzyme function of PKM2 in hepatocellular carcinoma: A review

Non-metabolic enzyme function of PKM2 in hepatocellular carcinoma: A review

Characterization of RBM15 protein binding with long noncoding RNAs

Glycolysis-associated lncRNAs in cancer energy metabolism and immune microenvironment: a magic key

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