LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma

Ma, Xiangrui; Sui, Sheng; Wu, Jing‐biao; Jiang, Yaping; Gao, Xiaolei; Cen, Xiao; Wu, Jian; Wang, Shasha; Tang, Ya‐Jie; Tang, Yaling; Liang, Xin‐hua

doi:10.18632/oncotarget.14939

Cited by 41 publications

(38 citation statements)

References 47 publications

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“…Ma et al. () observed 132 differentially expressed lncRNAs including HOTAIR, PROM1, CCAT1, and MUC19 in different HPV‐infected states and suggested their role in HPV16 promoting myeloid‐derived suppressor cell recruitment of HNSCC (Ma et al., ).…”

Section: Introductionmentioning

confidence: 99%

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

et al. 2017

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides) responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor suppressor miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and have been also implicated in carcinogenesis. These molecules have been suggested to be promising candidates as diagnostic and prognostic biomarkers and for development of novel therapeutic approaches. In this review, we have summarized recent findings on role of these ncRNAs in HPV-negative (HPV-ve) and HPV-positive (HPV+ve) HNSCC. The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs.

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Section: Introductionmentioning

confidence: 99%

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

et al. 2017

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“…In another study, Ma et al explained the difference in the recruitment of MDSCs seen in human papilloma virus (HPV)-positive head, neck squamous cell carcinoma (HNSCC) and HPV-negative HNSCC by using lncRNA analysis. The results showed significant function and importance of lncRNAs in HPV-associated HNSCC, demonstrating that lncRNA is a possible regulator of MDSCs recruitment in HPV-positive HNSCC ( 128 ). The level of MDSCs in HPV-positive HNSCC was notably more than in normal controls, indicating that infection with HPV can support aggregation of MDSCs.…”

Section: Long Non-coding Rnasmentioning

confidence: 89%

“…HOTAIR, PROM1, CCAT1, and MUC19 mRNA levels, as detected by qRTPCR, which were reversely related to MDSCs of HPV-related HNSCC. Therefore, lncRNAs resembled a modulatory factor in HPV16 supporting MDSC recruitment in HNSCC ( 128 ).…”

Section: Long Non-coding Rnasmentioning

confidence: 99%

MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation

et al. 2020

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Myeloid-derived suppressor cells (MDSCs) constitute an important component in regulating immune responses in several abnormal physiological conditions such as cancer. Recently, novel regulatory tumor MDSC biology modulating mechanisms, including differentiation, expansion and function, were defined. There is growing evidence that miRNAs and long non-coding RNAs (lncRNA) are involved in modulating transcriptional factors to become complex regulatory networks that regulate the MDSCs in the tumor microenvironment. It is possible that aberrant expression of miRNAs and lncRNA contributes to MDSC biological characteristics under pathophysiological conditions. This review provides an overview on miRNAs and lncRNAs epiregulation of MDSCs development and immunosuppressive functions in cancer.

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“…HPV infection results in alterations in the expression of a number of lncRNAs (12), and lncRNAs act as intermediates in HPV-mediated pathogenesis connecting HPV infection and downstream signaling pathways (13). During the development of cervical cancer, numerous lncRNAs display altered expression patterns, and serve different roles to promote or inhibit tumor progression (14,15).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA‑OIS1 inhibits HPV‑positive, but not HPV‑negative cervical squamous cell carcinoma by upregulating MTK‑1

Zhou

Cui

et al. 2019

Oncol Lett

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Long non-coding RNA-oncogene-induced senescence 1 (lncRNA-OIS1) is a novel lncRNA that is involved in oncogene-induced senescence, while its functionality in cervical squamous cell carcinoma is unknown. In the present study, 68 human papillomavirus (HPV)-positive and 22 HPV-negative patients with cervical squamous cell carcinoma were recruited. Additionally, 40 healthy females were employed as healthy controls. Tumor tissues and adjacent healthy tissues were collected from all patients with cervical squamous cell carcinoma, and blood samples were obtained. Expression of OIS1 was detected by reverse transcription-quantitative polymerase chain reaction. Receiver operating characteristic curve analysis was used to evaluate the diagnostic value of OIS1 for cervical squamous cell carcinoma. HPV-positive and HPV-negative cervical squamous cell carcinoma and normal cervical cell lines were used, and the effects of OIS1 or mitogen-activated protein kinase kinase kinase 4, (MTK-1) expression vector transfection on the proliferation of cell lines and MTK-1 expression were detected by CCK-8 assay and western blotting, respectively. It was established that a reduction in OIS1 expression level in tumor tissues was apparent only in HPV-positive patients. Serum levels of OIS1 were lower in HPV-positive patients compared with that in HPV-negative patients and healthy controls, and no significant differences were observed between HPV-negative patients and healthy controls. Serum levels of OIS1 were significantly associated with tumor size, but not distant tumor metastasis. OIS1 expression level was lower in HPV-positive cancer cell lines compared with that in HPV-negative cancer cell lines, while no significant differences were observed between HPV-positive and HPV-negative normal cell lines. OIS1 overexpression inhibited and MTK-1 overexpression promoted the proliferation of HPV-positive, but not HPV-negative cancer or normal cell lines. OIS1 transfection also decreased the expression of MTK-1 in HPV-positive cancer cell lines, but not in any of the other cell lines. Therefore, it was concluded that OIS1 inhibited HPV-positive, but not HPV-negative cervical squamous cell carcinoma by upregulating MTK-1.

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LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma

Cited by 41 publications

References 47 publications

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

MicroRNAs and lncRNAs—A New Layer of Myeloid-Derived Suppressor Cells Regulation

Long non‑coding RNA‑OIS1 inhibits HPV‑positive, but not HPV‑negative cervical squamous cell carcinoma by upregulating MTK‑1

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