LncRNAs LY86-AS1 and VIM-AS1 Distinguish Plasma Cell Leukemia Patients from Multiple Myeloma Patients

Abstract

Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Due to modern genomic techniques, the involvement of lncRNAs in tumorigenesis has been revealed; however, information concerning lncRNA interplay in multiple myeloma (MM) and plasma cell leukemia (PCL) is virtually absent. Herein, we aimed to identify the lncRNAs involved in MM to PCL progression. We investigated representative datasets of MM and PCL patients using next-generation sequencing. In total, 13 deregulated lncRNAs (p < 0.00025) were identified; four of them were chosen for further validation in an independent set of MM and PCL patients by RT-qPCR. The obtained results proved the significant downregulation of lymphocyte antigen antisense RNA 1 (LY86-AS1) and VIM antisense RNA 1 (VIM-AS1) in PCL compared to MM. Importantly, these two lncRNAs could be involved in the progression of MM into PCL; thus, they could serve as promising novel biomarkers of MM progression.

Immunogenic cell death-related long noncoding RNA influences immunotherapy against lung adenocarcinoma

“…Therefore, we hypothesize that AC026355.2, despite being rarely reported, is essential for tumor growth, and further research is necessary to determine its exact function. LY86-AS1 is a lncRNA involved in the progression of multiple myeloma [ 27 ], Alzheimer’s disease [ 28 ], intracerebral hemorrhage [ 29 ], and LUAD [ 30 ]. According to our results, LY86-AS1 expression was downregulated in LUAD cells, and patients with low LY86-AS1 expression had poorer OS than high-LY86-AS1 patients.…”

Genomics of Plasma Cell Leukemia

“…In particular, expression levels of 15 lncRNAs were progressively increased from NPC to PCL patients, while six lncRNAs showed a significant decrease in the transition from NPC and premalignant entities to more aggressive forms. LncRNAs involved in the progression from MM to PCL have recently been explored [39]. A total of 13 dysregulated lncRNAs was detected.…”

Mitophagy-related gene signature for predicting the prognosis of multiple myeloma

“…Beider et al indicated that transient receptor potential vanilloid 1 (TRPV1) contributed to the development of MM by disturbing calcium homeostasis and the bortezomib-induced unfolded protein response [ 9 ]. As autophagic markers, genes encoding proteins such as beclin 1 (BECLIN1) and light chain 3 (LC3) have been shown to improve the prognosis and survival of patients with MM [ 10 , 11 ]. A recent study proposed a prognostic model based on 15 autophagy-related genes that could effectively predict the prognosis of patients with MM [ 12 ].…”