LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

Chen, Zhenzhen; Huang, Lan; Wu, Yahong; Zhai, Wenjie; Zhu, Pingping; Gao, Yanfeng

doi:10.1038/ncomms12598

Cited by 178 publications

(162 citation statements)

References 37 publications

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“…Furthermore, Kaplan-Meier survival analysis and Cox proportional hazards regression analysis verified that lncRNA-AWPPH is not only correlated with poor recurrence-free survival and overall survival, but also an independent prognostic factor for recurrence-free survival and overall survival. Our results demonstrate that lncRNA-AWPPH could serve as a prognostic biomarker for HCC.Some of the aberrantly expressed lncRNAs are potential diver events of tumor initiation and progression, whereas others may be just bystander events accompanying the tumor initiation and progression[39]. Thus, it is important to distinguish the driver events from the bystander events.…”

mentioning

confidence: 88%

Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker

Zhao

Liu

2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

100

107

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Long noncoding RNAs (lncRNAs) have been shown to play important roles in various cancers. However, the clinical significances and biological roles of lncRNAs in hepatocellular carcinoma (HCC) remain largely unknown. In this study, using online-available data sets and quantitative real-time PCR, we identified a novel lncRNA termed lncRNA-AWPPH, which is highly expressed in HCC tissues. Its upregulation is correlated with encapsulation incomplete, microvascular invasion, advanced TNM stage and BCLC stage. Cox proportional hazards regression analysis revealed that high lncRNA-AWPPH expression is an independent prognostic factor for poor recurrence-free and overall survival. Functional experiments showed that overexpression of lncRNA-AWPPH promotes HCC cell proliferation and migration in vitro, and tumor growth and metastasis in vivo. Conversely, depletion of lncRNA-AWPPH has opposite effects on HCC. Mechanistically, lncRNA-AWPPH interacts with YBX1, promotes YBX1-mediated activation of SNAIL1 translation, and upregulates SNAIL1 expression. Furthermore, lncRNA-AWPPH promotes YBX1-mediated activation of PIK3CA transcription, upregulates PIK3CA expression, and activates PI3K/AKT pathway. Depletion of YBX1 abolishes the effects of lncRNA-AWPPH on SNAIL1 and PIK3CA, and also the biological roles of lncRNA-AWPPH on HCC cells. In conclusion, this study identifies a novel lncRNA termed lncRNA-AWPPH which is highly expressed in HCC, indicates poor prognosis of HCC patients, and promotes HCC cell proliferation, migration, and in vivo tumor growth and metastasis via a novel regulatory mechanism of interacting with YBX1.

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mentioning

confidence: 88%

Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker

Zhao

Liu

2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

100

107

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“…Sox4 is an important member of the SoxC (SRY-related high-motility group box) transcription factors family and is the first transcription factor found in the SOX family [28]. Numerous studies have suggested that SOX4 is over expressed in different cancers and correlative with tumor development [29,30]. The regulation effect of Sox4 on EMT is mainly related to TGF-β/Smad pathway, Wnt signaling pathway and its own transcription factor activity [31,32].…”

Section: H19 and Sox4 Are Target Genes Of Mir-130a-3pmentioning

confidence: 99%

H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Yin

Zeng

et al. 2018

Cell Physiol Biochem

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Background/Aims: Glioma is one of the most devasting tumors and confers dismal prognosis. Long noncoding RNAs(lncRNAs) have emerged as important regulators in various tumors including glioma. A classic lncRNA-H19, which is found to be highly expressed in human glioma tissues and cell lines, and is associated with tumor progression thus predicating clinical outcomes in glioma patients. However, the overall biological functions and their mechanism of H19 in glioma are not fully understood. Methods: Firstly, we analyzed H19 alterations in different grades of glioma tissues through an analysis of 5 sequencing datasets and qRT-PCR was performed to confirm the results. Next, we evaluated the effect of H19 on glioma cells migration, invasion and EMT process. Luciferase assays and RIP assays were employed to figure out the correlation of H19 and SOX4. Results: H19 was overexpressed in glioma tissues. Down-regulation of H19 led to the inhibition of migration, invasion and EMT process with a reduction in N-cadherin and Vimentin. H19 and SOX4 are both direct target of miR-130a-3p. H19 could compete with SOX4 via sponging miR-130a-3p. Conclusion: Taken together, these results provide a possible function of H19 as an oncogene in glioma tissues and provide a potential new therapeutic strategy for human glioma.

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“…Depending on the length, ncRNAs could be classified into short or long ncRNAs with an arbitrary size cut-off at 200 bases of length, being the most known (a) the long-ncRNA (lncRNA) and (b) the microRNA (miRNA). lncRNAs function take place by different molecular mechanisms such as interactions with DNA, RNA and proteins and can be classified into oncogenic or tumor suppressive genes [93][94][95][96][97][98] . Besides lncRNAs, miRNAs are endogenous small RNAs molecules with 20-25 bases of length.…”

Section: Circulating Non-coding Rnamentioning

confidence: 99%

Performance of different biomarkers for the management of hepatocellular carcinoma

Rojas¹,

Sánchez‐Torrijos²,

Gil‐Gómez³

et al. 2018

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Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the second cause of cancer related death due to latent liver disease, late diagnosis and non-available therapeutic treatment. Liver biopsy is still the gold standard in order to know the molecular biology of the tumor, its behaviour and invasive characteristics. Conventional diagnosis methods for HCC detection include imaging and serological tests with low sensitivity and specificity. In this review, we focus on the potential utility of certain serum biomarkers and a new approach, "liquid biopsy", in the management of HCC patients.

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LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

Cited by 178 publications

References 37 publications

Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker

Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker

H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma

Performance of different biomarkers for the management of hepatocellular carcinoma

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