Loading and release mechanisms of MOF-5 @ BTA-X (X = -CH3/-NH2/-CO(CH2)6CH3): Experimental and theoretical investigations

Cao, Jiaojiao; Guo, Chengbin; Chen, Zhenyu

doi:10.1016/j.colsurfa.2023.131274

Cited by 10 publications

(2 citation statements)

References 64 publications

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“…The XRD results of the NG con rm that excellent crystallinity of the organic molecule was shown by the strong, high-intensity crystalline peaks in the powder diffraction pattern spectrum of NG [54,55]. The ndings investigated whether NG lling of MOF-5 preserves the original crystal structure of MOF-5.…”

Section: Discussionmentioning

confidence: 84%

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Elbeltagi,

Alharbi,

Aodah

et al. 2024

Preprint

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Tumors are considered dangerous due to their significant global mortality rate, with breast cancer (BC) being a major contributor to this statistic, impacting almost all tumor patients worldwide. Conventional methods for BC treatment, such as special naringin (NG) chemotherapy based on nanotechnology components, have been insufficient, and a new approach has been used to improve drug delivery (DD) to cancer. Herein, developed biocompatible nanoparticles (NPs) comprising NG-loaded zinc metal-organic framework-5 (NG-MOF-5) encapsulated with liponiosomes (LNs) to create NG-MOF-5@LNs. Various biophysical characteristics of free NG, MOF-5, and NG-MOF-5@LNs NPs were studied, including XRD, FTIR, TEM, SEM, zeta potential (ZP), hydrodynamic size, PDI, loading efficiency (LE), encapsulation efficiency (EE), drug release (DR), and drug-release kinetics. TEM images showed that NG-MOF-5@LNs NPs consisted of monodispersed spherical-like particles with average diameters of 122.5 nm (*P < 0.05). The optimized NG-MOF-5@LNs exhibited a particle size (PDI: 139.8 nm) and a ZP (+ 21 mV). The EE and LE for NG-MOF-5@LNs were 89.15% and 14.05%, respectively. Four kinetic models were examined to understand the NG release mechanism at pH 6.9, with the Higuchi model indicating excellent fit (R2 = 0.9988). The MTT cell viability assay demonstrated anti-cancer activity against MCF-7 BC cells, with inhibitory concentrations (IC50) of 231.9, 188.2, and 21.6 µg/mL (*P < 0.05) for MOF-5, NG, and NG-MOF-5@LNs, respectively, indicating an apoptosis effect on MCF-7 cells. NG-MOF-5@LNs is expected to emerge as a novel long-term-release anticancer agent. NG-MOF-5@LNs may represent a superior option for BC therapy compared to conventional NG formulations.

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Section: Discussionmentioning

confidence: 84%

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Elbeltagi,

Alharbi,

Aodah

et al. 2024

Preprint

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show abstract

“…The particle morphologies of the samples, as assessed by a comparison of SEM images of MOF-5, met@MOF-5 and ceph@MOF-5, are displayed in Figure 2. The pristine The PXRD patterns of met@MOF-5 appeared similar to the pristine MOF and showed all characteristic peaks of the pristine MOF-5, indicating that the crystal structure of the MOF after drug loading remained largely unaffected and the presence of the drug molecules did not alter the lattice parameters of the MOF [42,43].…”

Section: Semmentioning

confidence: 91%

Biodegradable Polymer Composites of Metal Organic Framework-5 (MOF-5) for the Efficient and Sustained Delivery of Cephalexin and Metronidazole

Anim,

Mahmoud,

Kelly

et al. 2023

Applied Sciences

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The sustained and controlled delivery of antimicrobial drugs has been largely studied using nanomaterials, like metal organic frameworks (MOFs), and various polymers. However, not much attention has been given to combining MOFs and biodegradable polymers towards the potentially more sustained release of active pharmaceutical ingredients. Herein, we report a comparative study of two widely used antimicrobial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated into biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) composites. Cephalexin and metronidazole were separately loaded into MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL composites. The pristine MOF-5 and the loaded MOFs were thoroughly characterised using Fourier-transformed infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and powder X-ray diffraction (PXRD). Ultraviolet-visible (UV-Vis) spectroscopy studies were carried out to assess the release of the drugs in PBS for up to 72 h, showing a cumulative release of 24.95 wt% and 27.84 wt% for cephalexin and metronidazole, respectively. The antibacterial properties of the pristine MOF, pure drugs, drug-loaded MOFs and the loaded composites were assessed against Gram-positive and Gram-negative bacterial strains, Staphylococcus aureus or Staphylococcus epidermidis and Escherichia coli or Acinetobacter baumanii, respectively. A cephalexin-loaded MOF-5 composite of PCL (PCL-ceph@MOF-5) showed the best efficiency for the controlled release of drugs to inhibit the growth of the bacteria compared to the other composites. This study demonstrates that the combination of MOFs with biodegradable polymers can provide an efficient platform for the sustained release of antimicrobial drugs and can be a promising tool to manage antimicrobial resistance (AMR).

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One-step hydrothermal fabrication of Co-MOFs/LDH superhydrophobic composite coating with corrosion resistance and wear resistance on anodic aluminum oxide

Xiong,

Zhang,

jin

et al. 2024

Applied Surface Science

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Loading and release mechanisms of MOF-5 @ BTA-X (X = -CH3/-NH2/-CO(CH2)6CH3): Experimental and theoretical investigations

Cited by 10 publications

References 64 publications

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Investigation and optimization of naringin-loaded in MOF-5 encapsulated by liponiosomes as smart drug delivery, cytotoxicity, and apoptotic on breast cancer cells

Biodegradable Polymer Composites of Metal Organic Framework-5 (MOF-5) for the Efficient and Sustained Delivery of Cephalexin and Metronidazole

One-step hydrothermal fabrication of Co-MOFs/LDH superhydrophobic composite coating with corrosion resistance and wear resistance on anodic aluminum oxide

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