Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes

Zhang, Changhong; Zhao, Kejia; Hu, Tianyi; Cui, Xiaofeng; Brown, Nathan; Boland, Thomas

doi:10.1016/j.jconrel.2008.07.026

Cited by 54 publications

(41 citation statements)

References 38 publications

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“…Nile Blue A (NBA) 55,56 was chosen as a model-drug to evaluate the dual-stimuli nanogel N30 as a drug delivery vehicle. This molecule presents both low molecular weight and cationic charge, which allows an ionic interaction with the carboxylic groups of the A-Pro-OH monomer.…”

Section: Drug Release Applicationmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N'-methylenebis (acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43°C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43°C, thus confirming the dual stimuli switch.

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Section: Drug Release Applicationmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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“…The biodegradation of material was carried out as per the protocol given by Zhang et al [52]. Degradation of material in biological environment represents one of the important aspects for various biomedical applications.…”

Section: Study Of Enzymatic Degradation Of Sh-hpmc-aamentioning

confidence: 99%

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

Barik

Patnaik²,

Parhi

et al. 2017

Polym. Bull.

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A new pH-responsive carrier matrix was designed from combination of shellac (Sh), hydroxpropylmethylcellulose (HPMC) and acrylic acid (AA). Characterization of materials was done using various advanced instrumentation techniques. The kinetics of thermal decomposition of materials were studied and compared using Coats-Redfern (CR) and Kissinger-Akahira-Sunose (KAS) mathematical models. The Arrhenius equations for thermal decomposition of shellac and chemically modified shellac (Sh-HPMC-AA) were computed to be k = (3.4 9 10 21 ) e -159.9/RT and k = (141.8) e -19.6/RT s -1 , respectively. The pHresponsive characteristics of Sh-HPMC-AA shows 288% swelling ratio. Further, the controlled release of 5-amino salicylic acid (5-ASA) was studied in buffer medium and Fick's diffusion equation was applied for calculation of transport phenomenon. The enzymatic degradation study of Sh-HPMC-AA is also reported.

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“…The swelling ratio is a measure of the ability of hydrogel to imbibe water. Accordingly, as swelling ratio is higher, the mesh size is larger, resulting in a higher degree of release [29]. According to the results of swelling ratio of CM-b-CD hydrogels (Fig.…”

Section: Swelling Ratiosmentioning

confidence: 94%

pH-Dependent release of blue dextran from carboxymethyl-β-cyclodextrin hydrogels

Xia

Kim

2010

Journal of Industrial and Engineering Chemistry

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Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes

Cited by 54 publications

References 38 publications

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Synthesis and characterization of new shellac–hydroxypropylmethylcellulose composite for pharmaceutical applications

pH-Dependent release of blue dextran from carboxymethyl-β-cyclodextrin hydrogels

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