Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation

Kiss, Izabella; Unger, Christine; Nguyen, Chi Huu; Atanasov, Atanas G.; Kramer, Nina; Chatruphonprasert, Waranya; Brenner, Stefan; McKinnon, Ruxandra; Peschel, Andrea; Vasas, Andrea; Lajter, Ildikó; Kain, Renate; Saiko, Philipp; Szekeres, Thomas; Kenner, Lukas; Hassler, Melanie R.; Díaz, Raúl Guinovart; Frisch, Richard; Dirsch, Verena M.; Jäger, Walter; Martin, Rainer de; Bochkov, Valery N.; Paßreiter, Claus M.; Peter-Vörösmarty, Barbara; Mader, Robert M.; Grusch, Michael; Dolznig, Helmut; Kopp, Brigitte; Zupkó, István; Hohmann, Judit; Krupitza, Georg

doi:10.1016/j.canlet.2014.11.019

Cited by 7 publications

(13 citation statements)

References 35 publications

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“…The CCID assay, which measures the size of the cell-free area within the lymphendothelial cell (LEC) monolayer, which forms underneath 12(S)-HETE-secreting MCF-7 spheroids, was performed as described before (Kerjaschki et al 2011;Kiss et al 2015;Madlener et al 2010;Vonach et al 2011). During the experiments, which were short term, we did not observe toxic effects of the tested compounds (monitored by HOPI staining).…”

Section: Circular Chemorepellent Induced Defect (Ccid) Assaymentioning

confidence: 99%

“…SR-786 cells were treated with N. lobata compounds and quantitative RT-PCR performed as described by Kiss et al (2015). The following primers were used for RT-PCR: To analyse qPCR data, the Ct ( Ct) method (Livak and Schmittgen 2001) for relative quantification of gene expression was used.…”

Section: Quantitative Rt-pcrmentioning

confidence: 99%

“…Hoechst 33258 (HO) and propidium iodide (PI) double staining (Sigma-Aldrich, St. Louis, MO, USA) allows the determination of the cell death type, apoptosis or necrosis and was performed as described by Kiss et al (2015).…”

Section: Cell Death Analysis -(Ho/pi Staining)mentioning

confidence: 99%

“…To evaluate mitochondrial/metabolic activity and cytotoxicity, CellTiter-Blue assay (Promega, Madison, WI) was applied and measured by a multi-detection reader at 570 nm (Synergy HT, Bio-Tek Instrument, Winooski, VT, USA) (Kiss et al 2015).…”

Section: Cytotoxicity Metabolic Activity Assaymentioning

confidence: 99%

“…It has recently been shown that the apolar extract of N. lobata and the contained furanoheliangolide sesquiterpene lactone lobatin B inhibited the expression of the fusion onco-protein NPM/ALK (Kiss et al 2015;Unger at al. 2013).…”

Section: Introductionmentioning

confidence: 98%

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The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

et al. 2015

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Section: Circular Chemorepellent Induced Defect (Ccid) Assaymentioning

confidence: 99%

Section: Quantitative Rt-pcrmentioning

confidence: 99%

Section: Cell Death Analysis -(Ho/pi Staining)mentioning

confidence: 99%

Section: Cytotoxicity Metabolic Activity Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

et al. 2015

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Antiproliferative and Cytotoxic Activities

Anesini

Alonso

Martino

2018

Sesquiterpene Lactones

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Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms

et al. 2016

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The activator protein-1 (AP-1) is a dimeric transcription factor composed of proteins belonging to the Jun (c-Jun, JunB and JunD), Fos (c-Fos, FosB, Fra1 and Fra2) and activating transcription factor protein families. AP-1 is involved in various cellular events including differentiation, proliferation, survival and apoptosis. Deregulated expression of AP-1 transcription factors is implicated in the pathogenesis of various lymphomas such as classical Hodgkin lymphomas, anaplastic large cell lymphomas, diffuse large B cell lymphomas and adult T cell leukemia/lymphoma. The main purpose of this review is the analysis of the expression patterns of AP-1 transcription factors in order to gain insight into the histophysiology of lymphoid tissues and the pathology of lymphoid malignancies.

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Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation

Cited by 7 publications

References 35 publications

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

Antiproliferative and Cytotoxic Activities

Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms

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