Lobectomy offers improved survival outcomes relative to segmentectomy for &gt;2 but ≤4 cm non–small cell lung cancer tumors

Peng, Terrance; Wightman, Sean C.; Ding, Li; Lieu, Dustin; Atay, Scott M.; David, Elizabeth A.; Kim, Anthony W.

doi:10.1016/j.xjon.2022.03.002

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…The baseline characteristics are summarized in Table 1 . Among them, five studies were performed in Asia ( 7 , 11 , 12 , 21 , 23 ), and five studies were performed in America and Europe ( 8 – 10 , 22 , 24 ). According to the NOS, 6 studies ( 9 – 12 , 22 , 23 ) were of high quality, and 4 studies ( 7 , 8 , 21 , 24 ) were of medium quality ( Table S3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among them, five studies were performed in Asia ( 7 , 11 , 12 , 21 , 23 ), and five studies were performed in America and Europe ( 8 – 10 , 22 , 24 ). According to the NOS, 6 studies ( 9 – 12 , 22 , 23 ) were of high quality, and 4 studies ( 7 , 8 , 21 , 24 ) were of medium quality ( Table S3 ). The quality of evidence assessed using the GRADE was found to be low to very low for all outcomes ( Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

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Lobectomy versus segmentectomy for stage IA3 (T1cN0M0) non-small cell lung cancer: a meta-analysis and systematic review

Zhang,

Chen,

Lin

et al. 2023

Front. Oncol.

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BackgroundSegmentectomy has been proven to have better survival and perioperative efficacy than lobectomy for non-small cell lung cancer (NSCLC) up to 2 cm. Whether this result is applicable to stage T1cN0M0 NSCLC (2.1 to 3 cm) remains controversial.MethodsWe conducted a comprehensive search across seven databases to identify relevant studies comparing lobectomy and segmentectomy procedures. Our primary focus was on survival indicators (overall survival [OS] and disease-free survival [DFS]), while for secondary outcomes, operative outcomes, hospitalization outcomes, recurrences, and complications were considered.ResultsAfter screening, the final analysis included 10 studies (involving 22113 patients in the lobectomy group and 1627 patients in the segmentectomy group). The lobectomy procedure achieved better OS (hazard ratio [HR]: 1.19 [1.07~1.33]) and DFS (HR: 1.37 [1.10~1.71]), which were proven in all subgroups. The OS rate at 2-5 years and DFS rate at 4-5 years were higher in the lobectomy group. The advantages of OS and DFS in the lobectomy group increased over the survival time. More lymph node dissections, intraoperative blood loss and total complications were found in the lobectomy group. Similar hospital stays, 90-day mortality and conversion thoracotomy were found between the two groups.ConclusionLobectomy appeared to be the better choice for patients with stage T1cN0M0 NSCLC with better survival (OS and DFS). However, the complications needed to be taken seriously.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identification CRD42023445013.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Lobectomy versus segmentectomy for stage IA3 (T1cN0M0) non-small cell lung cancer: a meta-analysis and systematic review

Zhang,

Chen,

Lin

et al. 2023

Front. Oncol.

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“…In this issue of the Journal , Peng and colleagues 5 present a National Cancer Database (NCDB) study that demonstrates that segmentectomy was associated with inferior survival compared with lobectomy in patients with early-stage NSCLC >2 cm but <4 cm. The sample size and national footprint of the NCDB provide a strong platform to begin to tackle this question but are accompanied by selection bias limitations of the NCDB that are now very familiar to the readership.…”

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confidence: 99%