Lobular Breast Cancer Metastasis to the Colon, the Appendix and the Gallbladder

Molina-Barea, Rocío; Rios-Peregrina, Rosa M.; Slim, Mahmoud; Calandre, Elena P.; Hernández-García, María Dolores; Jiménez-Ríos, José Antonio

doi:10.1159/000368430

Cited by 12 publications

(11 citation statements)

References 8 publications

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“…Infiltrating ductal carcinomas is far less likely to metastasize to GI [18][19][20], which is as reported by us. And GI tract involvement occurs more often in the stomach and small bowel when compared to colon and rectum [8].…”

Section: Discussionsupporting

confidence: 84%

Rare Metastases in Colorectum of Infiltrating Ductal Breast Cancer: A Rare Case Report and Review

Zhang

et al. 2020

Preprint

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Background: Breast ductal carcinoma hardly metastasizes to colorectum and the effect of surgery is controversial. We treated one case of patients with breast ductal carcinoma metastasizes to colorectum with surgery and discussed current management experience of breast cancer metastasizing to colorectum by reviewing the literature. Case Presentation: A 37-year-old woman underwent a modified radical mastectomy three years ago for right breast cancer and developed left breast cancer with right breast cancer suspiciously metastasizing to colorectum, left ovary along with oviduct, pancreas, and left acetabulum according to positron emission tomography-computed tomography. Then she had chosen to give up further therapy but was admitted to our department complaining of shapeless feces and mucus pus and blood in stool for 2 years with the process of aggravating symptoms for recent 2 months. Colonoscopy revealed the existence of colorectal carcinoma. She received laparoscopic combined abdominal perineal resection and bilateral ovarian salpingectomy. Postoperative pathology as well as immunohistochemistry supported the origin of primary breast infiltrating ductal cancer. She remained tamoxifen therapy and was alive until she was lost to follow-up.Conclusions: Clinicians must pay attention to any gastro-intestinal symptoms of patients with a medical history of breast cancer since the incipient symptoms of breast cancer metastasis to colorectum are insidious. Definite diagnosis may be difficult even by endoscopy. Surgery should be considered as a therapeutic option and definite diagnostic means combined with immunohistochemistry.

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Section: Discussionsupporting

confidence: 84%

Rare Metastases in Colorectum of Infiltrating Ductal Breast Cancer: A Rare Case Report and Review

Zhang

et al. 2020

Preprint

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“…4 Patients are characterized by poor prognostic profile and few survive longer than 2 years following metastasis. 1,7 This may account for the higher distant metastatic rate in ILCs. 8 Other reasons for metastasis of lobular breast cancer may be explained by E-cadherin which is crucial in the maintenance of epithelial cell polarization.…”

Section: Discussionmentioning

confidence: 99%

“…Lobular breast cancer is rarely known to metastasize to the gastrointestinal tract 1 . A 78‐year‐old with Invasive Lobular carcinoma in remission had partial intestinal obstruction that was discovered from metastasis to the colon.…”

Section: Introductionmentioning

confidence: 99%

A rare case of lobular breast cancer metastasizing to large bowel

Yanagisawa

Krishnan²,

Fernandez³

2021

Clinical Case Reports

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“…ILC accounts for 10% of all breast cancers, and is the second most common breast carcinoma 1,3 . The incidence is increasing in postmenopausal women, possibly secondary to the use of hormone replacement therapy in this age group 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Due to high expression of steroid hormone receptors in lobular breast cancer, adjuvant endocrine treatment is the preferred treatment for ILC 7 . Patients are characterised by poor prognostic profile and few survive longer than two years following metastasis 1,8 . The reasons for this mechanism of spread are unclear however may possibly include the histopathology of ILC.…”

Section: Discussionmentioning

confidence: 99%