Lobular carcinoma of the male breast associated with the use of cimetidine

Miguel, P. San; Sancho, M.; Enriquez, Jose Luis; Fernandez, J. M. Ramos; González-Palacios, Fernando

doi:10.1007/bf01324811

Cited by 16 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results of several studies suggest that men with higher educational and socioeconomic status, without children, exposed to electromagnetic fields, high temperatures or polycyclic aromatic hydrocarbons are more prone to develop breast cancer [5,[16][17][18]. It has been hypothesized that there is a relationship between male breast cancer and administration of serotonin reuptake inhibitors [19]. Another factor postulated in the pathogenesis of breast carcinoma in men is an excessive exposition to estrogens (of endogenous and exogenous origin) [20].…”

Section: Discussionmentioning

confidence: 98%

Breast cancer and long-term hormonal treatment of male hypogonadism

Mędraś

Filus

Jóźków

et al. 2006

Breast Cancer Res Treat

View full text Add to dashboard Cite

Breast cancer in men is rare and its etiology is multifactorial. Androgens may promote the development of breast carcinoma in men though data on the subject is scarce. We observed 45 men with hypergonadotropic hypogonadism (aged 18-57) who received 250 mg of testosterone esters (Omnadren 250, Jelfa, Poland) every 3-4 weeks for 5-26 years. Seventeen of them were treated for more than 10 years. During the observation period breast cancer was diagnosed in 2 subjects (11% of the followed men). In one case it occurred after 11 years and in the other after 15 years of the therapy. We point to a possible association between long-term androgen replacement and a risk of breast cancer in men.

show abstract

Section: Discussionmentioning

confidence: 98%

Breast cancer and long-term hormonal treatment of male hypogonadism

Mędraś

Filus

Jóźków

et al. 2006

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…Tothebestofourknowledge,thisisthe9thcaseoflobular carcinoma in a male patient to be reported in the English literature (table 1) [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Long-term estrogen exposure, gynecomastia,chronicuseofdrugs,endocrinedisorders,and long-term exposure to radiation or electromagnetic fields havebeenconsideredaspredisposingfactorsforbreastcancerinmen [6,7,25].Noneofthoseriskfactorswereapparent inthepresentcase.…”

Section: Discussionmentioning

confidence: 99%

“…Long-term estrogen exposure, gynecomastia,chronicuseofdrugs,endocrinedisorders,and long-term exposure to radiation or electromagnetic fields havebeenconsideredaspredisposingfactorsforbreastcancerinmen [6,7,25].Noneofthoseriskfactorswereapparent inthepresentcase.…”

Section: Discussionmentioning

confidence: 99%

Lobular Breast Cancer in Men: Case Report and Review of the Literature

Mariolis‐Sapsakos

Theodoropoulos²,

Flessas³

et al. 2010

Oncol Res Treat

View full text Add to dashboard Cite

Background: Lobular breast cancer in men is an extremely infrequent occurrence due to the lack of lobules and acini in the male breast. Such a rare case is described here. Case Report: A 74-year-old patient presented with a sizeable lesion in the right breast, which proved to be a lobular carcinoma. Genetic studies excluded Klinefelter’s syndrome, though revealing an interesting genetic multiformity feature. This case represented a lobular carcinoma in a genotypically male patient under no exogenous or endogenous estrogenic influence. Conclusions: The increasing number of male lobular breast cancer cases should be explored more extensively with particular emphasis placed on causally related genetic and hormonal factors.

show abstract

“…Numerous etiologies have been elucidated, such as genetic mutations, especially BRCA2, and conditions associated with an imbalance between estrogen and testosterone. Certain medications, such as cimetidine [9,10], are hypothesized to increase the risk for male breast cancer via an estrogenic mechanism. Testicular infection, injury, or maldescent resulting in a relative deficiency of testosterone have been proposed as possible predisposing factors [11].…”

Section: Discussionmentioning

confidence: 99%

Invasive Lobular Carcinoma of the Male Breast: A Rare Histology in an Uncommon Disease

Briest

Vang²,

Terrell

et al. 2009

Breast Care

View full text Add to dashboard Cite

Background: Breast cancer in men is an uncommon disease. Nearly all cases of male breast cancer originate in the terminal ductulolobular unit, with exceedingly rare reports of lobular carcinoma in men. Invasive lobular cancer is found in no more than 1–2% of male breast cancer cases. Most of what is known about this disease is in the form of approximately 30 case reports in the literature. Case Report: We report the case of a 52-year-old man who presented at our institution with a lump in his left breast. Ultrasound-guided biopsy revealed an invasive lobular cancer. The rare histological type was confirmed by the result of the histological examination of the mastectomy specimen. The treatment was completed by dose dense chemotherapy, radiation, and endocrine therapy. Conclusion: Even though lobular structures are quite infrequent in the normal male, sporadic cases of invasive lobular breast cancer have been described. A short overview will be given in this case report.

show abstract

Lobular carcinoma of the male breast associated with the use of cimetidine

Cited by 16 publications

References 21 publications

Breast cancer and long-term hormonal treatment of male hypogonadism

Breast cancer and long-term hormonal treatment of male hypogonadism

Lobular Breast Cancer in Men: Case Report and Review of the Literature

Invasive Lobular Carcinoma of the Male Breast: A Rare Histology in an Uncommon Disease

Contact Info

Product

Resources

About