Local analgesic efficacy of tramadol following intraplantar injection

Mert, Tufan; Güneş, Yılmaz; Günay, İsmail

doi:10.1016/j.ejphar.2006.11.055

Cited by 42 publications

(43 citation statements)

References 22 publications

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“…It has been proposed that tramadol has a lidocaine-like mechanism of action which involves voltage dependent sodium channels causing axonal blockade [2,3,13]. Altunkaya et al [1] have shown that subcutaneous tramadol in minor surgery has a lidocaine-like effect in their study which was conducted on forty patients divided into two groups.…”

Section: Discussionmentioning

confidence: 99%

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The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Ekmekçi

Beriat

Bengisun

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Tramadol is a centrally acting opioid which is effective for moderate-severe pain and is being used for various acute and chronic pain scenarios. The primary endpoint of this controlled, randomized double blind study was to evaluate the effect of submucosal tramadol on VAS scores after septoplasty operations and secondary endpoint was to investigate the effects on total opioid and additional analgesic consumption and patient satisfaction. 60 patients scheduled for septoplasty under general anaesthesia were enrolled. In Group T, at the end of surgery following hemostasis, 2 mg/kg tramadol was applied as submucosal infiltration to both surgical sites, 2 ml (total 4 ml), by the surgeon. In Group P, at the end of surgery following hemostasis, 2 ml isotonic solution (total 4 ml) was applied as submucosal infiltration to both surgical sites by the surgeon. Total opioid consumption, VAS scores, patient satisfaction was evaluated at the end of 24 h VAS values were higher in Group P on the first and second postoperative hours. Patient controlled analgesia demand and delivery values were higher in Group P on the postoperative 1, 2, 4, 6, 12 and 24th hours. Patient satisfaction was higher and opioid consumption was lower in Group T compared to Group P. There was no difference in additional analgesic consumption between two groups. The results show that patients receiving tramadol had lower VAS scores compared with the placebo groups postoperatively.

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Section: Discussionmentioning

confidence: 99%

“…Its weak local anaesthetic effect on peripheral nerves due to the blockage of voltage dependent Na channels has been shown in various studies [2,3]. Following septoplasty operations facial pain due to excision of the cartilage causing the septal deviation and sutures or tampons placed for stabilization is prominent.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Ekmekçi

Beriat

Bengisun

et al. 2012

Indian J Otolaryngol Head Neck Surg

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“…Local anesthesia by tramadol in amphibians and mammals is presumably produced by blockade of sodium channels. 1,2,10 Glutamate, the primary excitatory amino acid neurotransmitter, is released along with other pain mediators in response to tissue damage. 9 Formalin-induced pain behaviour is linked to local glutamate release and is blocked by tramadol.…”

Section: Résumémentioning

confidence: 99%

“…20 Other possible mechanisms of local anesthetic action distinct from sodium channel blockade are unlikely, since tramadol has no effects on inhibitory glycine or gammaaminobutyric acid (GABA) receptors at clinically relevant concentrations. 7 Primary activity through opioid action is unlikely, since direct application of peripheral intraplantar naloxone does not reverse tramadol's effect on reducing heat-induced nociception, 10 and naloxone does not reverse tramadol's ability to block the licking response to formalin in the paw. 20 Thus, it is likely that tramadol produces its analgesic effects in the tail-flick test by blockade of sodium channels.…”

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confidence: 99%

“…There is evidence that tramadol produces local anesthesia in amphibians and mammals 1,10 via blockade of sodium channels. 2 Regarding the possible activity of glutamate receptor antagonists in local anesthetic assays, preliminary studies in our laboratory have shown that a glutamate receptor antagonist did not produce nerve conduction block when administered in the tail at a concentration of 1 mM (data not shown).…”

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confidence: 99%

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Effects of local tramadol administration on peripheral glutamate-induced nociceptive behaviour in mice

Wang

Chung

Whitehead

et al. 2010

Can J Anesth/J Can Anesth

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Purpose The use of peripheral tramadol to block pain has been advocated. However, since its actions in the periphery have not been elucidated fully, we tested the hypothesis that peripheral tramadol blocks peripheral glutamate-induced nociceptive behaviour in mice. Methods First, we compared the duration of paw licking after intraplantar (ipl.) glutamate administration, with and without tramadol, using a randomized blinded controlled design. Next, we established the half maximal effective concentrations (EC 50s ) for local tramadol and reference compound lidocaine in the hot water tail-flick latency test and the glutamate-induced paw allodynia assay. Results Tramadol reduced glutamate-induced paw licking from 33 ± 12 sec to 4 ± 4 sec (mean ± SD; t test, P \ 0.05; n = 6 per group). The tramadol and lidocaine EC 50 nerve conduction blocks in the tail did not differ significantly (84 ± 24 mM vs 69 ± 5 mM, respectively).Although tramadol reduced glutamate-induced allodynia (EC 50 , 46 ± 13 mM), lidocaine was more potent (EC 50 , 13 ± 5 mM; Dixon's up-and-down method; P \ 0.05). Tramadol was 2.5 times as effective at blocking nerve conduction in the tail compared with allodynia in the paw. Conclusions Local tramadol administration blocked nociceptive behaviour in mice induced by peripheral glutamate. Compared with lidocaine, the relative potency of tramadol was lower for blocking glutamate-induced allodynia than for sensory nerve conduction blockade, suggesting the activation of a pronociceptive receptor system in the periphery. RésuméObjectif L'utilisation de tramadol pe´riphe´rique a e´teṕ ropose´e pour bloquer la douleur. Cependant, comme nous ne connaissons pas pleinement ses actions sur les nerfs pe´riphe´riques, nous avons e´mis l'hypothe`se que le tramadol pe´riphe´rique bloquait les comportements nociceptifs provoque´s par le glutamate pe´riphe´rique chez la souris. Méthode Nous avons d'abord compare´la dure´e du le´chage de la patte apre`s une administration intraplantaire (ipl.) de glutamate, avec ou sans tramadol, en utilisant une me´thode contrôle´e randomise´e en aveugle. Ensuite, nous avons de´termine´les concentrations efficaces moyennes (CE 50 ) pour le tramadol administre´localement et un compose´de lidocaı¨ne comme re´fe´rence a`l'aide du test de latence du retrait de la queue et du test d'allodynie de la patte provoque´e par le glutamate. Résultats Le tramadol a re´duit le le´chage de patte provoque´par le glutamate de 33 ± 12 sec a`4 ± 4 sec (moyenne ± ET; test t, P \ 0,05; n = 6 par groupe). Les CE 50 pour le bloc de conduction nerveuse re´alise´avec le

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Neurobiological effects of pulsed magnetic field on diabetes‐induced neuropathy

Mert

Günay

Öcal

2009

Bioelectromagnetics

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In the clinic, although several pharmacological agents or surgical procedures are used to treat diabetes and diabetes-induced neuropathic pain, their success has been limited. Therefore, development of different alternatives in treatments is very important. The purpose of this study was to determine the efficacy of pulsed magnetic field (PMF) in improving signs and symptoms of diabetic neuropathy. In this study, the effects of PMF treatment were investigated in Streptozotocin (STZ)-induced acute and chronic diabetic rats by measuring the thermal latencies, mechanical thresholds, whole blood glucose levels and body weights. After STZ administration to rats, blood glucose level elevated and body weight decreased. Although PMF treatment did not affect changes in body weight, the blood glucose levels of PMF-treated diabetic rats exhibited a decrease during the treatments. Diabetic animals displayed marked decrease in mechanical thresholds and thermal latencies. While treatment of PMF partially restored the mechanical thresholds and thermal latency in acute diabetic rats, PMF caused a corrective effect on only mechanical threshold of chronic diabetic rats. These results suggested that treatment of PMF can potentially ameliorate the painful symptoms of diabetes, such as hyperalgesia and allodynia, by partially preventing the hyperglycemia.

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Local analgesic efficacy of tramadol following intraplantar injection

Cited by 42 publications

References 22 publications

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

The Efficacy of Submucosal Tramadol in the Postoperative Treatment of Pain Following Septoplasty Operations

Effects of local tramadol administration on peripheral glutamate-induced nociceptive behaviour in mice

Neurobiological effects of pulsed magnetic field on diabetes‐induced neuropathy

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