Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT

Multimodal Assessments of Drusenoid Pigment Epithelial Detachments in the Age-Related Eye Disease Study 2 Ancillary Spectral-Domain Optical Coherence Tomography Study Cohort

“…Previous A2A studies identified HRF as an independent risk factor for progression to GA. [4][5][6] Hyperreflective foci can represent anteriorly migrated RPE cells or correlate with lipid-filled cells on histologic analysis 15,16 and generally correspond to macular hyperpigmentation on CFP. 17 We detected HRF overlying the highest point on the DPED during at least one time point before neovascularization or collapse.…”

“…8 For each eye, 6.7 × 6.7 mm SD-OCT volume scans were collected, with each B-scan consisting of 1,000 A-scans and with 67 µ m spacing between each B-scan. The scans were analyzed as previously described by the Duke Reading Center 4,6,8 and for additional measures used in this analysis using 3D Slicer version 4.1 (www.slicer.org). 11…”

“…The AREDS2 Ancillary SD-OCT (A2A) study enrolled AREDS2 participants from four study sites to study disease characteristics with this imaging modality. Previous A2A analyses have identified hyperreflective foci (HRF) and RPE atrophy as factors conferring risk of progression to GA. 4–6…”

“…The AREDS2 Ancillary SD-OCT (A2A) study enrolled AREDS2 participants from four study sites to study disease characteristics with this imaging modality. Previous A2A analyses have identified hyperreflective foci (HRF) and RPE atrophy as factors conferring risk of progression to GA. [4][5][6] In this study, we characterize DPEDs from participants in the A2A cohort with multimodal imaging using reading center-graded CFPs, fundus autofluorescence (FAF) images, and SD-OCTs. The primary goal of this study was to identify OCT features influencing DPED progression and quantify the rate of progression of eyes with DPEDs to late AMD.…”

Three-Dimensional Quantification of Intraretinal Cystoid Spaces Associated With Full-Thickness Macular Hole

“…28 Similar to the loss of intraretinal cystoid spaces over time associated with worsening geographic atrophy in age-related macular degeneration, loss of intraretinal cystoid spaces in more chronic macular holes likely indicates greater tissue atrophy and degeneration. 29 Eyes included in this study had different surgical procedures, such as 25-gauge and 27-gauge system, different types of gas tamponade, and a Brilliant Blue contrast dye was used. 30 It is unknown if these surgical techniques could have affected visual acuity and we have not accounted for it.…”