“…In the RCTs in which NRT was compared to a sham procedure (Kovacs et al 1993, Kovacs et al 1997), adverse events included transient cutaneous discomfort (itching, irritation and redness) after insertion of the surgical staples in 4% to 13% of cases (7% to 11% in the sham group), and limited dermal infection in 0% to 2% of cases (0% to 3% in the sham group). Dermal infection was successfully treated with an antibiotic cream in less than 48 hours in all cases, and none of the patients required extraction of the staples before they were planned to be removed , Kovacs et al 1997.…”