Local and systemic neutrophilic inflammation in patients with lung cancer and chronic obstructive pulmonary disease

Vagulienė, Neringa; Žemaitis, Marius; Lavinskienė, Simona; Miliauskas, Skaidrius; Sakalauskas, Raimundas

doi:10.1186/1471-2172-14-36

Cited by 65 publications

(57 citation statements)

References 37 publications

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“…By taking part in the release and activation of TGF-β 1 , NE affects the development of lung tissue fibrosis. 29,30 In our study, there was a significant negative correlation between the thickness of the L 1 and NE concentrations in BALF. This may suggest that NE is responsible not only for the damage of lung tissue, but also for destruction of some connective tissue components of the bronchial wall.…”

Section: Immune Mediators In Bronchoalveolar Lavage Fluidsupporting

confidence: 52%

Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease

Górka¹,

Soja²,

Jakieła³

et al. 2016

Polish Archives of Internal Medicine

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KEY WORDSchronic obstructive pulmonary disease, computed tomography, emphysema score, endobronchial ultrasound, markers of remodelling ABSTRACT INTRODUCTION Airway remodeling plays an important role in the development of chronic obstructive pulmonary disease (COPD). Imaging methods, such as computed tomography (CT) and endobronchial ultrasound (EBUS), may be useful in the assessment of structural alterations in the lungs.OBJECTIVES The aim of this study was to evaluate a relationship between the severity of emphysema assessed by chest CT, the thickness of bronchial wall layers measured by EBUS, and the markers of remodeling in bronchoalveolar lavage fluid (BALF) in patients with COPD. PATIENTS AND METHODSThe study included 33 patients with COPD who underwent pulmonary function tests, emphysema score assessment by chest CT, as well as bronchofiberoscopy with EBUS in order to measure the total bronchial wall thickness and, separately, layers L 1 , L 2 , and L 3-5 . Selected remodeling (matrix metalloproteinase 9 [MMP-9], tissue inhibitor of metalloproteinase 1, transforming growth factor β 1 [TGF-β 1 ]) and inflammatory markers (neutrophil elastase, eosinophil cationic protein) were measured in BALF samples using an enzyme-linked immunosorbent assay.RESULTS MMP-9 levels in BALF were significantly higher in patients with very severe bronchial obstruction than in those with moderate and mild bronchial obstruction (P = 0.02), and showed a negative correlation with forced expiratory volume in 1 second (r = -0.538, P = 0.002). The thickness of L 1 and L 2 , which histologically correspond to the mucosa, submucosa, and smooth muscle, demonstrated a positive correlation with TGF-β 1 levels in BALF (r = 0.366, P = 0.046 and r = 0.425, P = 0.02) and the thickness of L 1 showed a negative association with neutrophil elastase levels (r = -0.508, P = 0.004). There was no significant correlation between the analyzed markers in BALF and the emphysema score. CONCLUSIONS Significant correlations of TGF-β 1 and elastase with the thickness of bronchial wall layers, and of MMP-9 with the severity of obstruction, may suggest the involvement of these markers in airway remodeling in patients with COPD.

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Section: Immune Mediators In Bronchoalveolar Lavage Fluidsupporting

confidence: 52%

Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease

Górka¹,

Soja²,

Jakieła³

et al. 2016

Polish Archives of Internal Medicine

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“…Another hypothesis supports the proposition that an enhanced expression of granulocyte-macrophage colony-stimulating factor and IL-6 in COPD plays an important role, as these mediators stimulate neutrophils release from the bone marrow causing an increased neutrophil amount in the peripheral blood [7], [8] . Systemic hypoxia due to progression of COPD has been suggested as a possibility [2] .…”

Section: Introductionsupporting

confidence: 61%

Evaluation of Circulating Protein Biomarkers of Inflammation in COPD

Jaswal¹

2017

jmscr

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“…VAGULIENE et al [46] compared NLR values between 139 patients with lung cancer, 55 with lung cancer and stable COPD, 40 with stable COPD and 33 healthy individuals. The NLR was significantly higher in lung cancer patients with COPD (2.92 (0.93-13.42)) or without COPD (3.08 (1.18-8.84)) when compared to non-cancer patients with COPD (2.35 (1.13-4.25)) or healthy individuals (1.86 (1.16-3.21)).…”

Section: Nlr In Patients With Copd and Other Comorbiditiesmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

et al. 2018

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Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

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Local and systemic neutrophilic inflammation in patients with lung cancer and chronic obstructive pulmonary disease

Cited by 65 publications

References 37 publications

Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease

Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease

Evaluation of Circulating Protein Biomarkers of Inflammation in COPD

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

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