Local anesthetic lidocaine delivery system: chitosan and hyaluronic acid-modified layer-by-layer lipid nanoparticles

Abstract

Context: Transdermal local anesthesia is one of the most applied strategies to avoid systemic adverse effects; there is an appealing need for a prolonged local anesthetic that would provide better bioavailability and longer pain relief with a single administration. Objective: Layer-by-layer (LBL) technique was used in this study to explore a nanosized drug delivery system for local anesthetic therapy. Materials and methods: LBL-coated lidocaine-loaded nanostructured lipid nanoparticles (LBL-LA/ NLCs) were prepared and characterized in terms of particle size (PS), zeta potential, drug encapsulation efficiency (EE), in vitro skin permeation and in vivo local anesthetic studies. Results: Evaluation of the in vitro skin permeation and in vivo anesthesia effect illustrated that LBL-LA/NLCs can enhance and prolong the anesthetic effect of LA. Discussion and conclusion: LBL-LA/NLCs could function as a promising drug delivery strategy for overcoming the barrier function of the skin and could deliver anesthetic through the skin with sustained release behavior for local anesthetic therapy.

Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale

“…Hyaluronate chitosan multilayer liposomes (containing 10 alternating layers) with 528 nm particle size exhibited an enhanced transdermal delivery than uncoated unilamellar liposomes (~100 nm) (Jeon et al, 2015). Similarly, multilayered nanostructured lipid nanoparticles coated with hyaluronic acid and chitosan (181 nm) showed a two-fold larger flux across rat skin compared to uncoated nanoparticles (Zhang et al, 2016). In contrast, other authors support that multilamellar and small unilamellar liposomes possess similar ability to penetrate into the SC and viable skin (Lymberopoulos, 2017).…”

Dexmedetomidine and levobupivacaine co-loaded, transcriptional transactivator peptide modified nanostructured lipid carriers or lipid–polymer hybrid nanoparticles, which performed better for local anesthetic therapy?

“…In vitro skin permeation behaviors of NLCs and LPNs were examined using the Franz diffusion method (Zhang et al., 2016 ). The skins from the abdominal surface of rats (fur, adherent fat, and subcutaneous tissues were removed) were mounted on the Franz diffusion cells with a surface area of 0.9 cm 2 and a receptor volume of 5 mL.…”

Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy

“…HA–CH–IRN/5-FU NPs ( Figure 1A ) was fabricated by adding HA solution drop by drop into the CH–IRN/5-FU NP suspensions. 30 The obtained CH–IRN/5-FU NP and HA–CH–IRN/5-FU NP suspensions were collected by centrifugation at 10,000 rpm for 15 min, resuspended in Milli-Q water, washed three times and filtered through a 0.45 μm membrane. The obtained NPs were stored at 2°C–8°C.…”