Local Cerebral Blood Flow and Oxygen Consumption in Evolving Irreversible Ischemic Infarction

Baron, J. C.; Rougemont, D; Lebrun-Grandié, Philippe; Bousser, Marie‐Germaine; Ea, Cabanis; Bories, J; Comar, D.; Castaigne, P

doi:10.1007/978-3-642-95428-3_15

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…If CBF falls as a result of reduced cerebral perfusion pressure, CMR02 is initially maintained by a compensatory elevation of OEF. PET studies of patients with isch emic stroke have found elevated OEF in the terri tory of the infarct in 80-100% of patients studied within � 12 h of onset (Baron et al, 1983;Wise et al, 1983;Correia et al, 1989). Later in the time course of the infarct, a fall in the OEF is seen (Baron et al, 1983;Wise et al, 1983).…”

Section: Effects Of Vasospasmmentioning

confidence: 99%

“…PET studies of patients with isch emic stroke have found elevated OEF in the terri tory of the infarct in 80-100% of patients studied within � 12 h of onset (Baron et al, 1983;Wise et al, 1983;Correia et al, 1989). Later in the time course of the infarct, a fall in the OEF is seen (Baron et al, 1983;Wise et al, 1983). Thus, studies of patients with cerebral ischemia or infarction due to vasospasm might or might not find elevated OEF in affected territories, depending on when in this time course their patients were studied.…”

Section: Effects Of Vasospasmmentioning

confidence: 99%

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Cerebral Oxygen Metabolism after Aneurysmal Subarachnoid Hemorrhage

Carpenter

Grubb

Tempel

1991

J Cereb Blood Flow Metab

132

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Previous studies of cerebral oxygen metabolism and extraction in patients with subarachnoid hemorrhage (SAH) have yielded conflicting results. We used positron emission tomography (PET) to measure the regional cerebral metabolic rate for oxygen (rCMRO2), oxygen extraction fraction (rOEF), and cerebral blood flow (rCBF) 16 times in 11 patients with aneurysmal SAH. All studies were performed preoperatively; no patient had hydrocephalus or intracerebral hematoma on brain CT. Eight patients with no arteriographic vasospasm who were studied on days 1-4 post-SAH had a significant 25% reduction in global CMRO2 compared to age-matched controls, and no significant change in global OEF, suggesting a primary reduction in CMRO2 caused by SAH. Four patients studied seven times during arteriographic vasospasm had significantly increased rOEF with unchanged CMRO2 in arterial territories affected by arteriographic vasospasm compared to territories without vasospasm, indicative of cerebral ischemia without infarction. No brain regions studied with PET were infarcted on follow-up CT. We conclude that the initial aneurysm rupture produces a primary reduction in CMRO2, and that subsequent vasospasm causes ischemia.

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Section: Effects Of Vasospasmmentioning

confidence: 99%

Section: Effects Of Vasospasmmentioning

confidence: 99%

Cerebral Oxygen Metabolism after Aneurysmal Subarachnoid Hemorrhage

Carpenter

Grubb

Tempel

1991

J Cereb Blood Flow Metab

132

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“…Early studies utilizing positron emission tomography (PET) revealed that CBF thresholds for brain function and tissue death were similar to those found in primates stroke models 12–14 . Moreover, a unique pattern of hemodynamic and metabolic change emerged during early phases of ischemia: reduced CBF associated with increased oxygen extraction fraction (OEF, the fraction of oxygen extracted from arterial blood) with preserved oxygen consumption (CMRO 2 ).…”

Section: Imaging the Ischemic Penumbramentioning

confidence: 84%

Defining the Ischemic Penumbra Using Hyperacute Neuroimaging: Deriving Quantitative Ischemic Thresholds

Ford

et al. 2012

Transl. Stroke Res.

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Despite three decades of promise, a neuro-imaging biomarker capable of delineating the ischemic penumbra is yet to be definitively demonstrated. Much progress has been made, especially with MR imaging. However, in order to rigorously define an imaging biomarker of the ischemic penumbra, carefully designed studies which can derive ischemic thresholds using quantitative imaging parameters may be required. Two thresholds are of interest: one which distinguishes the ischemic core from penumbra, and another which distinguishes the penumbra from benign oligemia. In this review, we discuss one possible approach to define these thresholds by following tissue fate in the presence or absence of early reperfusion.

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Positronenemissions- und Kernspinresonanztomographie

Heiss¹

1985

Hirnorganische Psychosyndrome Im Alter II

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Local Cerebral Blood Flow and Oxygen Consumption in Evolving Irreversible Ischemic Infarction

Cited by 8 publications

References 15 publications

Cerebral Oxygen Metabolism after Aneurysmal Subarachnoid Hemorrhage

Cerebral Oxygen Metabolism after Aneurysmal Subarachnoid Hemorrhage

Defining the Ischemic Penumbra Using Hyperacute Neuroimaging: Deriving Quantitative Ischemic Thresholds

Positronenemissions- und Kernspinresonanztomographie

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