Local Delivery of Metronidazole-loaded N-Trimethyl Quaternary Ammonium
Chitosan Nanoparticles for Periodontitis Treatment

Garg, Kritika; Tirgar, Pravin

doi:10.2174/1574885517666220331145439

Cited by 3 publications

References 35 publications

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Green Nanomaterials Zinc Oxide and Chitosan for Antimicrobial Activity Against Oral Pathogens

Rajeshkumar,

Pavithra,

Tharani

et al. 2024

Smart Nanomaterials for Infectious Diseases

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Green nanomaterials that are eco-friendly and biocompatible are ideal for use in the medical field, including dentistry. Nanomaterials have attracted attention in recent years with regard to antimicrobial activity against oral pathogens. Examples are zinc oxide (ZnO) and chitosan, which were found to exhibit antimicrobial activity against oral pathogens and were also useful in the treatment of periodontal diseases. Zinc oxide and chitosan have been shown to be promising alternatives to traditional antimicrobial agents, as they are effective against oral pathogens and were found to have a low toxicity profile. Many nanomaterials and nanocomposites are used in the field of dentistry. In dentistry, nanoparticles are utilized to develop regenerative therapies for oral and dental tissue. For instance, calcium phosphate nanoparticles have been utilized to develop dental implant materials that can promote the growth of new bone tissue. This helps to improve the success rate of dental implants and reduce the risk of implant failure. This chapter gives an insight into the knowledge of oral pathogens, general nanomaterials, nanoparticles, and nanocomposites and their applications in dentistry, especially in endodontics, orthodontics, and periodontics, green synthesis of zinc oxide nanoparticles, antimicrobial activity of zinc oxide and its application in dentistry, and preparation and characterization of chitosan and its antimicrobial activity against oral pathogens.

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Green Nanomaterials Zinc Oxide and Chitosan for Antimicrobial Activity Against Oral Pathogens

Rajeshkumar,

Pavithra,

Tharani

et al. 2024

Smart Nanomaterials for Infectious Diseases

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Assessment of Effect of Intra-pocket Delivery of Metronidazole Loaded NTrimethyl Quaternary Ammonium Chitosan Nanoparticles in Treatment of Periodontal Disease

Garg

Tirgar

2023

CDTH

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Background: Conventional drugs like metronidazole for periodontitis has shown several drawbacks. So based on in-vitro and acute toxicity study of metronidazole loaded n-trimethyl quaternary ammonium chitosan nanoparticles (NTMET NPs), animal studies was carried out to proof enhancement of activities over periodontitis. Objectives: To assess the effect of nanoparticles through an intra-pocket drug delivery on body weight, food consumption, clinical signs, gingival index, tooth mobility, inflammatory changes in periodontal tissues, and serum analysis that leads into gingival damage, connective tissues and alveolar bone resorption. Method: P. gingivalis and ligature induced periodontitis model was used to evaluate the effect of drug in rats. Results: periodontitis was successfully induced by using P. gingivalis and ligature induced periodontitis model in rats. It reflect elevated gingival index, tooth mobility, inflammatory changes in tissues, IL-6, TNF- ɑ, and IL -1β when compared to control group and NTMET NPs treated groups. It was also observed that the damage caused to gingival tissues and resorption of alveolar bone was improved by using NTMET NPs. Conclusion: Based on present findings, we can conclude that NTMET NPs at a dose of 1.8 & 3.6 mg/ml has significant action on periodontal tissues and was able to reverse the effect of P. gingivalis as well as gingival damage and tooth mobility in rats at an administered dose, which are comparable to the IC50 value of a drug. The findings of the current study provide scientific preclinical data to support its clinical use for periodontitis via intra pocket drug delivery route.

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Chitosan, chitosan derivatives, and chitosan-based nanocomposites: eco-friendly materials for advanced applications (a review)

El-Araby,

Janati,

Ullah

et al. 2024

Front. Chem.

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For many years, chitosan has been widely regarded as a promising eco-friendly polymer thanks to its renewability, biocompatibility, biodegradability, non-toxicity, and ease of modification, giving it enormous potential for future development. As a cationic polysaccharide, chitosan exhibits specific physicochemical, biological, and mechanical properties that depend on factors such as its molecular weight and degree of deacetylation. Recently, there has been renewed interest surrounding chitosan derivatives and chitosan-based nanocomposites. This heightened attention is driven by the pursuit of enhancing efficiency and expanding the spectrum of chitosan applications. Chitosan’s adaptability and unique properties make it a game-changer, promising significant contributions to industries ranging from healthcare to environmental remediation. This review presents an up-to-date overview of chitosan production sources and extraction methods, focusing on chitosan’s physicochemical properties, including molecular weight, degree of deacetylation and solubility, as well as its antibacterial, antifungal and antioxidant activities. In addition, we highlight the advantages of chitosan derivatives and biopolymer modification methods, with recent advances in the preparation of chitosan-based nanocomposites. Finally, the versatile applications of chitosan, whether in its native state, derived or incorporated into nanocomposites in various fields, such as the food industry, agriculture, the cosmetics industry, the pharmaceutical industry, medicine, and wastewater treatment, were discussed.

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Local Delivery of Metronidazole-loaded N-Trimethyl Quaternary Ammonium Chitosan Nanoparticles for Periodontitis Treatment

Cited by 3 publications

References 35 publications

Green Nanomaterials Zinc Oxide and Chitosan for Antimicrobial Activity Against Oral Pathogens

Green Nanomaterials Zinc Oxide and Chitosan for Antimicrobial Activity Against Oral Pathogens

Assessment of Effect of Intra-pocket Delivery of Metronidazole Loaded NTrimethyl Quaternary Ammonium Chitosan Nanoparticles in Treatment of Periodontal Disease

Chitosan, chitosan derivatives, and chitosan-based nanocomposites: eco-friendly materials for advanced applications (a review)

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