Local delivery of resveratrol using polycaprolactone nanofibers for treatment of periodontal disease

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

“…Some of the secarrier systems and their roles in periodontal disease therapy are summarized in Table 1. Minocycline-loaded nanoparticles could significantly decrease symptoms of periodontitis (Yao et al, 2014) Calcium and zincloaded bioactive and cytocompatible nanoparticles represent a promising tool for therapeutic approach in periodontal regeneration (Osorio et al, 2016) Nanogels Nanogels of cholesterolbearing pullulan modified with amino groups (CHPNH2) were utilized as a career to introduce QDs into PDL cells (Fukui et al, 2007) CHPNH2-QD nanoparticles are useful for further characterization of PDL cells and investigation of regenerative processes of periodontium (Fukui et al, 2007) Nanocomposites Thin layer of nanocomposites has been used to provide coating on tooth surface, which strongly reduced biofilm formation (Hannig et al, 2007) Nanocomposite hydrogels were synthesized as model systems and it offers flexibility for local placement of drugs in the treatment of periodontal disease (Bako et al, 2008) Dental bioactive nanocomposite composed of 2-methacryloyloxyethyl phosphoryl choline and dimethylamino hexadecyl methacrylate is promising for Class V restorations to inhibit periodontal pathogens, combat periodontitis and protect the periodontium (Wang et al, 2016) Nanofibers Poly-ε-caprolactone (PCL) nanofibers containing metronidazole showed prolonged sustained drug release for at least 19 days and can be used as a retentive, locally controlled delivery system for metronidazole in periodontal diseases treatment (Chaturvedi et al, 2012;Zamani et al, 2010) Low-dose controlledrelease PCL nanofibers containing doxycycline showed sustained drug release and can be used as a retentive controlled delivery system for the treatment of periodontal diseases (Chaturvedi et al, 2013) Drug loaded hyaluronic acid-polyvinyl alcohol nanofiber patch presented controlled release behavior with good mucoadhesive strength (Joshi et al, 2015) The in vivo studies confirmed the maintenance of minimum inhibitory concentration over an extended period in addition to a significant anti-inflammatory effect, which suggested the formulation's role as an intra-periodontal pocket drug delivery system (Joshi et al, 2015) Resveratrol-loaded PCL nanofibers improved low solubility and stability of resveratrol and it can supply the drug for treatment of periodontal disease in the periodontal pocket even longer due to sustained release and low gingival fluid flow (Zupančič et al, 2015a) …”

“…There are various promising nanotechnology-based approaches in the field of nanodentistry that are being investigated or developed for dental therapy such as nanofibers, nanotubes, nanocapsules, nanopores, quantum dots (QDs), dendrimers, nanoshells, nanofillers, nanorods, nanorings, fullerenes, nanospheres, nanowires and nanobelts (Chen et al, 2016;Kong et al, 2006;Zupančič et al,2015a). Some of these approaches have demonstrated satisfactory outcomes toward minimizing undesirable side-effects for various active agents while maximizing the therapeutic activity.…”

Electrospinning and Drug Delivery

“…Prolonged drug release was attained from gelatin-ciprofloxacin nanofibers coating along with initial rapid drug release of around 20-22% during 12 h, followed by a slow release stage that can effectively control the infection [68]. Moreover, resveratrol (a promising natural substance for periodontal disease treatment due to its anti-inflammatory and antioxidative effects) was successfully incorporated into polycaprolactone-nanofibers and enabled a biphasic-release kinetic pattern [69]. In a recent study, it was demonstrated that the production of core-shell fibers via modified coaxial electrospinning achieved controlled release of ampicillin-loaded polycaprolactone nanofibers covered by a polycaprolactone shield.…”

Preparation, Characterization, and Antitumor Evaluation of Electrospun Resveratrol Loaded Nanofibers

“…For example, Zupančič et al successfully constructed Rsv-loaded nanofibers with PCL as drug carriers. They characterized the nanofiber by FTIR, DSC, and so forth with no further evaluation on the anticancer effect [28]. Here we studied the in vitro antitumor effect of Rsv-NFs through XTT assay, proliferation and apoptosis staining, and clonogenic assay.…”