Local Differences in the Trabecular Bone Structure of the Proximal Femur Depicted with High-Spatial-Resolution MR Imaging and Multisection CT

Issever, Ahi Sema; Vieth, Volker; Lotter, Albrecht; Meier, Norbert; Laib, Andres; Newitt, David C.; Majumdar, Sharmila; Link, Thomas M.

doi:10.1016/s1076-6332(03)80667-0

Cited by 56 publications

(34 citation statements)

References 48 publications

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“…Many approaches exist for the problem of image segmentation within the fields of computer vision, medical imaging, and aerial photography [16]. The most common method implemented is based on choice of attenuation thresholds [17][18][19]. Here, we illustrate the errors that arise when using this commonly implemented segmentation method for the three-phase system in Fig.…”

Section: Phase Separationmentioning

confidence: 99%

Assessment of bone ingrowth into porous biomaterials using MICRO-CT

Jones¹,

Arns²,

Sheppard³

et al. 2007

Biomaterials

391

266

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Section: Phase Separationmentioning

confidence: 99%

Assessment of bone ingrowth into porous biomaterials using MICRO-CT

Jones¹,

Arns²,

Sheppard³

et al. 2007

Biomaterials

391

266

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“…Structural variations in the trabecular bone of the proximal femur have recently been described by Issever et al [28], who measured architectural variables in 36 proximal femur cadaveric specimens using DXA, high-resolution MRI, multisection CT, and micro-CT (in a subset) in identical regions of interest of trabecular bone. Trabecular bone structural parameters were obtained, and the parameters from the individual imaging techniques and BMD were correlated.…”

Section: Computed Tomography and Magnetic Resonance Imagingmentioning

confidence: 94%

Sex and ethnic differences in bone architecture

Nelson

Megyesi²

2004

Curr Osteoporos Rep

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Technologic developments and applications such as dual energy x-ray absorptiometry, magnetic resonance imaging, and computed tomography have enabled researchers to assess bone quantity (ie, bone mineral density) and bone quality (ie, bone architecture), which are two important and independent contributions to bone strength. Recent studies on sex differences in bone architecture indicate that a number of biomechanical variables lead to increased bone strength in males compared with females. Ethnic differences in bone architecture are less clear-cut, indicating a need to identify and test the social and biologic variables that race and ethnicity represent. New methods using magnetic resonance imaging technology may become important in creating efficient and reliable in vivo methods of assessing features of bone architecture that are relevant to fracture risk and contribute to the elucidation of sex and ethnic differences in osteoporosis.

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“…The dimensions of individual trabeculae, which range between 50 and 200 µm, are comparable to the best achievable MRI spatial resolution, which may cause problems due to "partial volume effects," where a pixel contains elements of both bone and marrow at the surface interface. The assignment of such a pixel to either bone or marrow may significantly alter the postprocessing image obtained [20], and necessitate development of various methods to segment MRI images into bone and marrow [15,16,21,22]. After processing the MRI images, morphologic parameters analogous to the standard bone histomorphometry can be obtained.…”

Section: Three-dimensional Methods For Studying Bone Microarchitecturementioning

confidence: 99%

Noninvasive assessment of bone structure

Vokes

Favus²

2003

Curr Osteoporos Rep

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Bone fragility is determined by bone mass and trabecular structure. While bone mass can be readily measured as bone density, bone trabecular structure cannot be easily assessed by currently available methods. The realization of the importance of bone structure in determining fracture risk has led to the development of several imaging modalities aimed at evaluating the contribution of bone quality to its biomechanical strength and fragility. High-resolution magnetic resonance imaging and computed tomography have limited spatial resolution and high cost but have a potential to generate true three-dimensional images of trabecular structure in vivo. Bone radiographs subjected to various forms of texture analysis have higher resolution and lower cost but provide only a two-dimensional representation of bone structure. Both two- and three-dimensional methods have been shown to predict biomechanical strength in vitro and to differentiate between subjects with and without fractures in vivo. Therefore, all of these methods deserve closer evaluation and also need further technical improvements before they can be considered for use in clinical practice.

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Local Differences in the Trabecular Bone Structure of the Proximal Femur Depicted with High-Spatial-Resolution MR Imaging and Multisection CT

Cited by 56 publications

References 48 publications

Assessment of bone ingrowth into porous biomaterials using MICRO-CT

Assessment of bone ingrowth into porous biomaterials using MICRO-CT

Sex and ethnic differences in bone architecture

Noninvasive assessment of bone structure

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