A set of multipartite orthogonal quantum states is strongly nonlocal if it is locally irreducible for every bipartition of the subsystems [Phys. Rev. Lett. 122, 040403 (2019)]. Although this property has been shown in three-, four-and five-partite systems, the existence of strongly nonlocal sets in N -partite systems remains unknown when N ≥ 6. In this paper, we successfully show that a strongly nonlocal set of orthogonal entangled states exists in (C d ) ⊗N for all N ≥ 3 and d ≥ 2, which for the first time reveals the strong quantum nonlocality in general N -partite systems. For N = 3 or 4 and d ≥ 3, we present a strongly nonlocal set consisting of genuinely entangled states, which has a smaller size than any known strongly nonlocal orthogonal product set. Finally, we connect strong quantum nonlocality with local hiding of information as an application.