Local heat stress and skin blood flowmotion in subjects with familial predisposition or newly diagnosed hypertension

Gryglewska, Barbara; Nęcki, Mirosław; Cwynar, Marcin; Baron, Tomasz; Grodzicki, Tomasz

doi:10.3109/08037051.2010.488053

Cited by 12 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sheppard et al [34] using wavelet based analysis similarly reported a decrease in the myogenic band in the hand during warming, as did Gryglewska et al [35] using a Fast Fourier Transform (FFT). However, Hodges et al [36] also using FFT reported warming-induced increases in the three LF bands at both the forearm and the leg in young healthy individuals.…”

Section: B Power-frequency Profiles In Low Vs High Flow Statesmentioning

confidence: 92%

“…Greater variability may also indicate an ability to influence flow independently of the spectral amplitude of flowmotion [16]. Thus a declining spontaneous variation in flowmotion activity as seen in vascular beds at risk of CV and Met disease [14] may contribute to a loss of system flexibility and adaptability in the face of physiological or pathological challenge.…”

Section: Complexity Of Network Perfusion and Oxygenation In Low Vsmentioning

confidence: 99%

“…While in humans with a familial predisposition to hypertension, altered microvascular haemodynamics have been associated with diminished chaotic ischaemic flow [16]. More recently, chaotic network attractor analysis [17,18] has revealed a declining adaptability of microvascular flow patterns in rodent models of CV and Met disease [2].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Time-dependent Behavior of Microvascular Blood Flow and Oxygenation: a Predictor of Functional Outcomes

Kuliga

Gush

Clough

et al. 2017

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Abstract-Objective:This study investigates the timedependent behaviour and algorithmic complexity of low frequency, periodic oscillations in blood flux and oxygenation signals from the microvasculature. Methods: Microvascular blood flux (BF) and oxygenation (OXY: oxyHb, deoxyHb, totalHb and SO 2 %) was recorded from 15 healthy young adult males using combined laser Doppler fluximetry and white light spectroscopy with local skin temperature clamped to 33°C and during local thermal hyperaemia (LTH) at 43°C. Power spectral density (PSD) of the BF and OXY signals was evaluated within the frequency range (0.0095-1.6Hz). Signal complexity was determined using the Lempel-Ziv (LZ) algorithm. Results: Foldincrease in BF during LTH was 15.6 (10.3,22.8) and in OxyHb 4.8 (3.5,5.9) (median, range). All BF and OXY signals exhibited multiple oscillatory components with clear differences in signal power distribution across frequency bands at 33°C and 43°C. Significant reduction in the intrinsic variability and complexity of the microvascular signals during LTH was found, with mean LZ complexity of BF and OxyHb falling by 25% and 49%, respectively (p<0.001). Conclusion: These results provide corroboration that in human skin microvascular blood flow and oxygenation are influenced by multiple, time-varying oscillators that adapt to local influences and become more predictable during increased haemodynamic flow. Significance: Recent evidence strongly suggests that the inability of microvascular networks to adapt to an imposed stressor is symptomatic of disease risk which might be assessed via BF and OXY via the combination signal analysis techniques described here.

show abstract

Section: B Power-frequency Profiles In Low Vs High Flow Statesmentioning

confidence: 92%

Section: Complexity Of Network Perfusion and Oxygenation In Low Vsmentioning

confidence: 99%

See 1 more Smart Citation

Time-dependent Behavior of Microvascular Blood Flow and Oxygenation: a Predictor of Functional Outcomes

Kuliga

Gush

Clough

et al. 2017

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

“…Normotensive men with a positive family history of hypertension showed an increased diastolic blood pressure after isometric handgrip testing when compared to controls without a family history of hypertension (Widgren et al, 1992). Similarly, the microcirculation response to local heat stress and skin blood flow is altered in normotensive with family history of hypertension (Gryglewska et al, 2010). In a cohort of adults and their children followed for six years, this increased response to stress was the strongest in the subjects found to display the highest diastolic and systolic blood pressure six years later.…”

Section: Enhanced Stress Response Is Predictive Of Hypertension -Concmentioning

confidence: 95%

Radio-Telemetry in Biomedical Research - Radio-Telemetry Blood Pressure Measurements in Animal Models of Hypertension, How It Revolutionized Hypertension Research

Dumas¹,

Chiche²,

Tremblay³

et al. 2011

Modern Telemetry

View full text Add to dashboard Cite

“…These periodic oscillations, or skin flowmotion, represent the influence of heart beat (0.6–2.0Hz), respiration (0.15–0.6Hz), myogenic (~0.05–0.15Hz) (Stefanovska et al, 1999), neurogenic (~0.02–0.05Hz) (Kastrup et al, 1989; Soderstrom et al, 2003), and endothelial (~0.0095–0.02Hz) influences on vascular smooth muscle relaxation (Gustafsson et al, 1993; Kvandal et al, 2003; Kvernmo et al, 1999; Rossi et al, 2008a). Spectral analysis has been performed on populations with known microvascular dysfunction such as peripheral arterial obstructive disease (Rossi et al, 2005), chronic kidney disease (Rossi et al, 2008b), diabetes (Schmiedel et al, 2007), chronic smokers (Avery et al, 2009; Rossi et al, 2007), hypercholesterolemics (Rossi et al, 2009) and essential hypertensive men and women (Gryglewska et al, 2010a; Gryglewska et al, 2010b; Rossi et al, 2006). While these studies observed altered skin flowmotion responses, many of them utilized different skin vasoreactivity tests and subject populations in which the mechanisms mediating skin blood flow are not thoroughly understood.…”

Section: Introductionmentioning

confidence: 99%

Altered skin flowmotion in hypertensive humans

Bruning

Kenney

Alexander

2015

Microvascular Research

View full text Add to dashboard Cite

Essential hypertensive humans exhibit attenuated cutaneous nitric oxide (NO)-dependent vasodilation. Using spectral analysis (fast Fourier transformation) we aimed to characterize the skin flowmotion contained in the laser-Doppler flowmetry recordings during local heating-induced vasodilation before and after concurrent pharmacological inhibition of nitric oxide synthase (NOS) in hypertensive and age-matched normotensive men and women. We hypothesized that hypertensive subjects would have lower total power spectral densities (PSD), specifically in the frequency intervals associated with intrinsic endothelial and neurogenic control of the microvasculature. Furthermore, we hypothesized that NOS inhibition would attenuate the endothelial frequency interval. Laser-Doppler flowmetry recordings during local heating experiments from 18 hypertensive (MAP: 108±2mmHg) and 18 normotensive (MAP: 88±2mmHg) men and women were analyzed. Within site NO-dependent vasodilation was assessed by perfusion of a non-specific NOS inhibitor (NG-nitro-L-arginine methyl ester; L-NAME) through intradermal microdialysis during the heating-induced plateau in skin blood flow. Local heating-induced vasodilation increased total PSD for all frequency intervals (all p<0.001). Hypertensives had a lower total PSD (p=0.03) and absolute neurogenic frequency intervals (p<0.01) compared to the normotensives. When normalized as a percentage of total PSD, hypertensives had reduced neurogenic (p<0.001) and augmented myogenic contributions (p=0.04) to the total spectrum. NOS inhibition decreased total PSD (p<0.001) for both groups, but hypertensives exhibited lower absolute endothelial (p<0.01), neurogenic (p<0.05), and total PSD (p<0.001) frequency intervals compared to normotensives. These data suggest that essential hypertension results in altered neurogenic and NOS-dependent control of skin flowmotion and support the use of spectral analysis as a non-invasive technique to study vasoreactivity.

show abstract

Local heat stress and skin blood flowmotion in subjects with familial predisposition or newly diagnosed hypertension

Abstract: Skin microcirculation response to local heat stress is altered in hypertensive patients with decrease in maximal heat CVC values. Moreover, normotensive subjects with familial predisposition to hypertension are characterized by diminished myogenic origin of skin blood flowmotion.

Cited by 12 publications

References 30 publications

Time-dependent Behavior of Microvascular Blood Flow and Oxygenation: a Predictor of Functional Outcomes

Time-dependent Behavior of Microvascular Blood Flow and Oxygenation: a Predictor of Functional Outcomes

Radio-Telemetry in Biomedical Research - Radio-Telemetry Blood Pressure Measurements in Animal Models of Hypertension, How It Revolutionized Hypertension Research

Altered skin flowmotion in hypertensive humans

Contact Info

Product

Resources

About