Local hemodynamics affect monocytic cell adhesion to a three-dimensional flow model coated with E-selectin

Neutrophil Adhesion on Endothelial Cells in a Novel Asymmetric Stenosis Model: Effect of Wall Shear Stress Gradients

“…This is an area of increased shear stress as the geometry creates a positive shear gradient. Hinds et al found a similar increased adhesion of U-937 cells to the proximal part of the constriction in their idealized E-selectin coated axisymmetric stenosis (49). Taken together, our results and previous studies suggest that there is more firm attachment of leukocytes to an endothelium in the presence of complex shear gradients (31)(32)(33).…”

“…They hypothesize a longer residence time and a higher near wall concentration as cells roll more slowly in the reattachment point compared to other areas possibly causing this preferential attachment. In an axisymmetric stenosis model, Hinds et al found the attachment of U-937 cells to an E-selectin layer to be negatively correlated with the magnitude of wall shear stress in the constricted region (proximal) and stenosis region (49). It must be noted that this was a highly idealized stenosis model consisting of a linear constriction and reverse step, and the shear stress applied was an order of magnitude less than in our experiments.…”

The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis

“…It has also been shown for steady flow in perfusion models (Pritchard et al, 1995) that blood monocyte adhesion to the vessel wall is inversely correlated to wall shear stress and is strongly influenced by the magnitude of in-plane flow and the presence of flow separation. In addition a recent investigation by Hinds et al (2001) with both steady and pulsatile flow in a three dimensional perfusion model showed that blood monocyte adhesion was significantly higher in the locality of the flow separation region as compared to the post reattachment and pre-separation regions. They also found that flow pulsatility significantly altered monocyte adhesion patterns and introduced an overall more uniform adherent cell distribution.…”

Wall Shear Stress Distribution Inside Growing Cerebral Aneurysm

“…Low-velocity blood flow leads to increased leukocyte adhesion to endothelial cells, resulting in lesions in the arterial wall. 12 Low velocity causes an increased residence time of circulating particles in the region and mass transfer, thereby enhancing the interactions between circulating leukocytes and vascular endothelial cells. 13 Furthermore, Yamaguchi et al 14 reported that slow circulating flow contributed to thrombus formation, and they linked the process of fibrinolysis after thrombus formation to aneurysm wall digestion.…”