Local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata

Comparison of cure rates and durations of treatment with diphenylcyclopropenone immunotherapy for warts in children/adolescents and adults

“…A total of 143 patients with warts were included in this study. The children/adolescents consisted of 40 boys and 32 girls (age range [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] with an average age of 14.1. The adults consisted of 38 men and 33 women (age range 21-65) with an average age of 29.2.…”

“…The numbers of applications needed for sensitization in children/adolescents and adults were 2.31 AE 0.32 and 2.78 AE 0.54, respectively (P > 0.05). The responses of sensitization after two attempts were as follows: the EBIs of 63 children/adolescents were 0 (2), 1 (28), 2 (26), and 3 (7), and the average EBI was 1.66 AE 0.98. The PIs were 0 (2), 1 (24), 2 (32), and 3 (5), and the average PI was 1.71 AE 0.88.…”

“…4 Recently, immunotherapies such as photodynamic therapy and local hyperthermia have been successfully used to treat genital warts, but the mechanisms are still unclear. [5][6][7] Diphenylcyclopropenone (DPCP) is a topical sensitizer first synthesized in 1959 that has frequently been used for treating recalcitrant warts. Owing to its poor systemic absorption, DPCP is safer than other sensitizing agents.…”

Clearance of genital warts in pregnant women by mild local hyperthermia: a pilot report

“…The exact mechanism of wart clearance in our approach is still unclear. Local hyperthermia could promote migrational maturation of Langerhans cells , stimulate cytotoxic and apoptotic effects , and induce production of endogenous interferon in genital warts . In the two cases, we noted that patients with multiple warts experienced almost simultaneous clearance of targeted warts as well as the remaining untargeted warts (in case 1, remote warts on the vaginal wall were unable to be followed regularly because of the patient's fear of virus transmission by examination).…”

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses

“…This has proved a valuable approach as indicated by improved therapeutic efficacies and reductions in recurrence rates as compared to conventional therapies [9]. Preliminary results from our, as well as other, laboratories have revealed that the therapeutic effects of local hyperthermia in treating cancers and HPV-infectious diseases were, in part, due to its immune-stimulating actions resulting in enhanced antigen presentation [10] and/or the induction of immune-active molecules [11]. However, much of the underlying mechanisms of local hyperthermia therapy, especially in treatment against HPV infection, remains unknown and requires further investigation.…”