Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses

Sun, Yuzhe; Li, Jiafeng; Wei, Zhen-Dong; Jiang, Hao; Hong, Yuxiao; Zheng, Song Guo; Qi, Ruiqun; Gao, Xing‐Hua

doi:10.1080/02656736.2019.1578420

Cited by 9 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of absorptivity and penetration depth, the red light of 635 nm is the most commonly used clinical light source. At present, LED light source is widely used [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Wang

Hong

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

A case-control study is performed in this paper to explore various possible effects and clinical value of the photodynamic therapy combined with thymosin for the treatment process of the condyloma acuminatum (CA) in the anal canal. For this purpose, a hundred (100) patients specifically with CA in the anal canal who were regularly treated in the hospital from February 2019 to April 2021 were recruited. The first group, that is, the control group, was treated with thymosin, whereas photodynamic therapy combined with thymosin was used as a treatment for the study group. The curative effect, clinical index, LTN, SP, TGF-β 1, TNF-α, CD3+, CD4+, CD8+, and the adverse reactions of incidence were compared between these groups. Moreover, 27 cases were observed to be obviously effective, 22 were observed to be effective, and a single case was observed to be ineffective. Thus, 98% is the total effective rate where a single case relapses. Likewise, in the control group, 15 cases were observed to be obviously effective, 28 effective, and 13 ineffective. Thus, 86% is the total rate of effectiveness where thirteen (13) cases relapse. We have observed that the study group has a higher rate of effectiveness than the control group and the rate of recurrence of the former group was slightly lower than that of the latter group, that is, the control group ( P < 0.05). In addition, the time of symptom improvement, the amount of bleeding, the disappearance time of bloody stool, and the time of the first recurrence of the study group were observed to be lower than those of the control group ( P < 0.05). In levels of LTN and SP, we have observed no or zero significant differences between these groups before treatment. However, LTN’s levels of both groups increased after the treatment, and SP’s level decreased. LTN’s level of the study group was observed to be higher than that of the other group, and SP’s level in the former group was lower than that in the latter group. Zero significant differences were observed in the TGF-β 1 and TNF-α’s levels between these groups before treatment, but the level of TGF-β 1 and TNF-α has increased and decreased, respectively, in both groups specifically after treatment. The level of TGF-β 1 in the former group was observed to be slightly higher than that in the latter group, that is, the control group, while TNF-α’s level in the study group was lower than that in the control group. We have not observed any significant difference in CD4+, CD3+, and CD8+ levels between these groups before treatment. However, after treatment, CD3+ and CD4+ levels increased, and the levels of CD8+ decreased in both groups, while CD3+ and CD4+ levels in the former group were evident to be higher than those in the latter group and the level of the CD8+ in the study group was observed to be lower than that in the control group. Finally, we compared the adverse reactions of incidence between these groups. There were 4 cases of tingling sensation and 1 case of redness and swelling in the group study along with a total incidence of 10%. There were 5 cases of tingling sensation and 2 cases of redness and swelling in the control group along with a total incidence of 14%. The incidence of adverse reactions in the study group was observed to be slightly lower than that in the control group, but a significant difference was not observed between these groups (χ2 = 0.378; P > 0.05).

show abstract

“…In terms of absorptivity and penetration depth, the red light of 635 nm is the most commonly used clinical light source. At present, LED light source is widely used [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Wang

Hong

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…Local hyperthermia decreases enzymes and molecules related to keratinocyte differentiation in wart tissue, such as KRT5, KRT27, KRT75, KRT76, and H2AFY2, and inhibits proteins involved in cellular metabolism, such as GALT, H6PD, EXOSC4, and EXOSC6; conversely, it promotes the expression of proteins involved in antiviral processes, such as OAS1, MX1, BANF1, CANX. 10 In addition, local hyperthermia also promotes the maturation of Langerhans cells and induces a systemic anti-HPV immune response, thus leading to the regression of lesions at unirradiated sites as well. 11 Jiang et al reported a case of periungual warts in a 9-year-old child successfully treated with local hyperthermia.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment in a Child with Refractory Periungual Warts by Local Hyperthermia: A Case Report

Du¹,

Cao²,

Zhu³

et al. 2022

CCID

View full text Add to dashboard Cite

Periungual wart is a kind of verruca vulgaris that occurs alongside or underlying the nails, which is challenging to treat and prone to recurrence, seriously affecting the quality of patients’ life. We report a 6-year-old boy with periungual warts who had experienced various treatments with no improvement and even worsening. Therefore, we tried to treat the patient with local hyperthermia which uses a patented device that has an infrared emission source. The heat generated by infrared rays acts on the local skin surface. The mechanism of this therapy may be to establish a specific immune response against human papillomavirus-infected tissues, thereby facilitating the clearance of human papillomavirus at irradiated and non-irradiated sites. Local hyperthermia has the advantages of non-contact, safety, noninvasive, less pain, and so on. After 5 treatments, the irradiated periungual warts completely cleared after 2 weeks. The unirradiated sites were almost cured after 7 weeks. This case suggests that local thermotherapy has shown great advantages in the treatment of these refractory periungual warts and offers a new and effective therapy in patients with periungual warts.

show abstract

“…Specifically, T cellular immunity plays significant roles in the activation of HPV and the occurrence, cure, and relapse of CA. In addition, previous studies have reported the existence of cellular immunity dysfunction in CA patients, 13,14 including disproportional peripheral blood T lymphocyte subsets, an abnormal rate of natural killer cells, and an imbalance of cellular factors, for example, interleukins. These aberrations of cellular immunity will eventually protect the virus from immune system attack.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a combination therapy of traditional Chinese medicine and CO₂ laser treatment for condyloma acuminatum

Shen

Fan

et al. 2020

Journal of Medical Virology

View full text Add to dashboard Cite

Background Condyloma acuminatum (CA) is both highly infectious and frequently recurring and requires long‐term, repeated treatments, which seriously affect the physical and psychological health of patients. The purpose of the present study was to investigate the effectiveness of a combination therapy of traditional Chinese medicine and CO2 laser on CA and the relationship between CA relapse and cellular immunity. Methods The study cohort consisted of 160 CA patients who underwent ambulatory treatment between January 2017 and January 2019 in the Department of Dermatology and Venerology of our hospital. The 160 patients were randomly divided into two groups: a combination therapy group (80 cases), who underwent CO2‐laser treatment followed by three courses of oral traditional Chinese medicine and a control group (80 cases), who were only treated with the CO2 laser to remove warts. The efficacy of the CO2‐laser treatment was evaluated on the first month after treatment and relapse was evaluated at monthly follow‐ups for 6 months. Additionally, 20 normal volunteers were also recruited. Three months before and after treatment, the cellular immunity factors of peripheral blood T lymphocyte subsets, including CD4+, CD8+, CD4+/CD8+, and interleukin‐2 (IL‐2), were detected and compared between CA patients and normal volunteers, the combination therapy and control groups, and the relapse and cure groups to determine whether there were statistical differences. Results Compared with normal volunteers, CA patients exhibited lower CD4+, CD4+/CD8+, and IL‐2 levels and higher CD8+ levels (P < .05). In addition, the rates of relapse for the combination therapy and control groups were 25.7% and 40.8%, respectively. However, the comprehensive immunity factors showed no statistical difference (P > .05) before treatment. Three months after treatment, factors including CD4+ and CD4+/CD8+ were higher in the combination therapy group than in the control group (P < .05), and CD8+ and IL‐2 showed no statistical difference (P > .05); factors including CD4+, CD4+/CD8+, and IL‐2 were higher and CD8+ was lower in the cure group than in the relapse group (P < .05). Conclusion The therapy combination of traditional Chinese medicine and CO2‐laser treatment can reduce the relapse rate of CA. It might be that traditional Chinese medicine combined with CO2‐laser treatment regulate liver meridian, Qi and blood, and restore the balance between various subgroups.

show abstract

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses

Cited by 9 publications

References 35 publications

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Successful Treatment in a Child with Refractory Periungual Warts by Local Hyperthermia: A Case Report

Effectiveness of a combination therapy of traditional Chinese medicine and CO₂ laser treatment for condyloma acuminatum

Contact Info

Product

Resources

About

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses

Cited by 9 publications

References 35 publications

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Successful Treatment in a Child with Refractory Periungual Warts by Local Hyperthermia: A Case Report

Effectiveness of a combination therapy of traditional Chinese medicine and CO2 laser treatment for condyloma acuminatum

Contact Info

Product

Resources

About

Effectiveness of a combination therapy of traditional Chinese medicine and CO₂ laser treatment for condyloma acuminatum