Local hyperthermia could induce migrational maturation of Langerhans cells in condyloma acuminatum

Li, Xiaodong; Gao, Xing‐Hua; Wang, Yakun; Hong, Yuxiao; Mchepange, Uwesu Omari; Wang, Xiaoqin; Jiang, Yi; Wei, Huachen; Chen, Hong‐Duo

doi:10.1016/j.jdermsci.2008.12.004

Cited by 33 publications

(38 citation statements)

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“…We recently noted that local hyperthermia could promote migrational maturation of Langerhans cells (LCs) in both normal and HPV-infected skin and that the effect was stronger at a local hyperthermia temperature of 44ЊC than at 42ЊC; the results suggested that hyperthermia might augment the antigen-presenting capability of LCs [9]. We have also observed that hyperthermia at 41ЊC reduced the numbers of mouse epidermal LCs, which minimized on day 3 and then gradually returned to the original levels on day 7 (authors' unpublished observation).…”

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confidence: 99%

Local Hyperthermia at 44°C for the Treatment of Plantar Warts: A Randomized, Patient‐Blinded, Placebo‐Controlled Trial

et al. 2010

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There have been anecdotal reports that local hyperthermia was effective in the treatment of viral warts. We conducted a randomized, patient-blinded, placebo-controlled trial to test the effect of local hyperthermia (44 degrees C for 30 min a day for 3 consecutive days plus 2 additional days 2 weeks later) on plantar warts. By the end of 3 months, 53.57% of patients (15/28) in the treatment group and 11.54% of patients (3/26) in the control group were cured (P < .01). The effect was not influenced by patient age, duration of disease, or number or size of lesions.

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confidence: 99%

Local Hyperthermia at 44°C for the Treatment of Plantar Warts: A Randomized, Patient‐Blinded, Placebo‐Controlled Trial

et al. 2010

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“…Local hyperthermia at 428C and 458C was shown to promote the migration and maturation of Langerhans cells in normal human skin, and these effects were even more pronounced in condyloma acuminatumeinfected skin. 160 The histopathologic examination of sections from hyperthermia-treated or cryotreated warts revealed a significant increase in the amount of mononuclear infiltrate in the dermis with exocytosis, supporting the concept of wart clearance through a cell-medicated immune response. 58 It is conceivable that a systemic immune response may be triggered by localized heat application, given that thermotherapy of single lesions has been accompanied by resolution of warts at distant body sites.…”

Section: Thermotherapymentioning

confidence: 66%

Thermotherapy in dermatologic infections

Doherty

Rosen

2010

Journal of the American Academy of Dermatology

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“…Therefore, the tar(T) should be kept within an appropriate range. An optimal temperature range for LH is considered to be from 42 ∘ C to 45 ∘ C; this range promotes the migration and maturation of Langerhans cells [14], which activate immune responses.…”

Section: Discussionmentioning

confidence: 99%

“…Temperature-controlled systems using the combination of a hyperthermic apparatus and a noninvasive temperature monitor have been developed, and some of them have been used clinically [3,7,8,10,[14][15][16]. A noncontact type thermal monitoring system, other than thermography, has also been reported [3,10,14]; however, it only shows one value for the average temperature in a certain area.…”

Section: Discussionmentioning

confidence: 99%

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Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia

et al. 2017

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Laser hyperthermia is a powerful therapeutic modality that suppresses the growth of proliferative lesions. In hyperthermia, the optimal temperature range is dependent on the disease; thus, a temperature-driven laser output control system is desirable. Such a laser output control system, integrated with a thermal sensor circuit based on thermography, has been established. In this study, the feasibility of the developed system was examined by irradiating mouse skin. The system is composed of a thermograph, a thermal sensor circuit (PC and microcontroller), and an infrared laser. Based on the maximum temperature in the laser-irradiated area acquired every 100 ms during irradiation, the laser power was controlled such that the maximum temperature was maintained at a preset value. Temperature-controlled laser hyperthermia using the thermal sensor circuit was shown to suppress temperature fluctuations during irradiation (SD ∼ 0.14 ∘ C) to less than 1/10 of those seen without the thermal sensor circuit (SD ∼ 1.6 ∘ C). The thermal sensor circuit was able to satisfactorily stabilize the temperature at the preset value. This system can therefore provide noncontact laser hyperthermia with the ability to maintain a constant temperature in the irradiated area.

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Local hyperthermia could induce migrational maturation of Langerhans cells in condyloma acuminatum

Cited by 33 publications

References 10 publications

Local Hyperthermia at 44°C for the Treatment of Plantar Warts: A Randomized, Patient‐Blinded, Placebo‐Controlled Trial

Local Hyperthermia at 44°C for the Treatment of Plantar Warts: A Randomized, Patient‐Blinded, Placebo‐Controlled Trial

Thermotherapy in dermatologic infections

Thermal Sensor Circuit Using Thermography for Temperature-Controlled Laser Hyperthermia

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