Local Hyperthermia for Superficial and Moderately Deep Tumors--Factors Affecting Response

Hyperfractionated Thermoradiotherapy Is More Effective and Less Invasive Than Radiation or Chemoradiation in Heatable Cancers: A Meta-Analysis

“…(2) Complete response rates were gratifying. Results of thermoradiotherapy confirmed our previous experience [16,[21][22][23][24][25][26]. Breast tumors showed a compete response rate (CR) of 82%.…”

Thermoradiotherapy with curative intent - Breast, head, neck and prostate tumors

“…Since most of these recurrences followed failure of high dose radiation, hyperthermia was combined with low dose radiation. In general the responses were better with heat and low doses of radiation than with mega doses of radiation alone [13,44].…”

“…Streffer, Leeper et al [24] and Gerwick et al [22,23] demonstrated that under low pH conditions, the phenomenon of thermotolerance is and in clinical studies [3-5, 11, 15, 25, 27, 36, 38-40, 45-47]. Early patient studies were mainly done in recurrent nodes in chest wall or neck locations [3-5, 25, 39] as well as cutaneous deposits of malignant melanoma or lymphoma [13,36]. Since most of these recurrences followed failure of high dose radiation, hyperthermia was combined with low dose radiation.…”

“…Based on these early results and our own experience [11][12][13][14][15]21] as well as several prospective randomized trials proving the safety and efficacy of thermoradiotherapy [40,47,52] we undertook to treat "de novo" a subpopulation of patients that refused conventional treatment. The safety and efficacy of thermoradiotherapy has been often proved, but a reluctance still exists to make the modal- …”