Local Increase in Hyaluronic Acid and Interleukin-2 in the Capsules Surrounding Silicone Breast Implants

Wells, Alvin F.; Daniels, Stephanie M.; Gunasekaran, Sivaselvi; Wells, Karen

doi:10.1097/00000637-199407000-00001

Cited by 22 publications

(11 citation statements)

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“…Inflammatory cells and various cytokines have been identified in the fibrous capsule around failed breast prosthesis [12]. Numerous studies have related the inflammation and activation of cells with release of cytokines, to individual chemical components of the silicone shell [13]. Experimental studies in rats have dealt with the tissue response around silicone expander.…”

Section: Discussionmentioning

confidence: 99%

Investigative Study of Myofibroblasts and Cytokines in Peri-Implant Tissue of Silicone Breast Expander by RT-PCR in a Rat Model

Joseph

Mohanty

Mohanan

2010

Journal of Biomaterials Science, Polymer Edition

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The excessive collagen deposition around silicone breast implants followed by contracture and development of severe pain is a major clinical problem. This study was conducted to investigate the profibrotic and antifibrotic cytokines secreted by inflammatory cells and development of myofibroblasts at the tissue material interface around silicone breast expander and ultra-high-molecular-weight polyethylene (UHMWPE). Both materials were implanted in rats for 30, 90 and 180 days. Inflammatory cells and collagen deposition at the material-tissue interface were assessed with Haematoxylin-Eosin and Masson's Trichrome stain. Gene expression of TGFbeta, IL-1beta, IFNgamma, IL10 and alpha-SMA was quantitated by real-time (RT)-PCR in the peri-implant tissue. Results indicate a difference in collagen deposition and myofibroblast development around both materials with involvement of TGFbeta, IFNgamma and IL10. The results emphasise the need for further investigation into the molecular mechanisms of protomyofibroblast and myofibroblast formation around silicone implants, which would provide information on these target cells for inhibitory therapy in the clinical situation.

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Section: Discussionmentioning

confidence: 99%

Investigative Study of Myofibroblasts and Cytokines in Peri-Implant Tissue of Silicone Breast Expander by RT-PCR in a Rat Model

Joseph

Mohanty

Mohanan

2010

Journal of Biomaterials Science, Polymer Edition

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“…Silicone gel was also observed to influence macrophage inhibition responses in guinea pigs (31), suggesting a modulation of IFNy. Silicone was shown to stimulate an intense lymphocytic response (32), and elevated levels of IL-2 have been detected in the capsular tissue surrounding the implant (33). Immune responses to silicone have recently been reported in both humans and mice (12, [34][35][36], although the specificity of antibodies and cellular responses to silicone remain controversial (37,38).…”

Section: Discussionmentioning

confidence: 99%

The influence of silicone implantation on type II collagen‐induced arthritis in mice

Schaefer

Whalen

Knapp³

et al. 1997

Arthritis & Rheumatism

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Objective. To determine whether silicone implantation exacerbates autoimmune disease in a murine experimental model of arthritis.Methods. DBA/l mice were implanted with silicone in the form of an elastomer, gel, or oil, and immunized with type I1 collagen. The influence of silicone implantation on collagen-induced arthritis and the immune response to type I1 collagen were determined by comparison against control mice receiving sham implantation. Adjuvant effects of silicone implantation were examined by measuring cytokine levels in implanted animals and assessing autoantibodies against proteins extracted from recovered silicone implants.Results. No adverse influence of silicone implantation on the clinical aspects of collagen-induced arthritis was observed. Further, polydimethylsiloxane silicone oil failed to serve as an adjuvant in the immune or arthritogenic response to type I1 collagen in mice. Cytokine analysis indicated that tumor necrosis factor a levels were lower and interleukin-2 levels were higher in silicone-implanted mice. The development of arthritis increased protein binding to implanted elastomers and gel, and autoantibodies against silicone-bound proteins were present in sera from arthritic mice and absent in sera from nonarthritic mice.Conclusion. The data suggest that silicone implantation may result in autoantibodies against silicone-bound proteins, and the presence of arthritis may either provoke or increase the level of such autoantibodies. However, silicone implantation did not inMs. Schaefer is the recipient of a Graduate Research Assistantship provided by Hutzel Hospital.

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“…[ 15,16 ] Here, the extent of post-operative infl ammatory events was fi rst assessed by counting immunocytologically stained infl ammation-specifi c cell types (CD4 + , CD8 + , CD68 + , TGFß1 + and fi broblasts) in capsule tissue samples from spider silk-coated and uncoated silicone implants extracted three, six or twelve months after implantation. In all tissue samples a chronic infl ammatory reaction was observed.…”

Section: Impact Of Spider Silk Coating On Capsule Thickness and Collamentioning

confidence: 99%

Spider Silk Coatings as a Bioshield to Reduce Periprosthetic Fibrous Capsule Formation

Zeplin

Maksimovikj

Jordan

et al. 2014

Adv Funct Materials

112

119

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Local Increase in Hyaluronic Acid and Interleukin-2 in the Capsules Surrounding Silicone Breast Implants

Cited by 22 publications

References 0 publications

Investigative Study of Myofibroblasts and Cytokines in Peri-Implant Tissue of Silicone Breast Expander by RT-PCR in a Rat Model

Investigative Study of Myofibroblasts and Cytokines in Peri-Implant Tissue of Silicone Breast Expander by RT-PCR in a Rat Model

The influence of silicone implantation on type II collagen‐induced arthritis in mice

Spider Silk Coatings as a Bioshield to Reduce Periprosthetic Fibrous Capsule Formation

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