Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization

Бараш, А. Н.; Dekel, Nava; Fieldust, Sheila; Segal, Ilana; Schechtman, Edna; Granot, Irit

doi:10.1016/s0015-0282(03)00345-5

Cited by 422 publications

(392 citation statements)

References 12 publications

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“…However, those reports varied in terms of the characteristics of the device that was used for injury, the degree of injury, and the timing of the intervention. Various devices have been used to injure the endometrium, such as hysteroscopes and biopsy catheters 1, 3, 4, 5, 6, 7, 9. In this study, an endometrial sampler was used that was considered to be an appropriate tool for inducing a mild endometrial injury.…”

Section: Discussionmentioning

confidence: 99%

“…One study stated that it is appropriate to take samples during the secretory phase of a cycle because injury‐induced decidualization is stimulated by progesterone 1. However, some studies have reported the effectiveness of injuring the endometrium during controlled ovarian hyperstimulation (COH) cycles 4, 9.…”

Section: Discussionmentioning

confidence: 99%

“…One possible cause for this is poor endometrial receptivity. Various approaches to addressing this problem have been explored and some recent studies have shown that local endometrial injury can improve both the implantation rates and pregnancy outcomes in patients with unexplained recurrent implantation failure 1, 2, 3, 4, 5, 6, 7, 8, 9…”

Section: Introductionmentioning

confidence: 99%

“…In 2003, a study reported that the sampling of the endometrium of IVF patients by using a biopsy catheter substantially increased their chances of conceiving during the subsequent IVF–embryo transfer cycles 1. Another study performed a systematic review and meta‐analysis in order to assess the efficiency of endometrial injury in participants with unexplained repeated implantation failure and found that local endometrial injury in the preceding ovarian stimulation cycles had a beneficial effect 2…”

Section: Introductionmentioning

confidence: 99%

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Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Matsumoto

Kokeguchi

Shiotani

2017

Reprod Medicine & Biology

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AimTo evaluate whether local endometrial injury would improve the pregnancy rates after frozen‐thawed blastocyst transfer in cycles with hormone replacement.MethodsSeventy‐seven patients who were aged <40 years with a history of at least three unsuccessful embryo transfers and who underwent frozen‐thawed blastocyst transfer during hormone replacement cycles between February and June, 2013 were studied. They were allocated into two groups based on the last digit of their clinical record number: an experimental group (n=22), excluding patients who withheld consent or who were unable to undergo treatment, and a control group (n=55). In the experimental group, the endometrium was scratched once with an endometrial sampler during the luteal phase of the cycle preceding the embryo transfer.ResultsThere was no significant difference in the baseline characteristics between the groups. The clinical pregnancy rate was 6% in the experimental group and 22% in the control group. Among these, the ongoing pregnancy rate was 100% in the experimental group and 50% in the control group.ConclusionEndometrial injury might increase the pregnancy rates after frozen‐thawed blastocyst transfer and decrease the risk of miscarriage in patients with a history of unsuccessful embryo transfers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Matsumoto

Kokeguchi

Shiotani

2017

Reprod Medicine & Biology

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“…Further studies involving direct examination of the endometrium are required in order to establish the mechanism of such an endometrial injury. Stimulation of the endometrium by local injury using an endometrial biopsy catheter was reported to be beneficial to patients with normal endometrial measurements who had otherwise unexplained repeated implantation failures [21,22]. However the patient population in this study differs significantly by having a functionally abnormal endometrium.…”

Section: Discussionmentioning

confidence: 84%

Thin unresponsive endometrium—a possible complication of surgical curettage compromising ART outcome

Shufaro

Simon

Laufer

et al. 2008

J Assist Reprod Genet

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Purpose Endometrial thickness is important for implantation. Little data addresses the etiology of persistently thin endometrium. We present a patient cohort in order to define common features and draw conclusions. Methods Thirteen out of 1,405 IVF patients repeatedly had thin unresponsive endometrium (<7 mm). Age, history, uterine cavity status, treatment type and outcome were examined. Results Patient age was 35.9±5.7 years. Ten patients had a curettage performed previously. Nine patients had normal cavity and endometrium, and in four adhesions were diagnosed and removed. Out of 99 cycles performed afterwards, endometrial thickness increased in 22. ETs were performed in 49 cycles resulting in 11 pregnancies. Their outcome was eight miscarriages, two terminations due to malformations, and one live birth. Conclusions Thin unresponsive endometrium was associated with curettage, not necessarily with intrauterine adhesions. Even if adequate thickening eventually occurred, the reproductive outcome was still very poor. Therefore other alternatives should be sought for these patients.

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Endometrial injury in women undergoing assisted reproductive techniques

Nastri

Gibreel

Raine‐Fenning

et al. 2011

CDSR

107

159

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Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization

Cited by 422 publications

References 12 publications

Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Effects of endometrial injury on frozen‐thawed blastocyst transfer in hormone replacement cycles

Thin unresponsive endometrium—a possible complication of surgical curettage compromising ART outcome

Endometrial injury in women undergoing assisted reproductive techniques

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