Local interleukin-2 and interleukin-12 therapy of bovine ocular squamous cell carcinomas

“…As medical treatment, intralesional immunotherapy with bacille Calmette‐Guerin (BCG) for large SCC in horses 18 and intralesional injections of interleukin‐2 in cattle have been described 19 . This technique is not suitable to treat corneal SCC.…”

Section: Discussionmentioning

confidence: 99%

Corneal squamous cell carcinoma in a Border Collie

Busse¹,

Sansom²,

Dubielzig³

et al. 2008

Veterinary Ophthalmology

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A 6-year-old, female, spayed Border Collie was presented to the Unit of Comparative Ophthalmology at the Animal Health Trust with a 6-month history of a progressive nonpainful opacity of the left cornea. A keratectomy was performed and the tissue submitted for histopathology. The diagnosis was squamous cell carcinoma. There has been no recurrence of the neoplasm to date (5 months). Canine corneal squamous cell carcinoma (SCC) has not been reported previously in the UK.

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“…Local IL-2 has shown impressive therapeutic effects in animal models with syngeneic transplanted cancer [11,14]. These results have been confirmed in veterinary [15,16] and human cancer patients [17][18][19].…”

Section: Introductionmentioning

confidence: 75%

Recurrences of Superficial Bladder Carcinoma are Associated with a Raise of CD8high>CD57+ and CD8low T Lymphocytes in Peripheral Blood

Jacobs¹,

Characiejus²,

Paukonien³

et al. 2010

TOCIJ

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Immunotherapy with BCG is effective in patients with recurrent superficial bladder carcinoma. This therapy involves Interleukin-2 (IL-2), but little is known about the immunological parameters involved in superficial bladder carcinoma. We have monitored immunological parameters in twenty patients with superficial bladder carcinoma treated with transurethral resection (TUR) followed by IL-2 instillation. Cell numbers of peripheral blood leukocyte subpopulations were counted before surgery and during follow-up after surgery. During follow-up, we compared the cell counts in patients with and without a recurrent tumour. We used the values of healthy matched controls as a reference. Recurrent disease in patients corresponded with a significant increase in CD8+ lymphocytes, and especially the CD8highCD57+ and CD8low subpopulations. The phenotype of these T lymphocytes belongs to cells with an immunosuppressive function. We hypothesize that these peripheral immune suppressive cells facilitate tumour recurrences or that tumour recurrences cause an increase in peripheral immune suppressive lymphocytes.

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Local interleukin-2 and interleukin-12 therapy of bovine ocular squamous cell carcinomas

Cited by 10 publications

References 26 publications

Local therapy of cancer with free IL-2

Local therapy of cancer with free IL-2

Corneal squamous cell carcinoma in a Border Collie

Recurrences of Superficial Bladder Carcinoma are Associated with a Raise of CD8high>CD57+ and CD8low T Lymphocytes in Peripheral Blood

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