Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats

Zhao, Wo Hua; Ji, Xun Ming; Li, Feng; Ding, Yu; Xing, Chang Hong; Wu, Hao; Guo, Miao; Xuan, Yang; Guan, Bo; Jiang, Ling

doi:10.1179/174313208x327982

Cited by 27 publications

(20 citation statements)

References 18 publications

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“…Consistent with previous findings (Chen et al, 2013;Ding et al, 2003;Ding et al, 2004a;Ding et al, 2004b;Luan et al, 2004;Zhao et al, 2009), we also clarified that transarterial regional hypothermia exerts strong neuroprotective effects on ischemia-reperfusion (I/R) injury (Kurisu et al, 2015). However, the effects of this therapy have only been examined in a typical ischemic stroke model, the transient middle cerebral artery occlusion (tMCAO) model (Chen et al, 2013;Ding et al, 2003;Ding et al, 2004a;Ding et al, 2004b;Kurisu et al, 2015;Luan et al, 2004;Zhao et al, 2009), which is a complete reperfusion model (Fluri et al, 2015;Takahashi et al, 2012;Zhao and Steinberg, 2011). The effects of this therapy have not yet been investigated in other ischemic stroke models, even though ischemic stroke in humans is extremely diverse in its pattern of occlusion and reperfusion in actual clinical settings.…”

Section: Introductionsupporting

confidence: 82%

“…The present study demonstrated that transarterial regional hypothermia exerts robust neuroprotective effects in the pMCAO with tCHP model, as well as the typical tMCAO model, as reported previously (Chen et al, 2013;Ding et al, 2003;Ding et al, 2004a;Ding et al, 2004b;Kurisu et al, 2015;Luan et al, 2004;Zhao et al, 2009). This therapy significantly improved neurological deficits and decreased infarct/edema volumes.…”

Section: Discussionsupporting

confidence: 62%

“…Transarterial regional hypothermia shows rapid and selective brain cooling in the model of pMCAO with tCHP as well as in the tMCAO model (Ding et al, 2003;Ding et al, 2004a;Ding et al, 2004b;Kurisu et al, 2015;Luan et al, 2004;Zhao et al, 2009). A comparison of the depth and duration of the cooling effect revealed that it was weaker in the model of pMCAO with tCHP than in the tMCAO model, but still mediated significant temperature lowering (2 to 3°C for 15 minutes).…”

Section: Discussionmentioning

confidence: 99%

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Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion

et al. 2016

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(248 words)The robust neuroprotective effects of transarterial regional hypothermia have been demonstrated in the typical transient middle cerebral artery occlusion (tMCAO) model, but have not yet been tested in other ischemic stroke models, even though clinical ischemic conditions are diverse. In order to clarify these effects in a different ischemic stroke model, we employed a rat model of permanent MCAO (pMCAO) with transient collateral hypoperfusion (tCHP), which was achieved by direct MCA ligation through craniotomy and 1-hour bilateral common carotid artery occlusion at the beginning of pMCAO. The infusion of 20 ml/kg of 4°C cold saline (CS) or 37°C warm saline (WS) into the ipsilateral internal carotid artery (ICA) was performed for 15 minutes in intraor post-tCHP. Neurological scores, infarct/edema volumes, and neuronal apoptosis and reactive gliosis were compared between the CS and WS groups and a non-infusion control group after 48 hours of reperfusion. Although brain temperatures were only reduced by 2-3°C for 15 minutes, the CS group had significantly better neurological scores, smaller infarct/edema volumes, and less penumbral neuronal apoptosis and reactive gliosis than the control and WS groups. The post-tCHP CS group exhibited prominent neuroprotective effects, even though infarct volumes and neuronal apoptosis were reduced less than those in the intra-tCHP CS group. In conclusion, we demonstrated the neuroprotective effects of transarterial regional hypothermia in an ischemic model of pMCAO with tCHP. Even though MCAO is persistent, cold infusion via the ICA is neuroprotective for the penumbra, suggesting the wider therapeutic application of this therapy.

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Section: Introductionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion

et al. 2016

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“…However in the present study we demonstrated that treatment with 4°C HRSS and 24°C HRSS significantly reduced ALT and AST level compared with the I/R injury group and no significant attenuate was seen after only hypothermic normal saline administration. Zhao et al indicated that Hypothermia could change various pathways involved in the pathogenic effects of cerebral ischemia, including reductions in metabolic and enzymatic activity, glutamate release and re-uptake, inflammation, reactive oxidant production, vascular permeability, blood-brain barrier disruption and the expression of a host of other genes (65).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model

Golshahi

Tavasoly

Mardjanmehr

et al. 2017

Braz. J. Vet. Pathol.

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Golshahi, et al.; Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model. Braz J Vet Pathol, 2017, 10(1), 10 -21. DOI: 10.24070/bjvp.1983 AbstractThe aim of the present study was to investigate the effects of intraportal administration of hypothermic hydrogenrich saline solution (HRSS) on hepatic ischemia/reperfusion (I/R) injury. Thirty rats were divided equally into six groups; 1) sham, no I/R or transfusion, 2) I/R injury (60 minutes ischemia + 120 minutes reperfusion, 3) I/R injury + normal saline 24°C, 4) I/R injury + normal saline 4°C, 5) I/R injury + HRSS 24°C, 6) I/R injury + HRSS 4°C. In groups 3-6, 1 mg/kg normal saline (NS) and/or HRSS were administered into the vein of the left lateral and median lobes of the liver (upper the site of clumping) 10 minutes before finishing of ischemic period. The harvest time points were at 2 hours post reperfusion in all groups. Cell death, sinusoidal dilatation, congestion, hemorrhage, and neutrophil infiltration were observed in I/R group, while these histopathological changes were attenuated in the hypothermic HRSS administrated groups (P < 0.01). The level of alanine aminotransferase, aspartate aminotransferase, malondialdehyde, interleukin 6, tumor necrosis factor a, and caspase-3 were increased significantly by I/R injury and hypothermic HRSS administration reduced all these markers (P < 0.01). SOD level was low in I/R group whereas it tended to increase in the hypothermic HRSS administrated groups (P < 0.01). The present study demonstrated that hypothermic hydrogen-rich saline solution effectively protected the hepatic tissue against cellular injury and organ dysfunction through the mechanisms that decrease the effect of oxidative stress, inflammation, apoptosis and necrosis.

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“…Brain temperature can be lowered by intra-arterial local infusion of cold fluid into the ischemic zone via an intraluminal filament Luan et al, 2004;Zhao et al, 2009). Intra-arterial cold infusions (IACI) have long been used during surgical procedures to prevent ischemic brain injury (Matsuwaka et al, 1998).…”

Section: Intra-arterial Local Coolingmentioning

confidence: 99%

Therapeutic hypothermia for stroke: Where to go?

Han

Liu

Luo

et al. 2015

Experimental Neurology

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Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats

Cited by 27 publications

References 18 publications

Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion

Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion

Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model

Therapeutic hypothermia for stroke: Where to go?

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