Mechanical structural systems are subject to multiple dynamic disturbances during service. While several possible scenarios can be examined to determine their design loading conditions, only a relatively small set of such scenarios is considered critical. Therefore, only such particular deterministic set of critical load cases is commonly employed for the structural design and optimization. Nevertheless, during the design and optimization stages, the mass and stiffness distributions of such assemblies vary, and, in consequence, their dynamic response also varies. Thus, it is important to consider the variations in the dynamic loading conditions during the design-and-optimization cycles. This paper studies the modal participation factors at length and proposes an alternative to the current point-wise treatment of the dynamic equations of motion of flexible bodies during design optimization. First, the most relevant-to-structural-dynamics definitions available in the literature are reviewed in depth. Second, the analysis of those definitions that have the potential to be adopted as point-wise constraint equations during structural optimization is extended. Finally, a proof of concept is presented to demonstrate the usability of each definition, followed by a case study in which the potential advantages of the proposed extended analysis are shown.