Local oxidative stress in interdigital tinea pedis

Öztürk, Perihan; Arıcan, Özer; Kurutaş, Ergül Belge; Karakas, Tugba; Güngör, Meltem

doi:10.1111/1346-8138.12043

Cited by 12 publications

(10 citation statements)

References 17 publications

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“…However, there is one study in humans. Ozturk et al reported that lipid peroxidation levels in scraping sample of TP patients increased more than control group as similar to our study [ 20 ]. This may be an indication of oxidative stress derived from inflammation in this lesional area.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

et al. 2016

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BackgroundTinea pedis (TP) is an infection of the feet caused by fungi. The infectious diseases caused by dermatophytes are mainly related to the enzymes produced by these fungi. Up to the now, the local 8-iso-prostaglandin F2α (8-iso-PGF2α), concentration as oxidative stress biomarker and trace elements status have not been published in patients with TP. The aim of this study is to evaluate the relationship between oxidative stress and trace elements (Cu, Zn, Se), and to evaluate the ratios of Cu/Zn and Cu/Se in this disorder.MethodsForty-three consecutive patients with a diagnosis of unilateral interdigital TP were enrolled in this study. The samples were obtained by scraping the skin surface. 8-iso-PGF2α concentrations in scraping samples were determined by ELISA. In addition, the levels of Se, Zn and Cu in scraping samples were determined on flame and furnace atomic absorption spectrophotometer using Zeeman background correction.ResultsOxidative stress was confirmed by the significant elevation in 8-iso-PGF2α concentrations (p < 0.05). When compared to non-lesional area, Zn and Se levels were significantly lower on lesional area, whereas Cu levels was higher on the lesional area than the non-lesional area (p < 0.05). In addition, the correlation results of this study were firstly shown that there were significant and positive correlations between Cu and 8-iso-PGF2α parameters, but negative correlations between Se-Cu; Se-8-iso-PGF2α parameters in lesional area. Furthermore, the ratios of Cu/Zn and Cu/Se were significantly higher on the lesional area than the non-lesional area (p < 0.05). According to sex and fungal subtypes, there was no significant difference in the concentrations of 8-iso-PGF2α and trace elements in patients with TP (p > 0.05).ConclusionsOur results showed that there is a possible link between oxidative stress (increased 8-iso-PGF2α concentrations) and imbalanced of trace elements status in lesional area of TP patients. The use of antifungal agents together with both Zn and Se drugs could be helpful in the both regression of disease and in shortening the duration of disease.

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Section: Discussionsupporting

confidence: 92%

Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis

et al. 2016

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“…Moreover, Malassezia spp may lead to skin diseases such as seborrhoeic dermatitis, atophic dermatitis and psoriasis in addition to PV. Thus, in our previous study which investigated local oxidative stress in tinea pedis and seborrhoeic dermatitis, we found increased SOD and MDA levels in patients . Also, Emre et al .…”

Section: Discussionmentioning

confidence: 56%

The evaluation of local oxidative/nitrosative stress in patients with pityriasis versicolor: a preliminary study

Kurutaş

Öztürk

2016

Mycoses

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Yeast of Malassezia, members of the microbiologic flora of the skin, cause pityriasis versicolor and have also been implicated in the pathogenesis of other superficial dermatoses. The mechanisms by which the yeast cause these dermatoses, however, are not yet clear, and there have been no studies on the interaction between fungi and keratinocytes, especially the effects of fungi on the production of reactive oxygen/nitrogen species by human keratinocytes. This is the first study we aimed to evaluate the role of oxidative/nitrosative stress in affected skin areas in patients with pityriasis versicolor. Sixty pityriasis versicolor patients and 60 healthy subjects as control group were enrolled. Scraping samples were obtained from the lesional skin areas in patients and from the normal skin areas in controls. The distribution of lesions of pityriasis versicolor was mild in all patients. We have isolated two Malassezia species: M. furfur being isolated in 75% of patients, followed by M. globosa (25%). The levels of oxidative/nitrosative stress biomarkers were significantly higher in patients than the controls (P < 0.001). Our results demonstrated that pityriasis versicolor is associated with significant alteration in oxidant/antioxidant balance. It might be secondary consequence of pityriasis versicolor infection or contributing factor in its pathogenesis.

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“…Ozturk et al reported that antioxidant defense of lesional skin was higher compared to non-lesional skin in patients with interdigital types of tinea pedis. 21 Miraloglu et al also reported that there was a possible link between oxidative stress and imbalance of trace element status in lesional areas of tinea pedis patients. 22 When these studies are considered, it is thought that there might be a relationship between tinea pedis and oxidative stress ; however, there is not yet enough data to prove this interrelation.…”

Section: Accepted Manuscriptmentioning

confidence: 96%