Local Stiffness of the Carotid and Femoral Artery Is Associated With Incident Cardiovascular Events and All-Cause Mortality

Sloten, Thomas T. van; Schram, Miranda T.; Hurk, Katja van den; Dekker, Joost; Nijpels, Giel; Henry, Ronald M.A.; Stehouwer, Coen D. A.

doi:10.1016/j.jacc.2013.12.041

Cited by 260 publications

(211 citation statements)

References 28 publications

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“…Arterial stiffness is not uniform along the arterial tree; therefore, assessment of arterial stiffness at different sites in relation to clinical outcomes is important (29). We have previously shown that arterial stiffness measured as carotid femoral PWV is associated with cardiovascular morbidity and mortality; however, we did not observe such an association with stiffness in the carotid artery.…”

Section: Discussioncontrasting

confidence: 69%

Arterial Stiffness and Decline in Kidney Function

Sedaghat¹,

Mattace-Raso²,

Hoorn³

et al. 2015

Clinical Journal of the American Society of Nephrology

135

112

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Background and objectives The independent link between arterial stiffness and CKD remains unknown. We investigated the association of indicators of arterial stiffness with decline in kidney function.Design, setting, participants, & measurements We studied 3666 participants (mean age =65 years old; 58% women) from the Rotterdam Study. Pulse pressure (PP), carotid stiffness, and pulse wave velocity (PWV) were measured. We created genetic risk scores for PP and PWV. Annual declines in kidney function and incident CKD were assessed using eGFR. To put our findings in context of the literature, we performed a meta-analysis of the available population-based studies.Results After a median (interquartile range) follow-up time of 11 (10.7-11.3) years, 601 participants with incident CKD were recognized. In the model adjusted for age, sex, mean arterial pressure, heart rate, and baseline GFR, each SD higher PP was associated with 0.15-ml/min per 1.73 m 2 steeper annual eGFR decline (95% confidence interval [95% CI], 0.10 to 0.20) and 11% higher risk of incident CKD (95% CI, 1.05 to 1.18). Each SD greater carotid stiffness was associated with 0.08-ml/min per 1.73 m 2 steeper annual eGFR decline (95% CI, 0.04 to 0.13) and 13% higher risk of incident CKD (95% CI, 1.05 to 1.22). Each SD higher PWV was associated with 7% higher risk of incident CKD (95% CI, 1.00 to 1.14). Incorporating our findings in a meta-analysis, each SD higher PP and PWV were associated with 16% (95% CI, 1.12 to 1.21) and 8% (95% CI, 1.03 to 1.14) higher risks of incident CKD. Each SD higher PP genetic risk score was associated with 0.06-ml/min per 1.73 m 2 steeper annual eGFR decline (95% CI, 0.01 to 0.10) and 8% higher risk of incident CKD (95% CI, 1.03 to 1.14). There was no association between PWV genetic risk score and kidney function decline.Conclusions Higher indices of arterial stiffness are associated with steeper decline in kidney function. This suggests that vascular stiffness could be considered as a target for delaying decline in kidney function.

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Section: Discussioncontrasting

confidence: 69%

Arterial Stiffness and Decline in Kidney Function

Sedaghat¹,

Mattace-Raso²,

Hoorn³

et al. 2015

Clinical Journal of the American Society of Nephrology

135

112

View full text Add to dashboard Cite

show abstract

“…For this reason, there has been large interest in methods for the assessment of arterial stiffness, a potentially potent biomarker of cardiovascular disease with demonstrated prognostic ability [3][4][5][6]. In the clinical setting, arterial stiffness is most commonly derived by measuring the pulse wave velocity (i.e., the speed with which the arterial pulse travels along the arterial segment) [7,8].…”

Section: Introductionmentioning

confidence: 99%

Supersonic Shear Wave Imaging to Assess Arterial Nonlinear Behavior and Anisotropy: Proof of Principle via Ex Vivo Testing of the Horse Aorta

Shcherbakova

Papadacci

Swillens

et al. 2014

Advances in Mechanical Engineering

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Supersonic shear wave imaging (SSI) is a noninvasive, ultrasound-based technique to quantify the mechanical properties of bulk tissues by measuring the propagation speed of shear waves (SW) induced in the tissue with an ultrasound transducer. The technique has been successfully validated in liver and breast (tumor) diagnostics and is potentially useful for the assessment of the stiffness of arteries. However, SW propagation in arteries is subjected to different wave phenomena potentially affecting the measurement accuracy. Therefore, we assessed SSI in a less complex ex vivo setup, that is, a thick-walled and rectangular slab of an excised equine aorta. Dynamic uniaxial mechanical testing was performed during the SSI measurements, to dispose of a reference material assessment. An ultrasound probe was fixed in an angle position controller with respect to the tissue to investigate the effect of arterial anisotropy on SSI results. Results indicated that SSI was able to pick up stretch-induced stiffening of the aorta. SW velocities were significantly higher along the specimen's circumferential direction than in the axial direction, consistent with the circumferential orientation of collagen fibers. Hence, we established a first step in studying SW propagation in anisotropic tissues to gain more insight into the feasibility of SSI-based measurements in arteries.

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“…19 It was also hypothesized that modification of arterial stiffness may influence future CV events. Studies performed so far have reported conflicting results on the effect of antihypertensive treatment on arterial stiffness.…”

Section: -17mentioning

confidence: 99%

Arterial structure and function in subjects with acute coronary syndrome after one-year of treatment

Schneider¹,

Gawęcka²,

Mińczykowski³

et al. 2017

Polish Archives of Internal Medicine

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Local Stiffness of the Carotid and Femoral Artery Is Associated With Incident Cardiovascular Events and All-Cause Mortality

Abstract: Carotid and femoral stiffness indices are independently associated with incident cardiovascular events and all-cause mortality. The strength of these associations with events may differ per stiffness parameter.

Cited by 260 publications

References 28 publications

Arterial Stiffness and Decline in Kidney Function

Arterial Stiffness and Decline in Kidney Function

Supersonic Shear Wave Imaging to Assess Arterial Nonlinear Behavior and Anisotropy: Proof of Principle via Ex Vivo Testing of the Horse Aorta

Arterial structure and function in subjects with acute coronary syndrome after one-year of treatment

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