Local tissue effects of copper-containing intrauterine devices

Patai, K; Szilágyi, György; Noszál, Béla; Szentmariay, I. F

doi:10.1016/s0015-0282(03)01171-3

Cited by 22 publications

(12 citation statements)

References 4 publications

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“…As Mycoplasmas are conditional pathogens, they are found to be associated with various diseases, including pneumonia, arthritis, meningitis and chronic urogenital tract disease [14,15]. Mycoplasmas are also found to be associated with various pathological conditions and intrauterine infections, including pyelonephritis, pelvic inflammatory disease, chorioamnionitis, endometritis, and postpartum fever, leading to important complications such as preterm birth, low birth weight, spontaneous abortion, stillbirth, premature birth, infertility, and perinatal mortality [16][17][18][19][20][21][22]. Mycoplasmas have also been found to be associated with bacterial vaginosis [23].…”

Section: Introductionmentioning

confidence: 99%

Genome Wide Analysis of Intergenic Regions in Mycoplasma Genomes for Functional Characterization: An in Silico Approach

Angamuthu¹,

Ramalingam²

2018

International Journal of Microbiology Research

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IntroductionBacterial intergenic regions have become one of the major thrust areas of research as the functional elements concealed in these regions still remain unraveled. Bacterial intergenic regions encompass various control elements and signals for the regulation of transcription [1]. Microbial intergenic regions have also been found to harbor functional elements like transposons [2]. Genome-wide analysis of the intergenic regions through computational and experimental methods in the genome of Mesorhizobium huakuii 7653R has resulted in the identification of putative novel small non-coding RNAs [3]. Intergenic regions have largely been thought to contain small non-coding RNAs [4]. However, studies suggest that intergenic regions may possess functional small-length coding regions that are not normally annotated in gene prediction programs [5][6][7]. A high degree of sequence conservation and genetic diversity have been discovered from the analysis of intergenic regions of Trypanosoma cruzi genome [8]. As intergenic spacer regions are highly conserved, these sequences are used as potential tools for strain typing of Mycoplasma synoviae species [9]. In general, intergenic regions of prokaryotes are relatively shorter than that of eukaryotes. In contrast to eukaryotes, evolutionary pressure has minimized the amount of nonfunctional DNA in prokaryotic genomes. Most of the bacterial and archeal genomes were found to have 6-14 % of non-coding DNA [10]. Prokaryotes make use of the operon system to reduce the number of regulatory elements that control transcription of genes [11]. Mycoplasmas are the smallest and simplest known free-living and self-replicating organisms with smallest genomes (0.58-2.20Mb). During the course of their reductive evolution from Gram-positive bacteria, Mycoplasmas have lost several genes involved in metabolism, cellular process and energy production, transcription regulation, cell division and heat shock response [12].

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Section: Introductionmentioning

confidence: 99%

Genome Wide Analysis of Intergenic Regions in Mycoplasma Genomes for Functional Characterization: An in Silico Approach

Angamuthu¹,

Ramalingam²

2018

International Journal of Microbiology Research

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“…It is suggested that the cellular and biochemical changes occur in the endometrium after Cu-IUD insertion. [40][41][42] Findings from several in vitro and in vivo assays provide evidence that copper ions are capable of interacting directly with macromolecules, modifying conformational structures and thus causing sitespecific damage, [43][44][45] and indirectly catalyzing through the Fenton/Haber-Weiss reaction the formation of reactive oxygen species and causing several cellular alterations. [46][47][48] In addition, ions from metals such as copper exhibit a high affinity for thiol groups and may therefore severely disturb many cell metabolic functions.…”

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confidence: 99%

“…The prophase of study confirms that the material releases copper ions in a steady velocity in a simulated uterine solution, which differs from the burst release of copper ions of conventional Cu-IUDs. 18,40,41,52 The size effect of copper nanoparticles can control copper ion release velocity. 53 With the same copper content, the nano-Cu/LDPE IUD releases more copper ions than the conventional Cu-IUD in the same liquid environment.…”

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confidence: 99%

“…40 The surface of the bulk copper of the existing Cu-IUDs becomes coarser and coarser with increasing time in the uterine solution, because of the corrosion of copper. 54 Finally, the corrosion products, such as Cu 2 O, Cu(OH) 2 , and CaCO 3 , are deposited on the surface of the bulk copper; such hard, calcified deposits as CaCO 3 will aggravate the damage of the endometrium.…”

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confidence: 99%

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Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Hu¹,

Wang²,

Rao³

et al. 2014

IJN

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A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. A logical extension of our previous work, this study was conducted to investigate the expression of plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and substance P receptor (SP-R) in the endometrium of Sprague Dawley rats, New Zealand White rabbits, and Macaca mulatta implanted with nano-Cu/LDPE composite. The influence of the nano-Cu/LDPE composite on the morphology of the endometrium was also investigated. Animals were randomly divided into five groups: the sham-operated control group (SO group), bulk copper group (Cu group), LDPE group, and nano-Cu/LDPE groups I and II. An expression of PAI-1, SP, and SP-R in the endometrial tissues was examined by immunohistochemistry at day 30, 60, 90, and 180 postimplantation. The significant difference for PAI-1, SP, and SP-R between the nano-Cu/LDPE groups and the SO group ( P <0.05) was identified when the observation period was terminated, and the changes of nano-Cu/LDPE on these parameters were less remarkable than those of the Cu group ( P <0.05). The damage to the endometrial morphology caused by the nano-Cu/LDPE composite was much less than that caused by bulk copper. The nano-Cu/LDPE composite might be a potential substitute for conventional materials for intrauterine devices in the future because of its decreased adverse effects on the endometrial microenvironment.

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“…Finally, the corrosion products, such as Cu(OH) 2 and CaCO 3 are deposited on the surface of the bulk copper (16,17); such hard calcified deposit as CaCO will aggravate the damage of endometrium. It has already been found that the damage of the endometrium is related to the surface condition of the Cu-IUDs (18). To eliminate or lessen the side effects of the existing Cu-IUDs, these disadvantages of the existing Cu-IUDs should be avoided.…”

mentioning

confidence: 99%

Effect of implanted Cu/low-density polyethylene nanocomposite on the morphology of endometrium in the mouse

Xia¹,

Xie²,

Zhu³

et al. 2007

Fertility and Sterility

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Local tissue effects of copper-containing intrauterine devices

Cited by 22 publications

References 4 publications

Genome Wide Analysis of Intergenic Regions in Mycoplasma Genomes for Functional Characterization: An in Silico Approach

Genome Wide Analysis of Intergenic Regions in Mycoplasma Genomes for Functional Characterization: An in Silico Approach

Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite

Effect of implanted Cu/low-density polyethylene nanocomposite on the morphology of endometrium in the mouse

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