Local wound management: A review of modern techniques and products

Aisa, Josep; Parlier, Mark

doi:10.1111/vde.13104

Cited by 9 publications

(5 citation statements)

References 124 publications

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“…Diabetes, immunosuppression, corticosteroids and smoking may complicate wound healing [7]. Patients with diabetes, in particular, often exhibit abnormalities in cells characterized by low proliferation potential and an impaired ability to respond to environmental signals [8]. A characteristic feature of every wound, regardless of its origin, is chronic inflammation of the wound bed and lack of healing [9].…”

Section: Introductionmentioning

confidence: 99%

“…[23] Growth factors and other Maspin Anti-angiogenic factor secreted by keratinocytes. [24] Chronic wounds can be treated through standard methods such as dressings, negative pressure therapy or transplantation [8,11,25]. Transplantation of skin on healthy MHC-mismatched recipients leads to rapid immune rejection within 10-14 days with characteristic skin tissue destruction.…”

Section: Introductionmentioning

confidence: 99%

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Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Kondej,

Zawrzykraj,

Czerwiec

et al. 2024

IJMS

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Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Kondej,

Zawrzykraj,

Czerwiec

et al. 2024

IJMS

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show abstract

“…The most used included interactive dressings, which include films, foams, hydrogels, hydrocolloids, and alginates. Apart from these, there are other new inventions such as bioactive dressings like cellular mediators and growth factors, as well as some tissue engineering dressings like biosynthetic fish skin grafts [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced wound healing potential of arabincoside B isolated from Caralluma Arabica in rat model; a possible dressing in veterinary practice

Ali,

Al-Mokaddem,

Abdel-Sattar

et al. 2024

BMC Vet Res

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Background Wound management is a critical procedure in veterinary practice. A wound is an injury that requires the body’s cells’ alignment to break down due to external assault, such as trauma, burns, accidents, and diseases. Re-epithelization, extracellular matrix deposition, especially collagen, inflammatory cell infiltration, and development of new blood capillaries are the four features that are used to evaluate the healing process. Using a natural extract for wound management is preferred to avoid the side effects of synthetic drugs. The current study aimed to assess the effect of major pregnane glycoside arabincoside B (AR-B) isolated from Caralluma arabica (C. arabica) for the wound healing process. Method AR-B was loaded on a gel for wound application. Rats were randomly distributed into six groups: normal, positive control (PC), MEBO®, AR-B 0.5%, AR-B 1%, and AR-B 1.5%, to be 6 animals in each group. Wounds were initiated under anesthesia with a 1 cm diameter tissue needle, and treatments were applied daily for 14 days. The collected samples were tested for SOD, NO, and MDA. Gene expression of VEGF and Caspase-3. Histopathological evaluation was performed at two-time intervals (7 and 14 days), and immunohistochemistry was done to evaluate α -SMA, TGF-β, and TNF-α. Result It was found that AR-B treatment enhanced the wound healing process. AR-B treated groups showed reduced MDA and NO in tissue, and SOD activity was increased. Re-epithelization and extracellular matrix deposition were significantly improved, which was confirmed by the increase in TGF-β and α -SMA as well as increased collagen deposition. TNF-α was reduced, which indicated the subsiding of inflammation. VEGF and Caspase-3 expression were reduced. Conclusion Our findings confirmed the efficiency of AR-B in enhancing the process of wound healing and its potential use as a topical wound dressing in veterinary practice.

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“…The primary goal of wound management is to facilitate the swiftest possible healing of the wound while minimizing patient discomfort and scarring [ 19 ]. Effective wound treatment should aim to minimize scar tissue formation, reduce necrotic tissue production, and thwart the infiltration of microbes.…”

Section: Introductionmentioning

confidence: 99%

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

Prete,

Dattilo,

Patitucci

et al. 2023

JFB

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Biomaterials are at the forefront of the future, finding a variety of applications in the biomedical field, especially in wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try to heal through a series of interconnected processes involving several initiators and mediators such as cytokines, macrophages, and fibroblasts. The combination of biopolymers with wound healing properties may provide opportunities to synthesize matrices that stimulate and trigger target cell responses crucial to the healing process. This review outlines the optimal management and care required for wound treatment with a special focus on biopolymers, drug-delivery systems, and nanotechnologies used for enhanced wound healing applications. Researchers have utilized a range of techniques to produce wound dressings, leading to products with different characteristics. Each method comes with its unique strengths and limitations, which are important to consider. The future trajectory in wound dressing advancement should prioritize economical and eco-friendly methodologies, along with improving the efficacy of constituent materials. The aim of this work is to give researchers the possibility to evaluate the proper materials for wound dressing preparation and to better understand the optimal synthesis conditions as well as the most effective bioactive molecules to load.

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Local wound management: A review of modern techniques and products

Cited by 9 publications

References 124 publications

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Enhanced wound healing potential of arabincoside B isolated from Caralluma Arabica in rat model; a possible dressing in veterinary practice

Natural and Synthetic Polymeric Biomaterials for Application in Wound Management

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