Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs

Mg, Olavesen; Snoek, Michiel; Campbell, R. Duncan

doi:10.1007/bf00216806

Cited by 13 publications

(3 citation statements)

References 18 publications

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“…Whether G7b or GTa are polymorphic between B10.A(1R) and B10.A(2R) is not known yet. The interval between G7b and G7a may harbor additional genes (Snoek et al 1994b;Olavesen et al 1993).…”

Section: Lung Tumor Size and Lung Tumor Loadmentioning

confidence: 99%

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex

et al. 1995

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Lung tumor susceptibility (LTS) in the mouse is influenced by multiple loci within the H2 complex. We compared the LTS of two H2 congenic strains with intra H2 recombinations, B10.A(1R) and B10.A(2R), whose genetic difference has been reduced to a region of approximately 50 kilobases within the C4-H2D interval, between Hsp70.3 and G7. After transplacental induction with N-ethyl-N-nitrosourea the load of alveolar lung tumors in strain B10.A(2R) is significantly higher than in strain B10.A(1R) (P < 0.001). For papillary tumors no significant differences were observed. We conclude that the alveolar lung tumor load is influenced by an LTS gene located within the Hsp70.3-G7 interval.

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“…Whether G7b or GTa are polymorphic between B10.A(1R) and B10.A(2R) is not known yet. The interval between G7b and G7a may harbor additional genes (Snoek et al 1994b;Olavesen et al 1993).…”

Section: Lung Tumor Size and Lung Tumor Loadmentioning

confidence: 99%

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex

et al. 1995

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“…With the recent identification of a previously unrecognized gene adjacent to the Hsp70 genes in both humans and the mouse (Olavensen et al 1993), conserved organization of 16 loci in the interval between C2 and the most centromeric class I locus has been proved. The P1 cloning system dramatically facilitated our cloning effort.…”

Section: This Study Demonstrates That the Genes In Thementioning

confidence: 99%

“…This region is of particular interest because the genes controlling several phenotypic traits appear to map within it. A gene that affects the antibody response to TNP-Ficoll (Shapiro et al 1985), the locus that controls the hematopoietic histocompatibility antigen, Hh-1 (Daley et al 1987), a gene that affects susceptibility to cortisone-induced cleft palate, Cps-1 (Gasser et al 1988), and a gene that affects susceptibility to experimental autoimmune orchitis, Orch-1 (Teuscher et al 1990;Snoek et al 1993), have all been localized to this interval. The isolation of this portion of the mouse H-2 complex in molecular clones will facilitate the identification of these functionally defined genes.…”

Section: Introductionmentioning

confidence: 99%

P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci

et al. 1994

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A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes that are homologous to genes initially mapped within the human major histocompatibility complex. These include the mouse homologs of BAT2 (HLA-B-associated transcript 2) through BAT9 and also three HSP70-related genes. Five P1 clones form a contig of 240 kb that spans from BAT9 through BAT3. Twelve cosmid clones are arranged in three contigs that confirm most of the structure of the P1 contig and link the mouse BAT3 homolog to the BAT2 homolog approximately 15 kb farther telomeric. Polymorphic DNA markers within the cloned region were used to map the cleft palate susceptibility-1 (Cps-1) locus to the interval between Hsp70.1 and BAT6 (valyl-tRNA synthetase). This refines the location of the Cps-1 locus to a 45 kb region contained in the H2-124 P1 insert.

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Coding sequences and levels of expression of Hsc70t are identical in mice with different Orch-1 alleles

et al. 1994

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Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs

Cited by 13 publications

References 18 publications

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex

A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex

P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci

Coding sequences and levels of expression of Hsc70t are identical in mice with different Orch-1 alleles

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