Coding sequences and levels of expression of Hsc70t are identical in mice with different Orch-1 alleles

Snoek, Michiel; Olavesen, Mark G.; Vugt, H. van; Milner, Caroline M.; Teuscher, Cory; Campbell, R. Duncan

doi:10.1007/bf00188181

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Hsc70t encodes a heat shock protein that is constitutively expressed in the testis. It is not polymorphic between B10.A(1R) and B10.A[(2R) (Snoek et al 1994b)1, and is therefore not a likely candidate for the LTS gene. The function of G7b is unknown , while G7a codes for a valyl-tRNA synthetase (Hsieh and Campbell 1991).…”

Section: Lung Tumor Size and Lung Tumor Loadmentioning

confidence: 99%

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A susceptibility gene for alveolar lung tumors in the mouse maps between Hsp70.3 and G7 within the H2 complex

et al. 1995

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Lung tumor susceptibility (LTS) in the mouse is influenced by multiple loci within the H2 complex. We compared the LTS of two H2 congenic strains with intra H2 recombinations, B10.A(1R) and B10.A(2R), whose genetic difference has been reduced to a region of approximately 50 kilobases within the C4-H2D interval, between Hsp70.3 and G7. After transplacental induction with N-ethyl-N-nitrosourea the load of alveolar lung tumors in strain B10.A(2R) is significantly higher than in strain B10.A(1R) (P < 0.001). For papillary tumors no significant differences were observed. We conclude that the alveolar lung tumor load is influenced by an LTS gene located within the Hsp70.3-G7 interval.

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Section: Lung Tumor Size and Lung Tumor Loadmentioning

confidence: 99%

“…Whether G7b or GTa are polymorphic between B10.A(1R) and B10.A(2R) is not known yet. The interval between G7b and G7a may harbor additional genes (Snoek et al 1994b;Olavesen et al 1993).…”

Section: Lung Tumor Size and Lung Tumor Loadmentioning

confidence: 99%